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Protein Ontology report - AKT kinase
PR:000029189 - http://purl.obolibrary.org/obo/PR_000029189
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000029189   
  PRO nameAKT kinase 
  Synonyms
Other: EXACT:AKT | serine-threonine kinase Akt
  Definition"A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites." [PMID:9736715, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 12                                        
         Sequence3                                                  Organism-Sequence 18                                        
         Modification5                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000029189

AKT kinase

Firm-sspA/SigPep-


"A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites." [PMID:9736715, PRO:CNA]


gene



PR:000002190

RAC-alpha serine/threonine-protein kinase

AKT1


"An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P31749

RAC-alpha serine/threonine-protein kinase (human)

hAKT1


"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human." [PRO:WCB, UniProtKB:P31749]


organism-sequence



PR:000061890

RAC-alpha serine/threonine-protein kinase sequence variant E17K (human)

hAKT1/var:E17K


"A RAC-alpha serine/threonine-protein kinase (human) that has a Lys residue at the position equivalent to Glu-17 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Glu-17, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1500573, Reactome:R-HSA-2219526]


organism-sequence



PR:P31749-1

RAC-alpha serine/threonine-protein kinase isoform 1 (human)

hAKT1/iso:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000027473

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)

hAKT1/iso:1/Phos:2


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]

Yes

organism-modification



PR:000028994

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)

hAKT1/iso:1/Phos:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]

Yes

organism-sequence



PR:P31749-2

RAC-alpha serine/threonine-protein kinase isoform h2 (human)

hAKT1/iso:h2


"A RAC-alpha serine/threonine-protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31749-2." [PRO:DNx, UniProtKB:P31749]


organism-modification



PR:000046294

RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human)

hAKT1/Phos:3


"A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in human. UniProtKB:P31749, Ser-473, MOD:00046." [PRO:CNA, PRO:DNx, Reactome:R-HSA-377265]


organism-modification



PR:000046295

RAC-alpha serine/threonine-protein kinase phosphorylated 4 (human)

hAKT1/Phos:4


"A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-308 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Thr-308, MOD:00047." [PRO:DNx, Reactome:R-HSA-198634]


organism-modification



PR:000046296

RAC-alpha serine/threonine-protein kinase phosphorylated 1 (human)

hAKT1/Phos:1


"A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-308, and phosphoserine at position 473 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Thr-308, MOD:00047|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-198356, Reactome:R-HSA-198357, Reactome:R-HSA-199430]


organism-modification



PR:000046297

RAC-alpha serine/threonine-protein kinase phosphorylated 5 (human)

hAKT1/Phos:5


"A RAC-alpha serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphotyrosine at positions 315 and 326 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Tyr-315/Tyr-326, MOD:00048." [PRO:DNx, Reactome:R-HSA-8848757]


organism-modification



PR:000061529

RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 1 (human)

hAKT1/var:E17K/Phos:1


"A RAC-alpha serine/threonine-protein kinase (human) that has a Lys residue at the position equivalent to Glu-17 of the amino acid sequence represented by UniProtKB:P31749-1 and that has been phosphorylated on the residue at the position equivalent to Ser-473. Example: UniProtKB:P31749-1, Glu-17, CHEBI:29967|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-2243944]


organism-modification



PR:000061599

RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 2 (human)

hAKT1/var:E17K/Phos:2


"A RAC-alpha serine/threonine-protein kinase (human) that has a Lys residue at the position equivalent to Glu-17 of the amino acid sequence represented by UniProtKB:P31749-1 and that has been phosphorylated on the residues at the positions equivalent to Thr-308 and Ser-473. Example: UniProtKB:P31749-1, Glu-17, CHEBI:29967|Thr-308, MOD:00047|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-2243935, Reactome:R-HSA-2399994]


organism-modification



PR:000065619

RAC-alpha serine/threonine-protein kinase methylated 1 (human)

hAKT1/Me:1


"A RAC-alpha serine/threonine-protein kinase (human) that has been methylated on the residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Cys-60, MOD:00660." [IEDB_epitope:1052366, PRO:DNx]


