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Protein Ontology report - presenilin-2 isoform PS2beta
PR:000036853 - http://purl.obolibrary.org/obo/PR_000036853
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036853   
  PRO namepresenilin-2 isoform PS2beta 
  Synonyms
PRO-Short-label: EXACT:PSEN2/iso:PS2beta
Other: EXACT:PS2beta
  Definition"A presenilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61144-2 or a 1:1 ortholog thereof. This isoform contains N-terminal fragment (NTF) and hydrophilic loop domain, but not C-terminal fragment (CTF)." [PMID:19376115, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000013345 presenilin-2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000036853
presenilin-2 isoform PS2beta
PSEN2/iso:PS2beta
"A presenilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61144-2 or a 1:1 ortholog thereof. This isoform contains N-terminal fragment (NTF) and hydrophilic loop domain, but not C-terminal fragment (CTF)." [PMID:19376115, PRO:CNA]

organism-sequence


PR:000036856
presenilin-2 isoform PS2beta (human)
hPSEN2/iso:PS2beta
"A presenilin-2 isoform PS2beta that is encoded in the genome of human." [PMID:19376115, PRO:CNA]

organism-sequence


PR:Q61144-2
presenilin-2 isoform PS2beta (mouse)
mPSEN2/iso:PS2beta
"A presenilin-2 isoform PS2beta that is encoded in the genome of mouse. The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA." [PMID:19376115, PRO:KRC]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q61144-2 mPSEN2/iso:PS2beta
The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA		 acts_upstream_of_or_withinGO:0031333 negative regulation of protein-containing complex assembly MGI_ref:3843380; PMID:19376115
GO:0032091 negative regulation of protein binding MGI_ref:3843380; PMID:19376115
located_inGO:0005783 endoplasmic reticulum MGI_ref:3843380; PMID:19376115