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Protein Ontology report - palmitoylated protein

PR:000037071 - http://purl.obolibrary.org/obo/PR_000037071

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000037071

PRO name

palmitoylated protein

Synonyms

PRO-Short-label:

EXACT:

Prot/PalmRes+

Definition

"A protein that includes at least one palmitoylated residue." [PRO:DAN]

PRO Category

modification

Parent

PR:000000001 protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	4	Organism-Modification	38

Term Hierarchy
Visualization

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OLS:

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Protein Forms

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Category

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?

modification

PR:000037071

palmitoylated protein

Prot/PalmRes+

"A protein that includes at least one palmitoylated residue." [PRO:DAN]

modification

PR:000035639

glutamate receptor-interacting protein 1 isoform 2 palmitoylated 1

GRIP1/iso:2/Palm:1

"A glutamate receptor-interacting protein 1 isoform 2 that has been palmitoylated on a residue equivalent to Cys-11 of the amino acid sequence represented by UniProtKB:Q925T6-2. Example: UniProtKB:Q925T6-2, Cys-11, MOD:00115." [PMID:11335060, PMID:22325201, PRO:HJD]

organism-modification

PR:000035640

glutamate receptor-interacting protein 1 isoform 2 palmitoylated 1 (mouse)

mGRIP1/iso:2/Palm:1

"A glutamate receptor-interacting protein 1 isoform 2 palmitoylated 1 in mouse. UniProtKB:Q925T6-2, Cys-11, MOD:00115." [PMID:11335060, PMID:22325201, PRO:HJD]

Yes

modification

PR:000035695

serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1

AATK/iso:2/Palm:1

"A serine/threonine-protein kinase LMTK1 isoform 2 that has been palmitoylated on the Cys residues in the motif CLCCKK located at the N-terminal region. Example: UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115." [PMID:18691334, PRO:KRC]

organism-modification

PR:000035696

serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 (mouse)

mAATK/iso:2/Palm:1

"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115." [PMID:18691334, PRO:KRC]

Yes

modification

PR:000035697

serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1

AATK/iso:2/PalmPhos:1

"A serine/threonine-protein kinase LMTK1 isoform 2 that has been palmitoylated on the Cys residues in the motif CLCCKK located at the N-terminal region, and phosphorylated on two Tyr in Src family tyrosine kinases (SFKs) sites. Palmitoylation is necessary for the phosphorylation to occur. Example: UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115|Tyr-25/Tyr-46, MOD:00048." [PMID:18691334, PRO:CNA]

organism-modification

PR:000035698

serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 (mouse)

mAATK/iso:2/PalmPhos:1

"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115|Tyr-25/Tyr-46, MOD:00048." [PMID:18691334, PRO:KRC]

organism-modification

PR:000037269

sonic hedgehog protein N-product dually lipidated 1 (mouse)

mSHH/Clv:Nter/2*Lipid:1

"A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]

Yes

organism-modification

PR:000037274

sonic hedgehog protein N-product dually lipidated 1 (human)

hSHH/Clv:Nter/2*Lipid:1

"A sonic hedgehog protein N-product in human that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q15465, 24-197, Cys-24, MOD:00069|Gly-197, MOD:00314." [PMID:9593755, PRO:CNA]

organism-modification

PR:000046216

phospholipid-transporting ATPase ABCA1 palmitoylated 1 (human)

hABCA1/Palm:1

"A phospholipid-transporting ATPase ABCA1 (human) that has been post-translationally modified to include palmitoylated residue at positions 3, 23, 1110 and 1111 of the amino acid sequence represented by UniProtKB:O95477. UniProtKB:O95477, Cys-3/Cys-23/Cys-1110/Cys-1111, MOD:00115." [PRO:DNx, Reactome:R-HSA-5682085, Reactome:R-HSA-5682091]

organism-modification

PR:000046636

platelet glycoprotein 4, initiator methionine removed palmitoylated 1 (human)

hCD36/InitMet-/Palm:1

"A platelet glycoprotein 4 (human) that has had the initiator methionine removed and has been post-translationally modified to include palmitoylated residue at positions 3, 7, 464 and 466 of the amino acid sequence represented by UniProtKB:P16671. UniProtKB:P16671, 2-472, Cys-3/Cys-7/Cys-464/Cys-466, MOD:00115." [PRO:DNx, Reactome:R-HSA-2239449, Reactome:R-HSA-51645]

