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Protein Ontology report - RING-box protein 1 related protein
PR:000027961 - http://purl.obolibrary.org/obo/PR_000027961
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000027961   
  PRO nameRING-box protein 1 related protein 
  Synonyms
PRO-Short-label: EXACT:fam:RBX1
Other: RELATED:regulator of cullins 1
  Definition"A RING-box protein that is a translation product of the human RBX1 gene, the Arabidopsis thaliana RBX1A or RBX1B genes, or 1:1 orthologs thereof. It contains a copy of the RING-H2 zinc finger (Pfam:PF12678) domain." [PRO:PD] 
  PRO Categoryfamily 
  ParentPR:000000004 RING-box protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 1                                        
         Gene1                                                  Organism-Gene 9                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500724
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000027961

RING-box protein 1 related protein

fam:RBX1


"A RING-box protein that is a translation product of the human RBX1 gene, the Arabidopsis thaliana RBX1A or RBX1B genes, or 1:1 orthologs thereof. It contains a copy of the RING-H2 zinc finger (Pfam:PF12678) domain." [PRO:PD]


gene



PR:000000043

E3 ubiquitin-protein ligase RBX1

RBX1


"A RING-box protein 1 related protein that is a translation product of the human RBX1 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:O13959

RING-box protein pip1 (Schizosaccharomyces pombe 972h-)

Spom972h-RBX1


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O13959, PRO:DNx]


organism-gene



PR:P62877

E3 ubiquitin-protein ligase RBX1 (human)

hRBX1


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P62877]


organism-sequence



PR:P62877-1

E3 ubiquitin-protein ligase RBX1 isoform 1 (human)

hRBX1/iso:1


"An E3 ubiquitin-protein ligase RBX1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026756

E3 ubiquitin-protein ligase RBX1, initiator methionine removed form (human)

hRBX1/InitMet-


"An E3 ubiquitin-protein ligase RBX1, initiator methionine removed form in human. UniProtKB:P62877, 2-108." [PRO:DNx]


Yes
organism-modification



PR:000065210

E3 ubiquitin-protein ligase RBX1 methylated 1 (human)

hRBX1/Me:1


"An E3 ubiquitin-protein ligase RBX1 (human) that has been methylated on the residue at the position equivalent to Cys-83 of the amino acid sequence represented by UniProtKB:P62877. UniProtKB:P62877, Cys-83, MOD:00660." [IEDB_epitope:1017283, IEDB_epitope:1035364, PRO:DNx]


organism-modification



PR:000065917

E3 ubiquitin-protein ligase RBX1 cysteinylated 1 (human)

hRBX1/Cyst:1


"An E3 ubiquitin-protein ligase RBX1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-75 of the amino acid sequence represented by UniProtKB:P62877. UniProtKB:P62877, Cys-75, MOD:00765." [IEDB_epitope:926381, PRO:DNx]


organism-modification



PR:000068175

E3 ubiquitin-protein ligase RBX1 cysteinylated 2 (human)

hRBX1/Cyst:2


"An E3 ubiquitin-protein ligase RBX1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-83 of the amino acid sequence represented by UniProtKB:P62877. UniProtKB:P62877, Cys-83, MOD:00765." [IEDB_epitope:1011802, IEDB_epitope:881271, PRO:DNx]


organism-gene



PR:P62878

E3 ubiquitin-protein ligase RBX1 (mouse)

mRBX1


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of mouse." [OMA:P62878, PRO:DNx]


organism-sequence



PR:P62878-1

E3 ubiquitin-protein ligase RBX1 isoform 1 (mouse)

mRBX1/iso:1


"An E3 ubiquitin-protein ligase RBX1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q08273

RING-box protein HRT1 (yeast)

yRBX1


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of yeast." [OMA:Q08273, PRO:DNx]


organism-gene



PR:Q23457

RING-box protein 1 (worm)

RBX1 (worm)


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of worm." [OMA:Q23457, PRO:DNx]


organism-gene



PR:Q54K33

RING-box protein 1 (Dictyostelium discoideum)

