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Protein Ontology report - pro-neuregulin-1, membrane-bound isoform
PR:000029649 - http://purl.obolibrary.org/obo/PR_000029649
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000029649   
  PRO namepro-neuregulin-1, membrane-bound isoform 
  Synonyms
PRO-Short-label: EXACT:NRG1
Gene-based: RELATED:GGF | HGL | HRGA | NDF | SMDF
Other: EXACT:acetylcholine receptor inducing activity | glial growth factor | heregulin | neu differentiation factor | pro-NRG1 | sensory and motor neuron derived factor
  Definition"A protein that is a translation product of the human NRG1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence7                                                  Organism-Sequence 35                                        
         Modification2                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000029649 pro-neuregulin-1, membrane-bound isoform
NRG1

organism-gene


PR:P43322 pro-neuregulin-1, membrane-bound isoform (rat)
rNRG1

organism-sequence


PR:P43322-1 neuregulin-1 type I-beta4a (rat)
rNRG1/iso:Ibeta4a

organism-sequence


PR:G3V7F0 neuregulin-1 type I-beta4a sequence variant V386I (rat)
rNRG1/iso:Ibeta4a/var:V386I

organism-sequence


PR:P43322-2 pro-neuregulin-1, membrane-bound isoform isoform rAlpha2A (rat)
rNRG1/iso:rAlpha2A

organism-sequence


PR:P43322-3 pro-neuregulin-1, membrane-bound isoform isoform rAlpha2B (rat)
rNRG1/iso:rAlpha2B

organism-sequence


PR:P43322-4 pro-neuregulin-1, membrane-bound isoform isoform rAlpha2C (rat)
rNRG1/iso:rAlpha2C

organism-sequence


PR:P43322-5 neuregulin-1 type I-beta1a (rat)
rNRG1/iso:Ibeta1a

organism-sequence


PR:P43322-6 pro-neuregulin-1, membrane-bound isoform isoform rBeta2 (rat)
rNRG1/iso:rBeta2

organism-sequence


PR:P43322-7 pro-neuregulin-1, membrane-bound isoform isoform rBetA2A (rat)
rNRG1/iso:rBetA2A

organism-sequence


PR:P43322-8 pro-neuregulin-1, membrane-bound isoform isoform rBeta3 (rat)
rNRG1/iso:rBeta3

organism-sequence


PR:Q3S2T6 neuregulin-1 type III-beta3 (rat)
rNRG1/iso:IIIbeta3

organism-gene


PR:Q02297 pro-neuregulin-1, membrane-bound isoform (human)
hNRG1

organism-sequence


PR:A0A494C1B5 neuregulin-1 type III-beta1c (human)
hNRG1/iso:IIIbeta1c

organism-sequence


PR:Q02297-1 neuregulin-1 type I-alpha2a (human)
hNRG1/iso:Ialpha2a

organism-sequence


PR:Q02297-10 neuregulin-1 type III-beta3 (human)
hNRG1/iso:IIIbeta3

organism-sequence


PR:Q02297-11 pro-neuregulin-1, membrane-bound isoform isoform h11 (human)
hNRG1/iso:h11

organism-sequence


PR:Q02297-12 pro-neuregulin-1, membrane-bound isoform isoform h12 (human)
hNRG1/iso:h12

organism-sequence


PR:Q02297-2 pro-neuregulin-1, membrane-bound isoform isoform h2 (human)
hNRG1/iso:h2

organism-sequence


PR:Q02297-3 pro-neuregulin-1, membrane-bound isoform isoform h3 (human)
hNRG1/iso:h3

organism-sequence


PR:Q02297-4 pro-neuregulin-1, membrane-bound isoform isoform h4 (human)
hNRG1/iso:h4

organism-sequence


PR:Q02297-6 neuregulin-1 type I-beta1a (human)
hNRG1/iso:Ibeta1a

organism-sequence


PR:Q02297-7 neuregulin-1 type beta2 (human)
hNRG1/iso:beta2

organism-sequence


PR:Q02297-8 pro-neuregulin-1, membrane-bound isoform isoform h8 (human)
hNRG1/iso:h8

organism-sequence


PR:Q02297-9 pro-neuregulin-1, membrane-bound isoform isoform h9 (human)
hNRG1/iso:h9

organism-gene


PR:Q05199 pro-neuregulin-1, membrane-bound isoform (chicken)
chick-NRG1

organism-sequence


PR:Q05199-1 pro-neuregulin-1, membrane-bound isoform isoform 1 (chicken)
chick-NRG1/iso:1

organism-sequence


PR:Q05199-2 pro-neuregulin-1, membrane-bound isoform isoform 2 (chicken)
chick-NRG1/iso:2

organism-sequence


PR:Q05199-3 pro-neuregulin-1, membrane-bound isoform isoform 3 (chicken)
chick-NRG1/iso:3

organism-sequence


PR:Q05199-4 pro-neuregulin-1, membrane-bound isoform isoform 4 (chicken)
chick-NRG1/iso:4

organism-gene


PR:Q6DR98 pro-neuregulin-1, membrane-bound isoform (mouse)
mNRG1
Yes
organism-sequence


