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Protein Ontology report - catenin beta-1 isoform 1 phosphorylated 3
PR:000035771 - http://purl.obolibrary.org/obo/PR_000035771
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035771   
  PRO namecatenin beta-1 isoform 1 phosphorylated 3 
  Synonyms
PRO-Short-label: EXACT:CTNNB1/iso:1/Phos:3
  Definition"A catenin beta-1 isoform 1 that has been phosphorylated on Ser and Thr residues within the GSK3B recognition motif DSGxxS and the third Thr residue and second Ser residue within the adjacent sequence GATTTAPSLS. Apparently phosphorylation is sequential and occurs from C- to N terminus of the sequence. Phosphorylation of these sites target beta catenin-1 for degradation. Example: UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:16199882, PRO:IC] 
  CommentNote: In vivo. 
  PRO Categorymodification 
  ParentPR:000002319 catenin beta-1 isoform 1
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000035771
catenin beta-1 isoform 1 phosphorylated 3
CTNNB1/iso:1/Phos:3
"A catenin beta-1 isoform 1 that has been phosphorylated on Ser and Thr residues within the GSK3B recognition motif DSGxxS and the third Thr residue and second Ser residue within the adjacent sequence GATTTAPSLS. Apparently phosphorylation is sequential and occurs from C- to N terminus of the sequence. Phosphorylation of these sites target beta catenin-1 for degradation. Example: UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:16199882, PRO:IC]

organism-modification


PR:000035772
catenin beta-1 isoform 1 phosphorylated 3 (human)
hCTNNB1/iso:1/Phos:3
"A catenin beta-1 isoform 1 phosphorylated 3 in human. Phosphorylation at Ser-45 is needed for the other sites to be phosphorylated. UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:12000790, PMID:16199882, PRO:IC]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035772 hCTNNB1/iso:1/Phos:3
UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047		 enablesNOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:10074433
NOT GO:0005515 protein binding with PR:Q9UKB1 BTRCP2 PMID:10074433