back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - aurora kinase
PR:000035365 - http://purl.obolibrary.org/obo/PR_000035365
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035365   
  PRO nameaurora kinase 
  Synonyms
PRO-Short-label: EXACT:fam:AURK
  Definition"A protein that is a serine-threonine protein kinase that controls several aspects of cell division. It contains a copy of the Protein kinase domain (Pfam:PF00069)." [PIRSF:PIRSF501130, PMID:18662747, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 18                                        
         Sequence0                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF501130
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000035365

aurora kinase

fam:AURK


"A protein that is a serine-threonine protein kinase that controls several aspects of cell division. It contains a copy of the Protein kinase domain (Pfam:PF00069)." [PIRSF:PIRSF501130, PMID:18662747, PRO:CNA]


gene



PR:000004515

aurora kinase A

AURKA


"An aurora kinase that is a translation product of the human AURKA gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O14965

aurora kinase A (human)

hAURKA


"An aurora kinase A that is encoded in the genome of human." [PRO:KER]

Yes

organism-modification



PR:000045573

aurora kinase A phosphorylated 1 (human)

hAURKA/Phos:1


"An aurora kinase A (human) that has been phosphorylated at Thr-288. UniProtKB:O14965, Thr-288, MOD:00047." [iPTMnet:O14965, PMID:11039908]


organism-modification



PR:000046439

aurora kinase A sumoylated 1 (human)

hAURKA/Sumo:1


"An aurora kinase A (human) that has been post-translationally modified to include sumoylated lysine at position 258 of the amino acid sequence represented by UniProtKB:O14965. UniProtKB:O14965, Lys-258, MOD:01149." [PRO:DNx, Reactome:R-HSA-4655367]


organism-modification



PR:000064814

aurora kinase A ubiquitinated form (human)

hAURKA/UbiqLys+


"An aurora kinase A (human) that includes at least one ubiquitinated lysine. UniProtKB:O14965, MOD:01148." [PRO:DNx, Reactome:R-HSA-8854040]


organism-modification



PR:000084713

aurora kinase A hydroxylated 1 (human)

hAURKA/Hy:1


"An aurora kinase A (human) that has been hydroxylated on the residue at the position equivalent to Trp-277 of the amino acid sequence represented by UniProtKB:O14965. UniProtKB:O14965, Trp-277, MOD:01622." [IEDB_epitope:1319516, PRO:DNx]


organism-gene



PR:P59241

aurora kinase A (rat)

rAURKA


"An aurora kinase A that is encoded in the genome of rat." [PRO:DAN]


organism-gene



PR:P97477

aurora kinase A (mouse)

mAURKA


"An aurora kinase A that is encoded in the genome of mouse." [OMA:P97477, PRO:DNx]


organism-sequence



PR:P97477-1

aurora kinase A isoform m1 (mouse)

mAURKA/iso:m1


"An aurora kinase A (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97477-1." [PRO:DNx, UniProtKB:P97477]


organism-sequence



PR:P97477-2

aurora kinase A isoform m2 (mouse)

mAURKA/iso:m2


"An aurora kinase A (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97477-2." [PRO:DNx, UniProtKB:P97477]


organism-gene



PR:Q54WX4

aurora kinase (Dictyostelium discoideum)

Dicty-AURKA


"An aurora kinase A that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54WX4, PRO:DNx]


gene



PR:000004517

aurora kinase B

AURKB


"An aurora kinase that is a translation product of the human AURKB gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:000060242

serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe)

Spom-AURKB


"An aurora kinase B that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN]


organism-gene



PR:O59790

aurora kinase (Schizosaccharomyces pombe 972h-)

Spom972h-AURKB


"An aurora kinase B that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]


organism-gene



PR:O01427

aurora/IPL1-related protein kinase 2 (worm)

AURKB (worm)


"An aurora kinase B that is encoded in the genome of worm." [OMA:O01427, PRO:DNx]


organism-gene



PR:O55099

aurora kinase B (rat)

rAURKB


"An aurora kinase B that is encoded in the genome of rat." [OMA:O55099, PRO:DNx]


organism-gene



PR:O59790

aurora kinase (Schizosaccharomyces pombe 972h-)

