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Protein Ontology report - AKT kinase
PR:000029189 - http://purl.obolibrary.org/obo/PR_000029189
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000029189   
  PRO nameAKT kinase 
  Synonyms
Other: EXACT:AKT | serine-threonine kinase Akt
  Definition"A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites." [PMID:9736715, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 12                                        
         Sequence3                                                  Organism-Sequence 18                                        
         Modification5                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000029189 AKT kinase
Firm-sspA/SigPep-

gene


PR:000002190 RAC-alpha serine/threonine-protein kinase
AKT1

organism-gene


PR:P31749 RAC-alpha serine/threonine-protein kinase (human)
hAKT1

organism-sequence


PR:000061890 RAC-alpha serine/threonine-protein kinase sequence variant E17K (human)
hAKT1/var:E17K

organism-sequence


PR:P31749-1 RAC-alpha serine/threonine-protein kinase isoform 1 (human)
hAKT1/iso:1

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hAKT1/iso:1/Phos:2
Yes
organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
hAKT1/iso:1/Phos:1
Yes
organism-sequence


PR:P31749-2 RAC-alpha serine/threonine-protein kinase isoform h2 (human)
hAKT1/iso:h2

organism-modification


PR:000046294 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human)
hAKT1/Phos:3

organism-modification


PR:000046295 RAC-alpha serine/threonine-protein kinase phosphorylated 4 (human)
hAKT1/Phos:4

organism-modification


PR:000046296 RAC-alpha serine/threonine-protein kinase phosphorylated 1 (human)
hAKT1/Phos:1

organism-modification


PR:000046297 RAC-alpha serine/threonine-protein kinase phosphorylated 5 (human)
hAKT1/Phos:5

organism-modification


PR:000061529 RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 1 (human)
hAKT1/var:E17K/Phos:1

organism-modification


PR:000061599 RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 2 (human)
hAKT1/var:E17K/Phos:2

organism-modification


PR:000065619 RAC-alpha serine/threonine-protein kinase methylated 1 (human)
hAKT1/Me:1

organism-modification


PR:000068716 RAC-alpha serine/threonine-protein kinase phosphorylated 2 (human)
hAKT1/Phos:2

organism-modification


PR:000072278 RAC-alpha serine/threonine-protein kinase deaminated 1 (human)
hAKT1/Deam:1

organism-gene


PR:P31750 RAC-alpha serine/threonine-protein kinase (mouse)
mAKT1

organism-sequence


PR:P31750-1 RAC-alpha serine/threonine-protein kinase isoform 1 (mouse)
mAKT1/iso:1

organism-modification


PR:000049940 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse)
mAKT1/Phos:3

organism-modification


PR:000049942 RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse)
mAKT1/UnPhos:3

organism-modification


PR:000050596 RAC-alpha serine/threonine-protein kinase phosphorylated 1 (mouse)
mAKT1/Phos:1

organism-gene


PR:P47196 RAC-alpha serine/threonine-protein kinase (rat)
rAKT1

sequence


PR:000002286 RAC-alpha serine/threonine-protein kinase isoform 1
AKT1/iso:1

organism-sequence


PR:P31749-1 RAC-alpha serine/threonine-protein kinase isoform 1 (human)
hAKT1/iso:1

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hAKT1/iso:1/Phos:2
Yes
organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
hAKT1/iso:1/Phos:1
Yes
organism-sequence


PR:P31750-1 RAC-alpha serine/threonine-protein kinase isoform 1 (mouse)
mAKT1/iso:1

modification


PR:000003102 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form
AKT1/iso:1/PhosRes+

modification


PR:000003103 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1
AKT1/iso:1/Phos:1

organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
hAKT1/iso:1/Phos:1
Yes
modification


PR:000027472 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2
AKT1/iso:1/Phos:2

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hAKT1/iso:1/Phos:2
Yes
modification


PR:000049939 RAC-alpha serine/threonine-protein kinase phosphorylated 3
AKT1/Phos:3

organism-modification


PR:000046294 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human)
hAKT1/Phos:3

organism-modification


PR:000049940 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse)
mAKT1/Phos:3

modification


PR:000049941 RAC-alpha serine/threonine-protein kinase unphosphorylated 3
AKT1/UnPhos:3

organism-modification


PR:000049942 RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse)
mAKT1/UnPhos:3

gene


PR:000003912 RAC-beta serine/threonine-protein kinase
AKT2

organism-gene


PR:P31751 RAC-beta serine/threonine-protein kinase (human)
hAKT2

organism-sequence


PR:P31751-1 RAC-beta serine/threonine-protein kinase isoform 1 (human)
hAKT2/iso:1

organism-sequence


PR:P31751-2 RAC-beta serine/threonine-protein kinase isoform h2 (human)
hAKT2/iso:h2

organism-modification


PR:000046298 RAC-beta serine/threonine-protein kinase phosphorylated 1 (human)
hAKT2/Phos:1

organism-modification


PR:000046299 RAC-beta serine/threonine-protein kinase phosphorylated 2 (human)
hAKT2/Phos:2

organism-modification


PR:000046300 RAC-beta serine/threonine-protein kinase phosphorylated 3 (human)
hAKT2/Phos:3

organism-modification


PR:000071625 RAC-beta serine/threonine-protein kinase methylated 1 (human)
hAKT2/Me:1

