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Protein Ontology report - pTIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000037448 - http://purl.obolibrary.org/obo/PR_000037448        Annotations       Ontology Information Show OBO stanza / PAF / GPI   PRO ID PR:000037448      PRO name pTIRAP:PIP2:BTK:activated TLR4 complex (human)    Synonyms Other: EXACT: p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4 (human) | p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (human) | p4Y-MAL:PIP2:BTK:activated TLR4 (human)   Definition "A TIRAP:PIP2:BTK:activated TLR4 complex in human that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [PMID:12888566, Reactome:R-HSA-2201325]    Comment Kinase=("TIRAP:PIP2:BTK:activated TLR4 complex (human)"; PR:000037447).    PRO Category organism-complex    Parent PR:000037472 TIRAP:PIP2:BTK:activated TLR4 complex   Taxon NCBITaxon:9606 Homo sapiens   Term Hierarchy   Visualization DAG: OLS: Back to top Functional Annotation (PRO-centric view) Switch to GO Centric View    PRO Term GO Annotation Evidence PR:000037448 FGF14/iso:3 TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282 GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282 located_in GO:0005886 plasma membrane Reactome:REACT_125282