Spom972h-AURKB


"An aurora kinase B that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]


organism-gene



PR:O70126

aurora kinase B (mouse)

mAURKB


"An aurora kinase B that is encoded in the genome of mouse." [OMA:O70126, PRO:DNx]


organism-gene



PR:Q6DE08

aurora kinase B-A (frog)

frog-AURKB


"An aurora kinase B that is encoded in the genome of frog." [OMA:Q6DE08, PRO:DNx]


organism-gene



PR:Q6NW76

aurora kinase B (zebrafish)

z-AURKB


"An aurora kinase B that is encoded in the genome of zebrafish." [OMA:Q6NW76, PRO:DAN]


organism-gene



PR:Q96GD4

aurora kinase B (human)

hAURKB


"An aurora kinase B that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER]

Yes

organism-sequence



PR:Q96GD4-1

aurora kinase B isoform h1 (human)

hAURKB/iso:h1


"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-1." [PRO:DNx, UniProtKB:Q96GD4]


organism-sequence



PR:Q96GD4-2

aurora kinase B isoform h2 (human)

hAURKB/iso:h2


"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-2." [PRO:DNx, UniProtKB:Q96GD4]


organism-sequence



PR:Q96GD4-3

aurora kinase B isoform h3 (human)

hAURKB/iso:h3


"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-3." [PRO:DNx, UniProtKB:Q96GD4]


organism-sequence



PR:Q96GD4-4

aurora kinase B isoform h4 (human)

hAURKB/iso:h4


"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-4." [PRO:DNx, UniProtKB:Q96GD4]


organism-sequence



PR:Q96GD4-5

aurora kinase B isoform h5 (human)

hAURKB/iso:h5


"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-5." [PRO:DNx, UniProtKB:Q96GD4]


organism-modification



PR:000035661

aurora kinase B unphosphorylated form (human)

hAURKB/PhosRes-


"An aurora kinase B unphosphorylated form in human." [PMID:22024163, PRO:KER]

Yes

organism-modification



PR:000035663

aurora kinase B phosphorylated 1 (human)

hAURKB/Phos:1


"An aurora kinase B phosphorylated 1 in human. This phosphorylated form is present during prometaphase, metaphase, and loss of tension on kinetochores (taxol). UniProtKB:Q96GD4, Ser-331, MOD:00046." [PMID:17276342, PMID:22024163, PMID:23321637, PRO:CNA, PRO:KER]

Yes

organism-modification



PR:000046026

aurora kinase B phosphorylated 2 (human)

hAURKB/Phos:2


"An aurora kinase B (human) that has been phosphorylated on the residue at the position equivalent to Thr-232 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Thr-232, MOD:00047." [iPTMnet:Q96GD4, PMID:14722118, PMID:18767990]


organism-modification



PR:000046440

aurora kinase B sumoylated 1 (human)

hAURKB/Sumo:1


"An aurora kinase B (human) that has been post-translationally modified to include sumoylated lysine at position 202 of the amino acid sequence represented by UniProtKB:Q96GD4. UniProtKB:Q96GD4, Lys-202, MOD:01149." [PRO:DNx, Reactome:R-HSA-4655414]


organism-modification



PR:000075980

aurora kinase B methylated 1 (human)

hAURKB/Me:1


"An aurora kinase B (human) that has been methylated on the residue at the position equivalent to Cys-170 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Cys-170, MOD:00660." [IEDB_epitope:1023665, PRO:DNx]


organism-modification



PR:000077527

aurora kinase B cysteinylated 1 (human)

hAURKB/Cyst:1


"An aurora kinase B (human) that has been cysteinylated on the residue at the position equivalent to Cys-170 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Cys-170, MOD:00765." [IEDB_epitope:1023664, PRO:DNx]


organism-gene



PR:Q9VKN7

aurora kinase B (fruit fly)

fly-AURKB


"An aurora kinase B that is encoded in the genome of fruit fly." [PANTHER:PTHR24350:SF49, PRO:DNx]


modification



PR:000019090

aurora kinase B, initiator methionine removed form

AURKB/InitMet-


"An aurora kinase B that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000035660

aurora kinase B unphosphorylated form

AURKB/PhosRes-


"An aurora kinase B that lacks phosphorylated residues." [PMID:22024163, PRO:KER]


organism-modification



PR:000035661

aurora kinase B unphosphorylated form (human)

hAURKB/PhosRes-


"An aurora kinase B unphosphorylated form in human." [PMID:22024163, PRO:KER]

