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Protein Ontology report - protein kinase C beta type isoform 2
PR:000038683 - http://purl.obolibrary.org/obo/PR_000038683
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000038683   
  PRO nameprotein kinase C beta type isoform 2 
  Synonyms
PRO-Short-label: EXACT:PRKCB/iso:2
  Definition"A protein kinase C beta type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05771-2 or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorysequence 
  ParentPR:000003059 protein kinase C beta type
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000038683

protein kinase C beta type isoform 2

PRKCB/iso:2


"A protein kinase C beta type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05771-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P05771-2

protein kinase C beta type isoform Beta-II (human)

hPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


organism-sequence



PR:P68404-2

protein kinase C beta type isoform Beta-II (mouse)

mPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000049876

protein kinase C beta type isoform Beta-II phosphorylated 1 (mouse)

mPRKCB/iso:Beta-II/Phos:1


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at position Thr-641. UniProtKB:P68404-2, Thr-641, MOD:00047." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049877

protein kinase C beta type isoform Beta-II phosphorylated 2 (mouse)

mPRKCB/iso:Beta-II/Phos:2


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-654 and Ser-660. UniProtKB:P68404-2, Ser-654/Ser-660, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049878

protein kinase C beta type isoform Beta-II phosphorylated 3 (mouse)

mPRKCB/iso:Beta-II/Phos:3


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-660 and Ser-664. UniProtKB:P68404-2, Ser-660/Ser-664, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049879

protein kinase C beta type isoform Beta-II phosphorylated 4 (mouse)

mPRKCB/iso:Beta-II/Phos:4


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-660 and Ser-673. UniProtKB:P68404-2, Ser-660/Ser-673, MOD:00046." [PMID:21183079, PRO:HJD]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1
UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000049854 hPRKCB/iso:Beta-II/InitMet-/UnPhos:1 PMID:8749392
located_inGO:0005737 cytoplasm PMID:9756933
GO:0005886 plasma membrane PMID:9756933
PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
acts_upstream_of_or_withinincreased GO:0006468 protein phosphorylation relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392
enablesincreased GO:0001786 phosphatidylserine binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
increased GO:0005509 calcium ion binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
located_inincreased GO:0005737 cytoplasm relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933
PR:P05771-2 hPRKCB/iso:Beta-II acts_upstream_of_or_withinGO:0001666 response to hypoxia MGI_ref:3847400; PMID:18323529
located_inGO:0016020 membrane MGI_ref:3847400; PMID:18323529