organism-modification



PR:000068716

RAC-alpha serine/threonine-protein kinase phosphorylated 2 (human)

hAKT1/Phos:2


"A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-371 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Thr-371, MOD:00047." [IEDB_epitope:2147736, PRO:DNx]


organism-modification



PR:000072278

RAC-alpha serine/threonine-protein kinase deaminated 1 (human)

hAKT1/Deam:1


"A RAC-alpha serine/threonine-protein kinase (human) that has been deaminated on the residue at the position equivalent to Gln-59 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Gln-59, MOD:00685." [IEDB_epitope:931423, PRO:DNx]


organism-gene



PR:P31750

RAC-alpha serine/threonine-protein kinase (mouse)

mAKT1


"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of mouse." [OMA:P31750, PRO:DNx]


organism-sequence



PR:P31750-1

RAC-alpha serine/threonine-protein kinase isoform 1 (mouse)

mAKT1/iso:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-modification



PR:000049940

RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse)

mAKT1/Phos:3


"A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in mouse. UniProtKB:P31750, Ser-473, MOD:00046." [PMID:27994061, PRO:LN]


organism-modification



PR:000049942

RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse)

mAKT1/UnPhos:3


"A RAC-alpha serine/threonine-protein kinase unphosphorylated 3 in mouse. UniProtKB:P31750, Ser-473, PR:000026291." [PMID:27994061, PRO:LN]


organism-modification



PR:000050596

RAC-alpha serine/threonine-protein kinase phosphorylated 1 (mouse)

mAKT1/Phos:1


"A RAC-alpha serine/threonine-protein kinase (mouse) that has been phosphorylated on the residue at the position equivalent to Thr-308, and phosphoserine at position 473 of the amino acid sequence represented by UniProtKB:P31750. UniProtKB:P31750, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:31915252, PRO:LN]


organism-gene



PR:P47196

RAC-alpha serine/threonine-protein kinase (rat)

rAKT1


"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of rat." [OMA:P47196, PRO:DNx]


sequence



PR:000002286

RAC-alpha serine/threonine-protein kinase isoform 1

AKT1/iso:1


"A RAC-alpha serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31749-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P31749-1

RAC-alpha serine/threonine-protein kinase isoform 1 (human)

hAKT1/iso:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000027473

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)

hAKT1/iso:1/Phos:2


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]

Yes

organism-modification



PR:000028994

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)

hAKT1/iso:1/Phos:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]

Yes

organism-sequence



PR:P31750-1

RAC-alpha serine/threonine-protein kinase isoform 1 (mouse)

mAKT1/iso:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


modification



PR:000003102

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form

AKT1/iso:1/PhosRes+


"A RAC-alpha serine/threonine-protein kinase isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003103

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1

AKT1/iso:1/Phos:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form that is an active kinase form. Example: UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PID:cd8tcrpathway, PID:pi3kciaktpathway, PID:ptp1bpathway, PID:tcrpathway, PMID:12586360, PRO:JAN]


organism-modification



PR:000028994

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)

hAKT1/iso:1/Phos:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]

Yes

modification



PR:000027472

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2

AKT1/iso:1/Phos:2


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form that is the actived form (see PR:000003103), which has been further phosphorylated by autocatalysis in trans at two sites that lie in the characteristic AKT substrate motif RxRxx[ST]. Example: UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]


organism-modification



PR:000027473

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)

hAKT1/iso:1/Phos:2


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]

Yes

modification



PR:000049939

RAC-alpha serine/threonine-protein kinase phosphorylated 3

AKT1/Phos:3


"A RAC-alpha serine/threonine-protein kinase that has been phosphorylated on the residue at the position equivalent to Ser-473 of the amino acid sequence represented by UniProtKB:P31749. Example: UniProtKB:P31749, Ser-473, MOD:00046." [PMID:27994061, PRO:LN, Reactome:R-HSA-377265]


organism-modification



PR:000046294

RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human)

hAKT1/Phos:3


"A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in human. UniProtKB:P31749, Ser-473, MOD:00046." [PRO:CNA, PRO:DNx, Reactome:R-HSA-377265]