organism-modification

PR:000046726

cytoskeleton-associated protein 4 palmitoylated 1 (human)

hCKAP4/Palm:1

"A cytoskeleton-associated protein 4 (human) that has been post-translationally modified to include palmitoylated residue at position 100 of the amino acid sequence represented by UniProtKB:Q07065. UniProtKB:Q07065, Cys-100, MOD:00115." [PRO:DNx, Reactome:R-HSA-5686280, Reactome:R-HSA-5686285]

organism-modification

PR:000047353

tissue factor, signal peptide removed palmitoylated 1 (human)

hF3/SigPep-/Palm:1

"A tissue factor (human) that has had the signal peptide removed and has been post-translationally modified to include palmitoylated residue at position 277 of the amino acid sequence represented by UniProtKB:P13726. UniProtKB:P13726, 33-295, Cys-277, MOD:00115." [PRO:DNx, Reactome:R-HSA-140704]

organism-modification

PR:000049224

phosphatidylcholine:ceramide cholinephosphotransferase 2 palmitoylated 1 (human)

hSGMS2/Palm:1

"A phosphatidylcholine:ceramide cholinephosphotransferase 2 (human) that has been post-translationally modified to include palmitoylated residue at positions 343 and 348 of the amino acid sequence represented by UniProtKB:Q8NHU3. UniProtKB:Q8NHU3, Cys-343/Cys-348, MOD:00115." [PRO:DNx, Reactome:R-HSA-429775]

organism-modification

PR:000049303

synaptosomal-associated protein 25 palmitoylated 1 (human)

hSNAP25/Palm:1

"A synaptosomal-associated protein 25 (human) that has been post-translationally modified to include palmitoylated residue at positions 85, 88, 90 and 92 of the amino acid sequence represented by UniProtKB:P60880. UniProtKB:P60880, Cys-85/Cys-88/Cys-90/Cys-92, MOD:00115." [PRO:DNx, Reactome:R-HSA-2029017]

organism-modification

PR:000049785

photoreceptor disk component PRCD palmitoylated 1 (mouse)

mPRCD/Palm:1

"A photoreceptor disk component PRCD (mouse) that has been post-translationally modified to include S-palmitoylation at Cys-2 of the amino acid sequence represented by UniProtKB:Q00LT2. UniProtKB:Q00LT2, Cys-2, MOD:00115." [PMID:27613864, PRO:HJD]

organism-modification

PR:000049787

photoreceptor disk component PRCD palmitoylated 1 (human)

hPRCD/Palm:1

"A photoreceptor disk component PRCD (human) that has been post-translationally modified to include S-palmitoylation at Cys-2 of the amino acid sequence represented by UniProtKB:Q00LT1. UniProtKB:Q00LT1, Cys-2, MOD:00115." [PMID:27613864, PRO:HJD]

organism-modification

PR:000060241

nuclear fusion protein tht1 palmitoylated 1 (Schizosaccharomyces pombe)

Spom-tht1/Palm:1

"A nuclear fusion protein tht1 (Schizosaccharomyces pombe) that has been palmitoylated at positions equivalent to Cys-65 and Cys-78 of the amino acid sequence represented by UniProtKB:Q09684. Example: UniProtKB:Q09684, Cys-65/Cys-78, MOD:00115." [PMID:36650056, PomBase:MLR, PRO:DAN]

organism-modification

PR:000060707

tyrosine-protein kinase Fyn, initiator methionine removed myristoylated and palmitoylated 1 (human)

hFYN/InitMet-/MyrPalm:1

"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and palmitoylated on the residues at the positions equivalent to Cys-3 and Cys-6 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Cys-3/Cys-6, MOD:00115." [PRO:DNx, Reactome:R-HSA-9606873]

organism-modification

PR:000060852

retinoid isomerohydrolase, initiator methionine removed palmitoylated 1 (human)