Dicty-RBX1


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54K33, PRO:DNx]


organism-gene



PR:Q9W5E1

RING-box protein 1A (fruit fly)

fly-RBX1


"An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of fruit fly." [OMA:Q9W5E1, PRO:DNx]


sequence



PR:000000177

E3 ubiquitin-protein ligase RBX1 isoform 1

RBX1/iso:1


"An E3 ubiquitin-protein ligase RBX1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62877-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P62877-1

E3 ubiquitin-protein ligase RBX1 isoform 1 (human)

hRBX1/iso:1


"An E3 ubiquitin-protein ligase RBX1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:P62878-1

E3 ubiquitin-protein ligase RBX1 isoform 1 (mouse)

mRBX1/iso:1


"An E3 ubiquitin-protein ligase RBX1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026660

E3 ubiquitin-protein ligase RBX1 isoform 1, initiator methionine removed form

RBX1/iso:1/InitMet-


"An E3 ubiquitin-protein ligase RBX1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018272

E3 ubiquitin-protein ligase RBX1, initiator methionine removed form

RBX1/InitMet-


"An E3 ubiquitin-protein ligase RBX1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026660

E3 ubiquitin-protein ligase RBX1 isoform 1, initiator methionine removed form

RBX1/iso:1/InitMet-


"An E3 ubiquitin-protein ligase RBX1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000026756

E3 ubiquitin-protein ligase RBX1, initiator methionine removed form (human)

hRBX1/InitMet-


"An E3 ubiquitin-protein ligase RBX1, initiator methionine removed form in human. UniProtKB:P62877, 2-108." [PRO:DNx]


Yes
organism-family



PR:000028456

RING-box protein 1 (Arabidopsis thaliana)

At-RBX1[a/b]


"A RING-box protein 1 related protein that is a translation product of any of the following genes in Arabidopsis thaliana: RBX1A/RBX1B." [PRO:DAN]


Yes




PR:Q940X7

RING-box protein 1a (Arabidopsis thaliana)











PR:Q9M2B0

RING-box protein 1b (Arabidopsis thaliana)







organism-gene



PR:Q940X7

RING-box protein 1a (Arabidopsis thaliana)

At-RBX1A


"A RING-box protein 1 related protein that is a translation product of the RBX1A gene in Arabidopsis thaliana." [PRO:CNA, PRO:DAN, UniProtKB:Q940X7]


organism-sequence



PR:Q940X7-1

RING-box protein 1a isoform 1 (Arabidopsis thaliana)

At-RBX1A/iso:1


"A RING-box protein 1a (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q940X7-1." [PRO:DNx, UniProtKB:Q940X7]


organism-gene



PR:Q9M2B0

RING-box protein 1b (Arabidopsis thaliana)

At-RBX1B


"A RING-box protein 1 related protein that is a translation product of the RBX1B gene in Arabidopsis thaliana." [PRO:CNA, PRO:DAN, UniProtKB:Q9M2B0]


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fam:RBX1 forms found in complexes   

fam:RBX1 Component
Complexes
PR:000026756 hRBX1/InitMet- PR:000026771 SCF beta-TrCP complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
PR:000028456 At-RBX1[a/b] PR:000028458 SCF(TIR1) complex (Arabidopsis thaliana)
PR:000028465 SCF(COI1) complex (Arabidopsis thaliana)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000043 RBX1 acts_upstream_of_or_withinGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PIRSF:PIRSF500724
located_inGO:0019005 SCF ubiquitin ligase complex PIRSF:PIRSF500724
PR:P62877-1 hRBX1/iso:1 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:10230407
GO:0006606 protein import into nucleus PMID:11027288
GO:0045116 protein neddylation PMID:15966899
enablesGO:0005515 protein binding with PR:Q13616-1 PMID:11027288
GO:0005515 protein binding with PR:Q9EQW6 mOLIG2 PMID:11027288
located_inGO:0000151 ubiquitin ligase complex PMID:17217622
GO:0000151 ubiquitin ligase complex PMID:17217622
GO:0019005 SCF ubiquitin ligase complex PMID:15966899
GO:0031462 Cul2-RING ubiquitin ligase complex PMID:15966899