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Protein Ontology report - TIRAP:PIP2:activated TLR4 complex
PR:000036078 - http://purl.obolibrary.org/obo/PR_000036078
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036078   
  PRO nameTIRAP:PIP2:activated TLR4 complex 
  Synonyms
Other: EXACT:Mal:activated TLR4 complex | MAL:PIP2:LY96:LPS:TLR4 | MAL:PIP2:MD2:LPS:TLR4
  Definition"A protein-containing complex that is composed of TIRAP (MAL) bound to phosphatidyl inositol 4,5-bisphosphate in complex with the TLR4:MD2:LPS complex." [PMID:12447442, TLR:AMM] 
  CommentRequested by=TLR. 
  PRO Categorycomplex 
  ParentG0032991 protein-containing complex
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex1                                                  Organism-Complex 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
complex



PR:000036078

TIRAP:PIP2:activated TLR4 complex

mTLR4actv


"A protein-containing complex that is composed of TIRAP (MAL) bound to phosphatidyl inositol 4,5-bisphosphate in complex with the TLR4:MD2:LPS complex." [PMID:12447442, TLR:AMM]


organism-complex



PR:000027196

TIRAP:PIP2:activated TLR4 (mouse)

hIRAK4/iso:1/Phos:1


"A TIRAP:PIP2:activated TLR4 complex in mouse in which the TLR4 and LY96 components are N-glycosylated." [PMID:11544529, PMID:12447442, TLR:AMM]

Yes

organism-complex



PR:000027217

pTIRAP:PIP2:activated TLR4 complex (mouse)

mTIRAP/Phos:1


"A TIRAP:PIP2:activated TLR4 complex in mouse in which the TIRAP/MAL component is phosphorylated." [TLR:AMM]


organism-complex



PR:000027218

pTIRAP:PIP2:activated TLR4 complex (human)

mTIRAP/Phos:1


"A TIRAP:PIP2:activated TLR4 complex in human in which the TIRAP/MAL component is phosphorylated." [PMID:12724322, PMID:18070880, TLR:AMM]


organism-complex



PR:000036135

TIRAP:PIP2:activated TLR4 complex (human)

hTPT1/AcPhos:1


"A TIRAP:PIP2:activated TLR4 complex in human in which the TLR4 and LY96 components are N-glycosylated and which also contains CD14." [Reactome:R-HSA-2559411]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027196 hIRAK4/iso:1/Phos:1 acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12447442
PR:000036135 hTPT1/AcPhos:1 acts_upstream_of_or_withinGO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
located_inGO:0005886 plasma membrane Reactome:REACT_152404