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Protein Ontology report - protein kinase C beta type isoform 2
PR:000038683 - http://purl.obolibrary.org/obo/PR_000038683
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000038683   
  PRO nameprotein kinase C beta type isoform 2 
  Synonyms
PRO-Short-label: EXACT:PRKCB/iso:2
  Definition"A protein kinase C beta type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05771-2 or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorysequence 
  ParentPR:000003059 protein kinase C beta type
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000038683 protein kinase C beta type isoform 2
PRKCB/iso:2

organism-sequence


PR:P05771-2 protein kinase C beta type isoform Beta-II (human)
hPRKCB/iso:Beta-II
Yes
organism-modification


PR:000049853 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)
hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification


PR:000049854 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)
hPRKCB/iso:Beta-II/InitMet-/UnPhos:1

organism-modification


PR:000049855 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)
hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification


PR:000049856 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2

organism-sequence


PR:P68404-2 protein kinase C beta type isoform Beta-II (mouse)
mPRKCB/iso:Beta-II

organism-modification


PR:000049876 protein kinase C beta type isoform Beta-II phosphorylated 1 (mouse)
mPRKCB/iso:Beta-II/Phos:1

organism-modification


PR:000049877 protein kinase C beta type isoform Beta-II phosphorylated 2 (mouse)
mPRKCB/iso:Beta-II/Phos:2

organism-modification


PR:000049878 protein kinase C beta type isoform Beta-II phosphorylated 3 (mouse)
mPRKCB/iso:Beta-II/Phos:3

organism-modification


PR:000049879 protein kinase C beta type isoform Beta-II phosphorylated 4 (mouse)
mPRKCB/iso:Beta-II/Phos:4

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1
UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047		 enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000049854 hPRKCB/iso:Beta-II/InitMet-/UnPhos:1 PMID:8749392
located_inGO:0005737 cytoplasm PMID:9756933
GO:0005886 plasma membrane PMID:9756933
PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046		 acts_upstream_of_or_withinincreased GO:0006468 protein phosphorylation relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392
enablesincreased GO:0001786 phosphatidylserine binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
increased GO:0005509 calcium ion binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
located_inincreased GO:0005737 cytoplasm relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933
PR:P05771-2 hPRKCB/iso:Beta-II acts_upstream_of_or_withinGO:0001666 response to hypoxia MGI_ref:3847400; PMID:18323529
located_inGO:0016020 membrane MGI_ref:3847400; PMID:18323529