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Protein Ontology report - endonuclease 8-like 2 isoform 1
PR:000028589 - http://purl.obolibrary.org/obo/PR_000028589
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000028589   
  PRO nameendonuclease 8-like 2 isoform 1 
  Synonyms
PRO-Short-label: EXACT:NEIL2/iso:1
  Definition"An endonuclease 8-like 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-1 or a 1:1 ortholog thereof." [PMID:15175427, PRO:PD] 
  PRO Categorysequence 
  ParentPR:000011123 endonuclease 8-like 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000028589
endonuclease 8-like 2 isoform 1
NEIL2/iso:1
"An endonuclease 8-like 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-1 or a 1:1 ortholog thereof." [PMID:15175427, PRO:PD]

organism-sequence


PR:Q969S2-1
endonuclease 8-like 2 isoform 1 (human)
hNEIL2/iso:1
"An endonuclease 8-like 2 isoform 1 that is encoded in the genome of human." [PRO:PD]

organism-modification


PR:000028592
endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)
hNEIL2/iso:1/InitMet-/Ac:1
"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]
Yes
organism-modification


PR:000045372
endonuclease 8-like 2 isoform 1 unacetylated 1 (human)
hNEIL2/iso:1/UnAc:1
"An endonuclease 8-like 2 isoform 1 (human) that lacks acetylation on Lys-50 and Lys-154. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291." [PMID:15175427, PRO:CNA]
Yes
modification


PR:000028590
endonuclease 8-like 2 isoform 1, initiator methionine removed form
NEIL2/iso:1/InitMet-
"An endonuclease 8-like 2 isoform 1 that has had the initiator methionine removed." [PMID:12097317, PRO:CNA]

modification


PR:000028591
endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1
NEIL2/iso:1/InitMet-/Ac:1
"An endonuclease 8-like 2 isoform 1, initiator methionine removed form that is acetylated. Example: UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

organism-modification


PR:000028592
endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)
hNEIL2/iso:1/InitMet-/Ac:1
"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000028592 hNEIL2/iso:1/InitMet-/Ac:1
UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064		 enablesdecreased GO:0019104 DNA N-glycosylase activity relative to PR:000045372 endonuclease 8-like 2 isoform 1 unmodified form (human) PMID:15175427
PR:000045372 hNEIL2/iso:1/UnAc:1
UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291		 enablesGO:0019104 DNA N-glycosylase activity PMID:15175427