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PRO ID
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| PRO name | pTIRAP:PIP2:BTK:activated TLR4 complex (mouse) |
| Synonyms | | Other: | EXACT: | p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (mouse) | p4Y-MAL:PIP2:BTK:activated TLR4 (mouse) | | RELATED: | p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4 | |
| Definition | "A TIRAP:PIP2:BTK:activated TLR4 complex in mouse that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [TLR:AMM] |
| Comment | Evidence=(ECO:0000088, based on PR:000037448). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial transfer of LPS. |
| PRO Category | organism-complex |
| Parent | PR:000037472 TIRAP:PIP2:BTK:activated TLR4 complex
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| Taxon | NCBITaxon:10090 Mus musculus |
Term Hierarchy
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