hRPE65/InitMet-/Palm:1

"A retinoid isomerohydrolase (human) that has had the initiator methionine removed and that has been palmitoylated on the residue at the position equivalent to Cys-112 of the amino acid sequence represented by UniProtKB:Q16518. UniProtKB:Q16518, 2-533, Cys-112, MOD:00069." [PRO:DNx, Reactome:R-HSA-74853]

organism-modification

PR:000061165

neuromodulin palmitoylated 1 (human)

hGAP43/Palm:1

"A neuromodulin (human) that has been palmitoylated on the residues at the positions equivalent to Cys-3 and Cys-4 of the amino acid sequence represented by UniProtKB:P17677-1. Example: UniProtKB:P17677-1, Cys-3/Cys-4, MOD:00115." [PRO:DNx, Reactome:R-HSA-8933482]

organism-modification

PR:000061250

estrogen receptor isoform h3 palmitoylated 1 (human)

hESR1/iso:h3/Palm:1

"An estrogen receptor isoform h3 (human) that has been palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-3. UniProtKB:P03372-3, Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020991, Reactome:R-HSA-9021055]

organism-modification

PR:000061468

asialoglycoprotein receptor 1 palmitoylated 1 (human)

hASGR1/Palm:1

"An asialoglycoprotein receptor 1 (human) that has been palmitoylated on the residue at the position equivalent to Cys-36 of the amino acid sequence represented by UniProtKB:P07306-1. Example: UniProtKB:P07306-1, Cys-36, MOD:00069." [PRO:DNx, Reactome:R-HSA-8855714]

organism-modification

PR:000061586

nitric oxide synthase 3, initiator methionine removed myristoylated and palmitoylated 1 (human)

hNOS3/InitMet-/MyrPalm:1

"A nitric oxide synthase 3 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and palmitoylated on the residues at the positions equivalent to Cys-15 and Cys-26 of the amino acid sequence represented by UniProtKB:P29474-1. Example: UniProtKB:P29474-1, 2-1203, Gly-2, MOD:00068|Cys-15/Cys-26, MOD:00115." [PRO:DNx, Reactome:R-HSA-203769, Reactome:R-HSA-534993, Reactome:R-HSA-535007]

organism-modification

PR:000061694

estrogen receptor palmitoylated 1 (human)

hESR1/Palm:1

"An estrogen receptor (human) that has been palmitoylated on the residue at the position equivalent to Cys-447 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Cys-447, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020974, Reactome:R-HSA-9021057]

organism-modification

PR:000061959

blood group Rh(D) polypeptide, initiator methionine removed S-palmitoylcysteine form (human)

hRHD/InitMet-/SPalmCys+

"A blood group Rh(D) polypeptide (human) that has had the initiator methionine removed and that includes at least one S-palmitoylated residue. Example: UniProtKB:Q02161-1, 2-417, MOD:00115." [PRO:DNx, Reactome:R-HSA-5216038]

organism-modification

PR:000062632

nitric oxide synthase 3, initiator methionine removed myristoylated, palmitoylated, and phosphorylated 1 (human)

hNOS3/InitMet-/MyrPalmPhos:1

"A nitric oxide synthase 3 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2, palmitoylated on the residues at the positions equivalent to Cys-15 and Cys-26, and phosphorylated on the residue at the position equivalent to Ser-1177 of the amino acid sequence represented by UniProtKB:P29474-1. Example: UniProtKB:P29474-1, 2-1203, Gly-2, MOD:00068|Cys-15/Cys-26, MOD:00115|Ser-1177, MOD:00046." [PRO:DNx, Reactome:R-HSA-202139]

organism-modification

PR:000062642

estrogen receptor beta omega-methylated and palmitoylated 1 (human)

hESR2/Me1oPalm:1

"An estrogen receptor beta (human) that has been palmitoylated on the residue at the position equivalent to Cys-399 of the amino acid sequence represented by UniProtKB:Q92731-1 and that includes at least one omega-methyl-L-arginine. Example: UniProtKB:Q92731-1, Cys-399, MOD:00115|MOD:00078." [PRO:DNx, Reactome:R-HSA-9637787]

organism-modification

PR:000062654

estrogen receptor isoform h3 omega-methylated and palmitoylated 1 (human)

