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Protein Ontology report - roundabout homolog 3 isoform ROBO3A.1
PR:000037773 - http://purl.obolibrary.org/obo/PR_000037773
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000037773   
  PRO nameroundabout homolog 3 isoform ROBO3A.1 
  Synonyms
PRO-Short-label: EXACT:ROBO3/iso:ROBO3A.1
Other: EXACT:Robo3A.1
  Definition"A roundabout homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96MS0-1 or a 1:1 ortholog thereof. Isoforms ROBO3A have a longer N-terminal sequence than isoforms ROBO3B. Isoforms ROBO3.1 have a C-terminal sequence highly enriched in arginine/serine dipeptide repeats." [PMID:15105459, PMID:16226035, PMID:18466743, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000014153 roundabout homolog 3
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000037773
roundabout homolog 3 isoform ROBO3A.1
ROBO3/iso:ROBO3A.1
"A roundabout homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96MS0-1 or a 1:1 ortholog thereof. Isoforms ROBO3A have a longer N-terminal sequence than isoforms ROBO3B. Isoforms ROBO3.1 have a C-terminal sequence highly enriched in arginine/serine dipeptide repeats." [PMID:15105459, PMID:16226035, PMID:18466743, PRO:CNA]

organism-sequence


PR:D3Z4M6
roundabout homolog 3 isoform ROBO3A.1 (mouse)
mROBO3/iso:ROBO3A1
"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of mouse. This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16226035, PRO:KRC, UniProtKB:D3Z4M6]
Yes
organism-sequence


PR:Q96MS0-1
roundabout homolog 3 isoform ROBO3A.1 (human)
hROBO3/iso:ROBO3A.1
"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of human." [PMID:15105459, PRO:CNA, UniProtKB:Q96MS0]

organism-modification


PR:000060958
roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)
hROBO3/iso:ROBO3A.1/SigPep-
"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed. UniProtKB:Q96MS0-1, 21-1386." [PRO:DNx, Reactome:R-HSA-426410]

organism-modification


PR:000061592
roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)
hROBO3/iso:ROBO3A.1/SigPep-/Phos:1
"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Ser-1330 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Ser-1330, MOD:00046." [PRO:DNx, Reactome:R-HSA-9010775]

organism-modification


PR:000062739
roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)
hROBO3/iso:ROBO3A.1/SigPep-/Phos:2
"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-1019 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Tyr-1019, MOD:00048." [PRO:DNx, Reactome:R-HSA-9011239]

organism-modification


PR:000064762
roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)
hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+
"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]

organism-modification


PR:000064762
roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)
hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+
"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:D3Z4M6 mROBO3/iso:ROBO3A1
This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats		 acts_upstream_of_or_withinGO:0016199 axon midline choice point recognition MGI_ref:3834283; PMID:18466743
GO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
GO:0071679 commissural neuron axon guidance MGI_ref:3834283; PMID:18466743