organism-modification



PR:000049940

RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse)

mAKT1/Phos:3


"A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in mouse. UniProtKB:P31750, Ser-473, MOD:00046." [PMID:27994061, PRO:LN]


modification



PR:000049941

RAC-alpha serine/threonine-protein kinase unphosphorylated 3

AKT1/UnPhos:3


"A RAC-alpha serine/threonine-protein kinase that lacks phosphorylation at the position equivalent to Ser-473 of the amino acid sequence represented by UniProtKB:P31749. Example: UniProtKB:P31749, Ser-473, PR:000026291." [PMID:27994061, PRO:LN]


organism-modification



PR:000049942

RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse)

mAKT1/UnPhos:3


"A RAC-alpha serine/threonine-protein kinase unphosphorylated 3 in mouse. UniProtKB:P31750, Ser-473, PR:000026291." [PMID:27994061, PRO:LN]


gene



PR:000003912

RAC-beta serine/threonine-protein kinase

AKT2


"An AKT kinase that is a translation product of the human AKT2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P31751

RAC-beta serine/threonine-protein kinase (human)

hAKT2


"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human." [PRO:CNA, UniProtKB:P31751]


organism-sequence



PR:P31751-1

RAC-beta serine/threonine-protein kinase isoform 1 (human)

hAKT2/iso:1


"A RAC-beta serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P31751-2

RAC-beta serine/threonine-protein kinase isoform h2 (human)

hAKT2/iso:h2


"A RAC-beta serine/threonine-protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31751-2." [PRO:DNx, UniProtKB:P31751]


organism-modification



PR:000046298

RAC-beta serine/threonine-protein kinase phosphorylated 1 (human)

hAKT2/Phos:1


"A RAC-beta serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-474 of the amino acid sequence represented by UniProtKB:P31751. UniProtKB:P31751, Ser-474, MOD:00046." [PRO:DNx, Reactome:R-HSA-2317312]


organism-modification



PR:000046299

RAC-beta serine/threonine-protein kinase phosphorylated 2 (human)

hAKT2/Phos:2


"A RAC-beta serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-309 of the amino acid sequence represented by UniProtKB:P31751. UniProtKB:P31751, Thr-309, MOD:00047." [PRO:DNx, Reactome:R-HSA-202066]


organism-modification



PR:000046300

RAC-beta serine/threonine-protein kinase phosphorylated 3 (human)

hAKT2/Phos:3


"A RAC-beta serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-309, and phosphoserine at position 474 of the amino acid sequence represented by UniProtKB:P31751. UniProtKB:P31751, Thr-309, MOD:00047|Ser-474, MOD:00046." [PRO:DNx, Reactome:R-HSA-202056, Reactome:R-HSA-202087]


organism-modification



PR:000071625

RAC-beta serine/threonine-protein kinase methylated 1 (human)

hAKT2/Me:1


"A RAC-beta serine/threonine-protein kinase (human) that has been methylated on the residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:P31751-1. Example: UniProtKB:P31751-1, Cys-60, MOD:00660." [IEDB_epitope:1052336, PRO:DNx]


organism-modification



PR:000079192

RAC-beta serine/threonine-protein kinase cysteinylated 1 (human)

hAKT2/Cyst:1


"A RAC-beta serine/threonine-protein kinase (human) that has been cysteinylated on the residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:P31751-1. Example: UniProtKB:P31751-1, Cys-60, MOD:00765." [IEDB_epitope:884166, PRO:DNx]


organism-gene



PR:P47197

RAC-beta serine/threonine-protein kinase (rat)

rAKT2


"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of rat." [OMA:P47197, PRO:DNx]


organism-gene



PR:Q17941

serine/threonine-protein kinase akt-1 (worm)

AKT2 (worm)


"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of worm." [OMA:Q17941, PRO:DNx]


organism-sequence



PR:Q17941-1

serine/threonine-protein kinase akt-1 isoform a (worm)

AKT2/iso:a (worm)