hESR1/iso:h3/Me1oPalm:1

"An estrogen receptor isoform h3 (human) that has been omega-methylated on the residue at the position equivalent to Arg-87 and palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-3. UniProtKB:P03372-3, Arg-87, MOD:00078|Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9637790]

organism-modification

PR:000062893

asialoglycoprotein receptor 2 palmitoylated 1 (human)

hASGR2/Palm:1

"An asialoglycoprotein receptor 2 (human) that has been palmitoylated on the residues at the positions equivalent to Cys-54 and Cys-58 of the amino acid sequence represented by UniProtKB:P07307-1. Example: UniProtKB:P07307-1, Cys-54/Cys-58, MOD:00069." [PRO:DNx, Reactome:R-HSA-8855706]

organism-modification

PR:000063016

estrogen receptor isoform h4 omega-methylated and palmitoylated 1 (human)

hESR1/iso:h4/Me1oPalm:1

"An estrogen receptor isoform h4 (human) that has been omega-methylated on the residue at the position equivalent to Arg-87 and palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-4. UniProtKB:P03372-4, Arg-87, MOD:00078|Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9637786]

organism-modification

PR:000063476

tyrosine-protein kinase Lyn, initiator methionine removed myristoylated and palmitoylated 1 (human)

hLYN/InitMet-/MyrPalm:1

"A tyrosine-protein kinase Lyn (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and palmitoylated on the residue at the position equivalent to Cys-3 of the amino acid sequence represented by UniProtKB:P07948-1. Example: UniProtKB:P07948-1, 2-512, Gly-2, MOD:00068|Cys-3, MOD:00115." [PRO:DNx, Reactome:R-HSA-9606875, Reactome:R-HSA-9705728, Reactome:R-HSA-9707903]

organism-modification

PR:000063648

estrogen receptor omega-methylated and palmitoylated 1 (human)

hESR1/Me1oPalm:1

"An estrogen receptor (human) that has been omega-methylated on the residue at the position equivalent to Arg-260 and palmitoylated on the residue at the position equivalent to Cys-447 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Arg-260, MOD:00078|Cys-447, MOD:00115." [PRO:DNx, Reactome:R-HSA-9637788]

organism-modification

PR:000064174

estrogen receptor beta palmitoylated 1 (human)

hESR2/Palm:1

"An estrogen receptor beta (human) that has been palmitoylated on the residue at the position equivalent to Cys-399 of the amino acid sequence represented by UniProtKB:Q92731-1. Example: UniProtKB:Q92731-1, Cys-399, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020979, Reactome:R-HSA-9021059]

organism-modification

PR:000064345

estrogen receptor isoform h4 palmitoylated 1 (human)

hESR1/iso:h4/Palm:1

"An estrogen receptor isoform h4 (human) that has been palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-4. UniProtKB:P03372-4, Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020988, Reactome:R-HSA-9021053]

organism-modification

PR:000067190

phospholipid-transporting ATPase ABCA1 palmitoylated and phosphorylated 1 (human)

hABCA1/PalmPhos:1

"A phospholipid-transporting ATPase ABCA1 (human) that has been palmitoylated on the residues at the positions equivalent to Cys-3, Cys-23, Cys-1110 and Cys-1111, and phosphorylated on the residues at the positions equivalent to Ser-1042 and Ser-2054 of the amino acid sequence represented by UniProtKB:O95477. UniProtKB:O95477, Cys-3/Cys-23/Cys-1110/Cys-1111, MOD:00115|Ser-1042/Ser-2054, MOD:00046." [PRO:DNx, Reactome:R-HSA-5682069]

organism-modification

PR:000067446

GTPase NRas, mature palmitoylated and prenylated-cysteine methyl ester-containing 1 (human)

hNRAS/mature/IpCysEstPalm:1

"A GTPase NRas (human) that has had the propeptide removed, and that has been palmitoylated on the residue at the position equivalent to Cys-181 and prenylated-cysteine methyl ester-containing on the residue at the position equivalent to Cys-186 of the amino acid sequence represented by UniProtKB:P01111. UniProtKB:P01111, 1-186, Cys-181, MOD:00115|Cys-186, MOD:01116." [PRO:DNx, Reactome:R-HSA-9647906, Reactome:R-HSA-9647910]

organism-modification

PR:000073706

apolipoprotein B-100 palmitoylated 1 (human)