PR:000044837 neuregulin-1 type I-beta4a (mouse)
mNRG1/iso:Ibeta4a

organism-modification


PR:000044838 neuregulin-1 type I-beta4a transmembrane precursor (mouse)
mNRG1/iso:Ibeta4a/precursor

organism-modification


PR:000044839 neuregulin-1 type I-beta4a mature form (mouse)
mNRG1/iso:Ibeta4a/mature

union


PR:000044840 neuregulin-1 type III (mouse)
mNRG1/iso:III
Yes




PR:A0A140LIG9 neuregulin-1 type III-beta1c (mouse)





PR:A0A5F8MPT0 neuregulin-1 type III-beta3 (mouse)





PR:Q6DR99 neuregulin-1 type III-beta1a (mouse)

organism-sequence


PR:A0A140LIG9 neuregulin-1 type III-beta1c (mouse)
mNRG1/iso:IIIbeta1c

organism-sequence


PR:Q3URY7 neuregulin-1 type III-beta1c sequence variant S499Y (mouse)
mNRG1/iso:IIIbeta1c/var:S499Y

organism-modification


PR:000044825 neuregulin-1 type III-beta1c transmembrane precursor (mouse)
mNRG1/iso:IIIbeta1c/precursor

organism-sequence


PR:A0A140LIP8 neuregulin-1 type beta2 (mouse)
mNRG1/iso:beta2

organism-sequence


PR:A0A140LJC1 neuregulin-1 type I-alpha2a (mouse)
mNRG1/iso:Ialpha2a

organism-modification


PR:000044842 neuregulin-1 type I-alpha2a transmembrane precursor (mouse)
mNRG1/iso:Ialpha2a/precursor

organism-sequence


PR:A0A5F8MPT0 neuregulin-1 type III-beta3 (mouse)
mNRG1/iso:IIIbeta3

organism-sequence


PR:Q8BX76 neuregulin-1 type III-beta3 sequence variant D40N (mouse)
mNRG1/iso:IIIbeta3/var:D40N

organism-sequence


PR:Q6DR98-1 neuregulin-1 type I-beta1a (mouse)
mNRG1/iso:Ibeta1a

organism-modification


PR:000044821 neuregulin-1 type I-beta1a mature form (mouse)
mNRG1/iso:Ibeta1a/mature
Yes
organism-modification


PR:000044823 neuregulin-1 type I-beta1a transmembrane precursor (mouse)
mNRG1/iso:Ibeta1a/precursor

organism-sequence


PR:Q6DR99 neuregulin-1 type III-beta1a (mouse)
mNRG1/iso:IIIbeta1a
Yes
organism-modification


PR:000044824 neuregulin-1 type III-beta1a transmembrane precursor (mouse)
mNRG1/iso:IIIbeta1a/precursor
Yes
organism-modification


PR:000044843 neuregulin-1 intracellular domain (mouse)
mNRG1/Clv:intracellular
Yes
sequence


PR:000044820 neuregulin-1 type I-beta1a
NRG1/iso:Ibeta1a

organism-sequence


PR:P43322-5 neuregulin-1 type I-beta1a (rat)
rNRG1/iso:Ibeta1a

organism-sequence


PR:Q02297-6 neuregulin-1 type I-beta1a (human)
hNRG1/iso:Ibeta1a

organism-sequence


PR:Q6DR98-1 neuregulin-1 type I-beta1a (mouse)
mNRG1/iso:Ibeta1a

organism-modification


PR:000044821 neuregulin-1 type I-beta1a mature form (mouse)
mNRG1/iso:Ibeta1a/mature
Yes
organism-modification


PR:000044823 neuregulin-1 type I-beta1a transmembrane precursor (mouse)
mNRG1/iso:Ibeta1a/precursor

sequence


PR:000044822 neuregulin-1 type III-beta3
NRG1/iso:IIIbeta3

organism-sequence


PR:A0A5F8MPT0 neuregulin-1 type III-beta3 (mouse)
mNRG1/iso:IIIbeta3

organism-sequence


PR:Q8BX76 neuregulin-1 type III-beta3 sequence variant D40N (mouse)
mNRG1/iso:IIIbeta3/var:D40N

organism-sequence


PR:Q02297-10 neuregulin-1 type III-beta3 (human)
hNRG1/iso:IIIbeta3

organism-sequence


PR:Q3S2T6 neuregulin-1 type III-beta3 (rat)
rNRG1/iso:IIIbeta3

sequence


PR:000060231 neuregulin-1 type I-alpha2a
NRG1/iso:Ialpha2a

organism-sequence


PR:A0A140LJC1 neuregulin-1 type I-alpha2a (mouse)
mNRG1/iso:Ialpha2a

organism-modification


PR:000044842 neuregulin-1 type I-alpha2a transmembrane precursor (mouse)
mNRG1/iso:Ialpha2a/precursor