"A serine/threonine-protein kinase akt-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17941-1." [PRO:DNx, UniProtKB:Q17941]


organism-sequence



PR:Q17941-2

serine/threonine-protein kinase akt-1 isoform b (worm)

AKT2/iso:b (worm)


"A serine/threonine-protein kinase akt-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17941-2." [PRO:DNx, UniProtKB:Q17941]


organism-sequence



PR:Q17941-3

serine/threonine-protein kinase akt-1 isoform c (worm)

AKT2/iso:c (worm)


"A serine/threonine-protein kinase akt-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17941-3." [PRO:DNx, UniProtKB:Q17941]


organism-gene



PR:Q60823

RAC-beta serine/threonine-protein kinase (mouse)

mAKT2


"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of mouse." [OMA:Q60823, PRO:DNx]


organism-sequence



PR:Q60823-1

RAC-beta serine/threonine-protein kinase isoform 1 (mouse)

mAKT2/iso:1


"A RAC-beta serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000050230

RAC-beta serine/threonine-protein kinase isoform 1 phosphorylated 1 (mouse)

mAKT2/iso:1/Phos:1


"A RAC-beta serine/threonine-protein kinase isoform 1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-474 of the amino acid sequence represented by UniProtKB:Q60823-1. UniProtKB:Q60823-1, Ser-474, MOD:00046." [PMID:31548312, PRO:HJD]


organism-modification



PR:000050290

RAC-beta serine/threonine-protein kinase isoform 1 unphosphorylated 1 (mouse)

mAKT2/iso:1/UnPhos:1


"A RAC-beta serine/threonine-protein kinase isoform 1 (mouse) that lacks phosphorylation at the position equivalent to Ser-474 of the amino acid sequence represented by UniProtKB:Q60823-1. UniProtKB:Q60823-1, Ser-474, PR:000026291." [PRO:HJD]


organism-gene



PR:Q8INB9

RAC serine/threonine-protein kinase (fruit fly)

fly-AKT2


"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of fruit fly." [OMA:Q8INB9, PRO:DNx]


organism-sequence



PR:Q8INB9-1

RAC serine/threonine-protein kinase isoform C (fruit fly)

fly-AKT2/iso:C


"A RAC serine/threonine-protein kinase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8INB9-1." [PRO:DNx, UniProtKB:Q8INB9]


organism-sequence



PR:Q8INB9-2

RAC serine/threonine-protein kinase isoform A (fruit fly)

fly-AKT2/iso:A


"A RAC serine/threonine-protein kinase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8INB9-2." [PRO:DNx, UniProtKB:Q8INB9]


sequence



PR:000039286

RAC-beta serine/threonine-protein kinase isoform 1

AKT2/iso:1


"A RAC-beta serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31751-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P31751-1

RAC-beta serine/threonine-protein kinase isoform 1 (human)

hAKT2/iso:1


"A RAC-beta serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q60823-1

RAC-beta serine/threonine-protein kinase isoform 1 (mouse)

mAKT2/iso:1


"A RAC-beta serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000050230

RAC-beta serine/threonine-protein kinase isoform 1 phosphorylated 1 (mouse)

mAKT2/iso:1/Phos:1


"A RAC-beta serine/threonine-protein kinase isoform 1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-474 of the amino acid sequence represented by UniProtKB:Q60823-1. UniProtKB:Q60823-1, Ser-474, MOD:00046." [PMID:31548312, PRO:HJD]


organism-modification



PR:000050290

RAC-beta serine/threonine-protein kinase isoform 1 unphosphorylated 1 (mouse)

mAKT2/iso:1/UnPhos:1


"A RAC-beta serine/threonine-protein kinase isoform 1 (mouse) that lacks phosphorylation at the position equivalent to Ser-474 of the amino acid sequence represented by UniProtKB:Q60823-1. UniProtKB:Q60823-1, Ser-474, PR:000026291." [PRO:HJD]


gene



PR:000003913

RAC-gamma serine/threonine-protein kinase

AKT3


"An AKT kinase that is a translation product of the human AKT3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q63484