organism-modification


PR:000079192 RAC-beta serine/threonine-protein kinase cysteinylated 1 (human)
hAKT2/Cyst:1

organism-gene


PR:P47197 RAC-beta serine/threonine-protein kinase (rat)
rAKT2

organism-gene


PR:Q17941 serine/threonine-protein kinase akt-1 (worm)
AKT2 (worm)

organism-sequence


PR:Q17941-1 serine/threonine-protein kinase akt-1 isoform a (worm)
AKT2/iso:a (worm)

organism-sequence


PR:Q17941-2 serine/threonine-protein kinase akt-1 isoform b (worm)
AKT2/iso:b (worm)

organism-sequence


PR:Q17941-3 serine/threonine-protein kinase akt-1 isoform c (worm)
AKT2/iso:c (worm)

organism-gene


PR:Q60823 RAC-beta serine/threonine-protein kinase (mouse)
mAKT2

organism-sequence


PR:Q60823-1 RAC-beta serine/threonine-protein kinase isoform 1 (mouse)
mAKT2/iso:1

organism-modification


PR:000050230 RAC-beta serine/threonine-protein kinase isoform 1 phosphorylated 1 (mouse)
mAKT2/iso:1/Phos:1

organism-modification


PR:000050290 RAC-beta serine/threonine-protein kinase isoform 1 unphosphorylated 1 (mouse)
mAKT2/iso:1/UnPhos:1

organism-gene


PR:Q8INB9 RAC serine/threonine-protein kinase (fruit fly)
fly-AKT2

organism-sequence


PR:Q8INB9-1 RAC serine/threonine-protein kinase isoform C (fruit fly)
fly-AKT2/iso:C

organism-sequence


PR:Q8INB9-2 RAC serine/threonine-protein kinase isoform A (fruit fly)
fly-AKT2/iso:A

sequence


PR:000039286 RAC-beta serine/threonine-protein kinase isoform 1
AKT2/iso:1

organism-sequence


PR:P31751-1 RAC-beta serine/threonine-protein kinase isoform 1 (human)
hAKT2/iso:1

organism-sequence


PR:Q60823-1 RAC-beta serine/threonine-protein kinase isoform 1 (mouse)
mAKT2/iso:1

organism-modification


PR:000050230 RAC-beta serine/threonine-protein kinase isoform 1 phosphorylated 1 (mouse)
mAKT2/iso:1/Phos:1

organism-modification


PR:000050290 RAC-beta serine/threonine-protein kinase isoform 1 unphosphorylated 1 (mouse)
mAKT2/iso:1/UnPhos:1

gene


PR:000003913 RAC-gamma serine/threonine-protein kinase
AKT3

organism-gene


PR:Q63484 RAC-gamma serine/threonine-protein kinase (rat)
rAKT3

organism-gene


PR:Q9WUA6 RAC-gamma serine/threonine-protein kinase (mouse)
mAKT3

organism-sequence


PR:Q9WUA6-1 RAC-gamma serine/threonine-protein kinase isoform 1 (mouse)
mAKT3/iso:1

organism-sequence


PR:Q9WUA6-2 RAC-gamma serine/threonine-protein kinase isoform m2 (mouse)
mAKT3/iso:m2

organism-gene


PR:Q9XTG7 serine/threonine-protein kinase akt-2 (worm)
AKT3 (worm)

organism-sequence


PR:Q9XTG7-1 serine/threonine-protein kinase akt-2 isoform a (worm)
AKT3/iso:a (worm)

organism-sequence


PR:Q9XTG7-2 serine/threonine-protein kinase akt-2 isoform b (worm)
AKT3/iso:b (worm)

organism-gene


PR:Q9Y243 RAC-gamma serine/threonine-protein kinase (human)
hAKT3

organism-sequence


PR:Q9Y243-1 RAC-gamma serine/threonine-protein kinase isoform 1 (human)
hAKT3/iso:1

organism-sequence


PR:Q9Y243-2 RAC-gamma serine/threonine-protein kinase isoform h2 (human)
hAKT3/iso:h2

organism-modification


PR:000046301 RAC-gamma serine/threonine-protein kinase phosphorylated 1 (human)
hAKT3/Phos:1

organism-modification


PR:000046302 RAC-gamma serine/threonine-protein kinase phosphorylated 2 (human)
hAKT3/Phos:2

organism-modification


PR:000046303 RAC-gamma serine/threonine-protein kinase phosphorylated 3 (human)
hAKT3/Phos:3

sequence


PR:000044098 RAC-gamma serine/threonine-protein kinase isoform 1
AKT3/iso:1

organism-sequence


PR:Q9WUA6-1 RAC-gamma serine/threonine-protein kinase isoform 1 (mouse)
mAKT3/iso:1

organism-sequence


PR:Q9Y243-1 RAC-gamma serine/threonine-protein kinase isoform 1 (human)
hAKT3/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027473 hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:16549426
PR:000028994 hAKT1/iso:1/Phos:1
UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046		 acts_upstream_of_or_withinGO:0032869 cellular response to insulin stimulus PMID:8978681
GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
enablesGO:0004672 protein kinase activity PMID:8978681
GO:0004674 protein serine/threonine kinase activity PMID:12138205
GO:0005515 protein binding PMID:12138205
GO:0005515 protein binding PMID:12138205