organism-sequence


PR:Q02297-1 neuregulin-1 type I-alpha2a (human)
hNRG1/iso:Ialpha2a

sequence


PR:000060232 neuregulin-1 type III-beta1c
NRG1/iso:IIIbeta1c

organism-sequence


PR:A0A140LIG9 neuregulin-1 type III-beta1c (mouse)
mNRG1/iso:IIIbeta1c

organism-sequence


PR:Q3URY7 neuregulin-1 type III-beta1c sequence variant S499Y (mouse)
mNRG1/iso:IIIbeta1c/var:S499Y

organism-modification


PR:000044825 neuregulin-1 type III-beta1c transmembrane precursor (mouse)
mNRG1/iso:IIIbeta1c/precursor

organism-sequence


PR:A0A494C1B5 neuregulin-1 type III-beta1c (human)
hNRG1/iso:IIIbeta1c

sequence


PR:000060233 neuregulin-1 type beta2
NRG1/iso:beta2

organism-sequence


PR:A0A140LIP8 neuregulin-1 type beta2 (mouse)
mNRG1/iso:beta2

organism-sequence


PR:Q02297-7 neuregulin-1 type beta2 (human)
hNRG1/iso:beta2

sequence


PR:000060238 neuregulin-1 type I-alpha2b
NRG1/iso:Ialpha2b

sequence


PR:000060239 neuregulin-1 type I-beta3
NRG1/iso:Ibeta3

modification


PR:000029650 pro-neuregulin-1, membrane-bound isoform, initiator methionine removed form
NRG1/InitMet-

modification


PR:000029651 pro-neuregulin-1, membrane-bound isoform proteolytic cleavage product
NRG1/ClvPrd

organism-modification


PR:000044821 neuregulin-1 type I-beta1a mature form (mouse)
mNRG1/iso:Ibeta1a/mature
Yes
organism-modification


PR:000044839 neuregulin-1 type I-beta4a mature form (mouse)
mNRG1/iso:Ibeta4a/mature

organism-modification


PR:000044843 neuregulin-1 intracellular domain (mouse)
mNRG1/Clv:intracellular
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044821 mNRG1/iso:Ibeta1a/mature acts_upstream_of_or_withinGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:3625788; PMID:11116142
located_inGO:0005576 extracellular region MGI_ref:3625788; PMID:11116142
PR:000044824 mNRG1/iso:IIIbeta1a/precursor
UniProtKB:Q6DR99, 1-700		 acts_upstream_of_or_withinGO:0045773 positive regulation of axon extension MGI_ref:4461331; PMID:20610754
PR:000044840 mNRG1/iso:III acts_upstream_of_or_withinGO:0001964 startle response MGI_ref:3803029; PMID:18596162
GO:0008366 axon ensheathment MGI_ref:3590355; PMID:16129398
GO:0031643 positive regulation of myelination MGI_ref:4420197; PMID:18080294
GO:0031643 positive regulation of myelination MGI_ref:4420197; PMID:18080294
NOT GO:0048709 oligodendrocyte differentiation MGI_ref:4420197; PMID:18080294
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction MGI_ref:3796800; PMID:18458158
GO:0060999 positive regulation of dendritic spine development MGI_ref:4461331; PMID:20610754
GO:0060999 positive regulation of dendritic spine development MGI_ref:4461331; PMID:20610754
GO:2000010 positive regulation of protein localization to cell surface MGI_ref:3796800; PMID:18458158
located_inGO:0030424 axon MGI_ref:4461331; PMID:20610754
GO:0030424 axon MGI_ref:4461331; PMID:20610754
GO:0030425 dendrite MGI_ref:4461331; PMID:20610754
GO:0030673 axolemma MGI_ref:3796800; PMID:18458158
GO:0044297 cell body MGI_ref:4461331; PMID:20610754
PR:000044843 mNRG1/Clv:intracellular
Example: UniProtKB:Q6DR99, 326-700		 acts_upstream_of_or_withinGO:0022008 neurogenesis MGI_ref:4438553; PMID:19781646
GO:0022008 neurogenesis MGI_ref:4438553; PMID:19781646
NOT GO:0045773 positive regulation of axon extension MGI_ref:4461331; PMID:20610754
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:4461331; PMID:20610754
enablesGO:0005515 protein binding with PR:O54941 Baf57 MGI_ref:4438553; PMID:19781646
located_inGO:0005634 nucleus MGI_ref:4461331; PMID:20610754
PR:Q6DR98 mNRG1 acts_upstream_of_or_withinNOT GO:0031643 positive regulation of myelination MGI_ref:3042336; PMID:15044753
located_inGO:0009897 external side of plasma membrane MGI_ref:3625788; PMID:11116142
PR:Q6DR99 mNRG1/iso:IIIbeta1a acts_upstream_of_or_withinGO:0031643 positive regulation of myelination MGI_ref:3042336; PMID:15044753