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Protein Ontology report - IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
PR:000036029 - http://purl.obolibrary.org/obo/PR_000036029
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036029   
  PRO nameIRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex 
  Synonyms
Reactome-displayName: RELATED:activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF3
  Definition"An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated tbk1, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated tbk1." [] 
  CommentRequested by=TLR. 
  PRO Categorycomplex 
  ParentPR:000028699 IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex1                                                  Organism-Complex 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
complex


PR:000036029
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
BTBD7/iso:3
"An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated tbk1, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated tbk1." []

organism-complex


PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
BTBD7/iso:3
"An IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." []
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036030 BTBD7/iso:3 acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enablesGO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_inGO:0010008 endosome membrane Reactome:REACT_27000