RAC-gamma serine/threonine-protein kinase (rat)

rAKT3


"A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of rat." [OMA:Q63484, PRO:DNx]


organism-gene



PR:Q9WUA6

RAC-gamma serine/threonine-protein kinase (mouse)

mAKT3


"A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of mouse." [OMA:Q9WUA6, PRO:DNx]


organism-sequence



PR:Q9WUA6-1

RAC-gamma serine/threonine-protein kinase isoform 1 (mouse)

mAKT3/iso:1


"A RAC-gamma serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9WUA6-2

RAC-gamma serine/threonine-protein kinase isoform m2 (mouse)

mAKT3/iso:m2


"A RAC-gamma serine/threonine-protein kinase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WUA6-2." [PRO:DNx, UniProtKB:Q9WUA6]


organism-gene



PR:Q9XTG7

serine/threonine-protein kinase akt-2 (worm)

AKT3 (worm)


"A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of worm." [OMA:Q9XTG7, PRO:DNx]


organism-sequence



PR:Q9XTG7-1

serine/threonine-protein kinase akt-2 isoform a (worm)

AKT3/iso:a (worm)


"A serine/threonine-protein kinase akt-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9XTG7-1." [PRO:DNx, UniProtKB:Q9XTG7]


organism-sequence



PR:Q9XTG7-2

serine/threonine-protein kinase akt-2 isoform b (worm)

AKT3/iso:b (worm)


"A serine/threonine-protein kinase akt-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9XTG7-2." [PRO:DNx, UniProtKB:Q9XTG7]


organism-gene



PR:Q9Y243

RAC-gamma serine/threonine-protein kinase (human)

hAKT3


"A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y243]


organism-sequence



PR:Q9Y243-1

RAC-gamma serine/threonine-protein kinase isoform 1 (human)

hAKT3/iso:1


"A RAC-gamma serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9Y243-2

RAC-gamma serine/threonine-protein kinase isoform h2 (human)

hAKT3/iso:h2


"A RAC-gamma serine/threonine-protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y243-2." [PRO:DNx, UniProtKB:Q9Y243]


organism-modification



PR:000046301

RAC-gamma serine/threonine-protein kinase phosphorylated 1 (human)

hAKT3/Phos:1


"A RAC-gamma serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-472 of the amino acid sequence represented by UniProtKB:Q9Y243. UniProtKB:Q9Y243, Ser-472, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009363]


organism-modification



PR:000046302

RAC-gamma serine/threonine-protein kinase phosphorylated 2 (human)

hAKT3/Phos:2


"A RAC-gamma serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-305 of the amino acid sequence represented by UniProtKB:Q9Y243. UniProtKB:Q9Y243, Thr-305, MOD:00047." [PRO:DNx, Reactome:R-HSA-3009370]


organism-modification



PR:000046303

RAC-gamma serine/threonine-protein kinase phosphorylated 3 (human)

hAKT3/Phos:3


"A RAC-gamma serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-305, and phosphoserine at position 472 of the amino acid sequence represented by UniProtKB:Q9Y243. UniProtKB:Q9Y243, Thr-305, MOD:00047|Ser-472, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009365, Reactome:R-HSA-3009367]


sequence



PR:000044098

RAC-gamma serine/threonine-protein kinase isoform 1

AKT3/iso:1


"A RAC-gamma serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y243-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q9WUA6-1

RAC-gamma serine/threonine-protein kinase isoform 1 (mouse)

mAKT3/iso:1


"A RAC-gamma serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9Y243-1

RAC-gamma serine/threonine-protein kinase isoform 1 (human)

hAKT3/iso:1


"A RAC-gamma serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027473 hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:16549426
PR:000028994 hAKT1/iso:1/Phos:1
UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046
acts_upstream_of_or_withinGO:0032869 cellular response to insulin stimulus PMID:8978681
GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
enablesGO:0004672 protein kinase activity PMID:8978681
GO:0004674 protein serine/threonine kinase activity PMID:12138205
GO:0005515 protein binding PMID:12138205
GO:0005515 protein binding PMID:12138205