Yes

modification



PR:000035662

aurora kinase B phosphorylated 1

AURKB/Phos:1


"An aurora kinase B that has been phosphorylated on a residue equivalent to Ser-331 of the amino acid sequence represented by UniProtKB:Q96GD4. Example: UniProtKB:Q96GD4, Ser-331, MOD:00046." [PMID:17276342, PMID:22024163, PRO:KER]


organism-modification



PR:000035663

aurora kinase B phosphorylated 1 (human)

hAURKB/Phos:1


"An aurora kinase B phosphorylated 1 in human. This phosphorylated form is present during prometaphase, metaphase, and loss of tension on kinetochores (taxol). UniProtKB:Q96GD4, Ser-331, MOD:00046." [PMID:17276342, PMID:22024163, PMID:23321637, PRO:CNA, PRO:KER]

Yes

gene



PR:000004518

aurora kinase C

AURKC


"An aurora kinase that is a translation product of the human AURKC gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:D4AD76

aurora kinase C (rat)

rAURKC


"An aurora kinase C that is encoded in the genome of rat." [OMA:D4AD76, PRO:DNx]


organism-gene



PR:O64629

serine/threonine-protein kinase Aurora-3 (Arabidopsis thaliana)

At-AURKC


"An aurora kinase C that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]


organism-gene



PR:O88445

aurora kinase C (mouse)

mAURKC


"An aurora kinase C that is encoded in the genome of mouse." [OMA:O88445, PRO:DAN]


organism-gene



PR:Q9UQB9

aurora kinase C (human)

hAURKC


"An aurora kinase C that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UQB9]


organism-sequence



PR:Q9UQB9-1

aurora kinase C isoform h1 (human)

hAURKC/iso:h1


"An aurora kinase C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQB9-1." [PRO:DNx, UniProtKB:Q9UQB9]


organism-sequence



PR:Q9UQB9-2

aurora kinase C isoform h2 (human)

hAURKC/iso:h2


"An aurora kinase C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQB9-2." [PRO:DNx, UniProtKB:Q9UQB9]


organism-sequence



PR:Q9UQB9-3

aurora kinase C isoform h3 (human)

hAURKC/iso:h3


"An aurora kinase C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQB9-3." [PRO:DNx, UniProtKB:Q9UQB9]


organism-gene



PR:P38991

aurora kinase (yeast)

yIPL1


"An aurora kinase that is a translation product of the IPL1 gene in yeast." [PRO:DAN, PRO:KER]

Yes

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035661 hAURKB/PhosRes- enablesGO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:22024163
located_inGO:0000776 kinetochore PMID:22024163
PR:000035663 hAURKB/Phos:1
UniProtKB:Q96GD4, Ser-331, MOD:00046
acts_upstream_of_or_withinincreased GO:0007059 chromosome segregation relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
increased GO:0031577 spindle checkpoint signaling relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
increased GO:0051310 metaphase chromosome alignment relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
enablesincreased GO:0004672 protein kinase activity relative to PR:000035661 hAURKB/PhosRes- PMID:17276342; PMID:22024163
GO:0005515 protein binding PMID:22024163
located_inGO:0000776 kinetochore PMID:22024163
PR:O14965 hAURKA enablesGO:0005515 protein binding with PR:Q9H4B4 CNK PMID:15190214
located_inGO:0000922 spindle pole PMID:15190214
GO:0005813 centrosome PMID:15190214
GO:0030496 midbody PMID:15190214
PR:P38991 yIPL1 enablesGO:0004672 protein kinase activity PMID:17504936
PR:Q96GD4 hAURKB acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:12719470
GO:0008608 attachment of spindle microtubules to kinetochore PMID:12719470; PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:12719470
GO:0034501 protein localization to kinetochore PMID:12719470; PMID:17617734; PMID:22732840
NOT GO:0051306 mitotic sister chromatid separation PMID:12719470
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:22732840
GO:0071459 protein localization to chromosome, centromeric region PMID:12719470; PMID:21658950
GO:0140014 mitotic nuclear division PMID:12719470
enablesGO:0004672 protein kinase activity PMID:12719470
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P06493 CDC2 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P68431 H3C1 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q13043 hSTK4 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q15208 hSTK38 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q53HL2 CDCA8 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q71DI3 H3-clustered histone 13 (human) BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
located_inGO:0000776 kinetochore PMID:20624902
GO:0000779 condensed chromosome, centromeric region PMID:12719470; PMID:15917996
GO:0000939 inner kinetochore PMID:15592459
GO:0030496 midbody PMID:15917996
GO:0051233 spindle midzone PMID:15917996