hAPOB/Palm:1

"An apolipoprotein B-100 (human) that has been palmitoylated on the residue at the position equivalent to Ser-731 of the amino acid sequence represented by UniProtKB:P04114. UniProtKB:P04114, Ser-731, MOD:00089." [IEDB_epitope:1860499, IEDB_epitope:1860500, IEDB_epitope:1860501, PRO:DNx]

organism-modification

PR:000076058

aldehyde dehydrogenase family 3 member B1, mature palmitoylated and prenylated 1 (human)

hALDH3B1/mature/IpPalm:1

"An aldehyde dehydrogenase family 3 member B1 (human) that has had the propeptide removed, and that has been palmitoylated on the residue at the position equivalent to Cys-463 and prenylated on the residue at the position equivalent to Cys-465 of the amino acid sequence represented by UniProtKB:P43353-1. Example: UniProtKB:P43353-1, 1-465, Cys-463, MOD:00115|Cys-465, MOD:00113." [PRO:DNx, Reactome:R-HSA-5696096]

organism-modification

PR:000078134

Ras-related C3 botulinum toxin substrate 1, mature palmitoylated and prenylated 1 (human)

hRAC1/mature/IpPalm:1

"A Ras-related C3 botulinum toxin substrate 1 (human) that has had the propeptide removed, and that has been palmitoylated on the residue at the position equivalent to Cys-178 and prenylated on the residue at the position equivalent to Cys-189 of the amino acid sequence represented by UniProtKB:P63000. UniProtKB:P63000, 1-189, Cys-178, MOD:00115|Cys-189, MOD:00113." [PRO:DNx, Reactome:R-HSA-2316446]

organism-modification

PR:000085916

nitric oxide synthase 3, initiator methionine removed myristoylated, palmitoylated, and phosphorylated 2 (human)

hNOS3/InitMet-/MyrPalmPhos:2

"A nitric oxide synthase 3 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2, palmitoylated on the residues at the positions equivalent to Cys-15 and Cys-26, and phosphorylated on the residues at the positions equivalent to Ser-1177 and Ser-1179 of the amino acid sequence represented by UniProtKB:P29474-1. Example: UniProtKB:P29474-1, 2-1203, Gly-2, MOD:00068|Cys-15/Cys-26, MOD:00115|Ser-1177/Ser-1179, MOD:00046." [PRO:DNx, Reactome:R-HSA-9860783]

organism-modification

PR:000085948

nitric oxide synthase 3, initiator methionine removed myristoylated, palmitoylated, and phosphorylated 3 (human)

hNOS3/InitMet-/MyrPalmPhos:3

"A nitric oxide synthase 3 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2, palmitoylated on the residues at the positions equivalent to Cys-15 and Cys-26, and phosphorylated on the residue at the position equivalent to Ser-633 of the amino acid sequence represented by UniProtKB:P29474-1. Example: UniProtKB:P29474-1, 2-1203, Gly-2, MOD:00068|Cys-15/Cys-26, MOD:00115|Ser-633, MOD:00046." [PRO:DNx, Reactome:R-HSA-9861341]

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Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000035640 mGRIP1/iso:2/Palm:1 UniProtKB:Q925T6-2, Cys-11, MOD:00115	located_in	GO:0055037 recycling endosome	MGI_ref:5315188; PMID:22325201
PR:000035696 mAATK/iso:2/Palm:1 UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115	enables	GO:0005515 protein binding with PR:P12931 hSRC	MGI_ref:3820458; PMID:18691334
	located_in	GO:0055037 recycling endosome	MGI_ref:3820458; PMID:18691334
PR:000037269 mSHH/Clv:Nter/2*Lipid:1 UniProtKB:Q62226, 25-198, Cys-25, MOD:00069\|Gly-198, MOD:00314	acts_upstream_of_or_within	GO:0007224 smoothened signaling pathway	MGI_ref:3039193; PMID:15075292
		GO:0009952 anterior/posterior pattern specification	MGI_ref:2135419; PMID:11389830
		GO:0030326 embryonic limb morphogenesis	MGI_ref:2135419; PMID:11389830
		GO:0042733 embryonic digit morphogenesis	MGI_ref:3039193; PMID:15075292