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Protein Ontology report - estrogen receptor isoform 1

PR:000027721 - http://purl.obolibrary.org/obo/PR_000027721

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000027721

PRO name

estrogen receptor isoform 1

Synonyms

PRO-Short-label:

EXACT:

ESR1/iso:1

Definition

"An estrogen receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-1 or a 1:1 ortholog thereof." [PMID:19940156, PRO:CNA]

PRO Category

sequence

Parent

PR:000007204 estrogen receptor

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	1
Modification	6	Organism-Modification	6

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000027721 estrogen receptor isoform 1

ESR1/iso:1

organism-sequence

PR:P03372-1 estrogen receptor isoform 1 (human)

hESR1/iso:1

organism-modification

PR:000027724 estrogen receptor isoform 1 phosphorylated 1 (human)

hESR1/iso:1/Phos:1

Yes

organism-modification

PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human)

hESR1/iso:1/Phos:2

Yes

organism-modification

PR:000027754 estrogen receptor isoform 1 phosphorylated 3 (human)

hESR1/iso:1/Phos:3

organism-modification

PR:000027756 estrogen receptor isoform 1 acetylated 1 (human)

hESR1/iso:1/Ac:1

Yes

organism-modification

PR:000027776 estrogen receptor isoform 1 phosphorylated 4 (human)

hESR1/iso:1/Phos:4

Yes

organism-modification

PR:000027778 estrogen receptor isoform 1 phosphorylated 5 (human)

hESR1/iso:1/Phos:5

modification

PR:000027723 estrogen receptor isoform 1 phosphorylated 1

ESR1/iso:1/Phos:1

organism-modification

PR:000027724 estrogen receptor isoform 1 phosphorylated 1 (human)

hESR1/iso:1/Phos:1

Yes

modification

PR:000027725 estrogen receptor isoform 1 phosphorylated 2

ESR1/iso:1/Phos:2

organism-modification

PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human)

hESR1/iso:1/Phos:2

Yes

modification

PR:000027753 estrogen receptor isoform 1 phosphorylated 3

ESR1/iso:1/Phos:3

organism-modification

PR:000027754 estrogen receptor isoform 1 phosphorylated 3 (human)

hESR1/iso:1/Phos:3

modification

PR:000027755 estrogen receptor isoform 1 acetylated 1

ESR1/iso:1/Ac:1

organism-modification

PR:000027756 estrogen receptor isoform 1 acetylated 1 (human)

hESR1/iso:1/Ac:1

Yes

modification

PR:000027775 estrogen receptor isoform 1 phosphorylated 4

ESR1/iso:1/Phos:4

organism-modification

PR:000027776 estrogen receptor isoform 1 phosphorylated 4 (human)

hESR1/iso:1/Phos:4

Yes

modification

PR:000027777 estrogen receptor isoform 1 phosphorylated 5

ESR1/iso:1/Phos:5

organism-modification

PR:000027778 estrogen receptor isoform 1 phosphorylated 5 (human)

hESR1/iso:1/Phos:5

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000027724 hESR1/iso:1/Phos:1 UniProtKB:P03372-1, Ser-167, MOD:00046	acts_upstream_of_or_within	GO:0045893 positive regulation of DNA-templated transcription	PMID:19940156
PR:000027726 hESR1/iso:1/Phos:2 UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048	acts_upstream_of_or_within	GO:0010628 positive regulation of gene expression	PMID:20101225
	enables	GO:0042803 protein homodimerization activity	PMID:20101225
	located_in	GO:0005634 nucleus	PMID:20101225
PR:000027756 hESR1/iso:1/Ac:1 UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064	enables	GO:0003677 DNA binding	PMID:16497729
PR:000027776 hESR1/iso:1/Phos:4 UniProtKB:P03372-1, Thr-311, MOD:00047	acts_upstream_of_or_within	GO:0010628 positive regulation of gene expression	PMID:12138194
	located_in	GO:0005634 nucleus	PMID:12138194