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Protein Ontology report - cathepsin-like protease
PR:000040662 - http://purl.obolibrary.org/obo/PR_000040662
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000040662   
  PRO namecathepsin-like protease 
  Synonyms
PRO-Short-label: EXACT:fam:CTS
Other: NARROW:cathepsin
  Definition"A protein that is a translation product of some metazoan gene that encodes a signal peptide followed by a single Cathepsin propeptide inhibitor domain (Pfam:PF08246) followed by a single Papain family cysteine protease (Pfam:PF00112) domain at the C terminus." [PRO:DAN] 
  PRO Categoryfamily 
  ParentPR:000036194 eukaryotic protein
  TaxonNCBITaxon:33208 Metazoa
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene18                                                  Organism-Gene 60                                        
         Sequence12                                                  Organism-Sequence 32                                        
         Modification22                                                  Organism-Modification 42                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000040662 cathepsin-like protease
fam:CTS

gene


PR:000001850 cathepsin K
CTSK

organism-gene


PR:O35186 cathepsin K (rat)
rCTSK

organism-sequence


PR:O35186-1 cathepsin K isoform 1 (rat)
rCTSK/iso:1

organism-gene


PR:P43235 cathepsin K (human)
hCTSK

organism-sequence


PR:P43235-1 cathepsin K isoform 1 (human)
hCTSK/iso:1

organism-modification


PR:000075977 cathepsin K, mature form (human)
hCTSK/mature

organism-gene


PR:P43236 cathepsin K (rabbit)
rabbit-CTSK

organism-gene


PR:P55097 cathepsin K (mouse)
mCTSK

organism-sequence


PR:P55097-1 cathepsin K isoform 1 (mouse)
mCTSK/iso:1

organism-gene


PR:Q3ZKN1 cathepsin K (dog)
dog-CTSK

organism-gene


PR:Q9STL4 KDEL-tailed cysteine endopeptidase CEP2 (Arabidopsis thaliana)
At-CTSK

sequence


PR:000039460 cathepsin K isoform 1
CTSK/iso:1

organism-sequence


PR:O35186-1 cathepsin K isoform 1 (rat)
rCTSK/iso:1

organism-sequence


PR:P43235-1 cathepsin K isoform 1 (human)
hCTSK/iso:1

organism-sequence


PR:P55097-1 cathepsin K isoform 1 (mouse)
mCTSK/iso:1

modification


PR:000018547 cathepsin K proteolytic cleavage product
CTSK/ClvPrd

gene


PR:000006023 cathepsin B
CTSB

organism-gene


PR:P00787 cathepsin B (rat)
rCTSB

organism-gene


PR:P07688 cathepsin B (cow)
cow-CTSB

organism-gene


PR:P07858 cathepsin B (human)
hCTSB

organism-sequence


PR:P07858-1 cathepsin B isoform 1 (human)
hCTSB/iso:1

organism-modification


PR:000065779 cathepsin B deaminated 1 (human)
hCTSB/Deam:1

organism-modification


PR:000069475 cathepsin B cysteinylated 1 (human)
hCTSB/Cyst:1

organism-gene


PR:P10605 cathepsin B (mouse)
mCTSB

organism-sequence


PR:P10605-1 cathepsin B isoform 1 (mouse)
mCTSB/iso:1

organism-gene


PR:Q54QD9 cathepsin B (Dictyostelium discoideum)
Dicty-CTSB

organism-gene


PR:Q93VC9 cathepsin B-like protease 2 (Arabidopsis thaliana)
At-CTSB

organism-gene


PR:Q9VY87 cathepsin B1, isoform A (fruit fly)
fly-CTSB

sequence


PR:000038720 cathepsin B isoform 1
CTSB/iso:1

organism-sequence


PR:P07858-1 cathepsin B isoform 1 (human)
hCTSB/iso:1

organism-sequence


PR:P10605-1 cathepsin B isoform 1 (mouse)
mCTSB/iso:1

modification


PR:000019555 cathepsin B proteolytic cleavage product
CTSB/ClvPrd

gene


PR:000006025 cathepsin D
CTSD

organism-gene


PR:O76856 cathepsin D (Dictyostelium discoideum)
Dicty-CTSD

organism-gene


PR:P07339 cathepsin D (human)
hCTSD

organism-modification


PR:000053727 cathepsin D O-glycosylated 1 (human)
hCTSD/OGlyco:1

organism-modification


PR:000065667 cathepsin D glutathionylated 1 (human)
hCTSD/SGlt:1

organism-modification


PR:000074474 cathepsin D cysteinylated 1 (human)
hCTSD/Cyst:1

organism-modification


PR:000076876 cathepsin D cysteinylated 2 (human)
hCTSD/Cyst:2

organism-modification


PR:000079343 cathepsin D deaminated 1 (human)
hCTSD/Deam:1

organism-modification


PR:000085149 cathepsin D cysteinylated 3 (human)
hCTSD/Cyst:3

organism-gene


PR:P18242 cathepsin D (mouse)
mCTSD

organism-gene


PR:P24268 cathepsin D (rat)
rCTSD

organism-modification


PR:000058851 cathepsin D N-glycosylated 1 (rat)
rCTSD/NGlyco:1

organism-modification


PR:000058852 cathepsin D N-glycosylated 2 (rat)
rCTSD/NGlyco:2

organism-modification


PR:000058853 cathepsin D N-glycosylated 3 (rat)
rCTSD/NGlyco:3

organism-modification


PR:000058854 cathepsin D N-glycosylated 4 (rat)
rCTSD/NGlyco:4

organism-modification


PR:000058855 cathepsin D N-glycosylated 5 (rat)
rCTSD/NGlyco:5

organism-modification


PR:000058856 cathepsin D N-glycosylated 6 (rat)
rCTSD/NGlyco:6

organism-gene


PR:P32834 aspartic proteinase sxa1 (Schizosaccharomyces pombe 972h-)
Spom972h-CTSD

organism-gene


PR:Q05744 cathepsin D (chicken)
chick-CTSD

organism-gene


PR:Q21966 aspartic protease 4 (worm)
CTSD (worm)

modification


PR:000019560 cathepsin D, signal peptide removed form
CTSD/SigPep-

modification


PR:000019561 cathepsin D proteolytic cleavage product
CTSD/ClvPrd

gene


PR:000006026 cathepsin E
CTSE

organism-gene


PR:P14091 cathepsin E (human)
hCTSE

organism-sequence


PR:P14091-1 cathepsin E isoform h1 (human)
hCTSE/iso:h1

organism-sequence


PR:P14091-2 cathepsin E isoform h2 (human)
hCTSE/iso:h2

organism-sequence


PR:P14091-3 cathepsin E isoform h3 (human)
hCTSE/iso:h3

organism-modification


PR:000083474 cathepsin E phosphorylated 1 (human)
hCTSE/Phos:1

organism-gene


PR:P16228 cathepsin E (rat)
rCTSE

organism-sequence


PR:P16228-1 cathepsin E isoform r1 (rat)
rCTSE/iso:r1

organism-sequence


PR:P16228-2 cathepsin E isoform r2 (rat)
rCTSE/iso:r2

organism-gene


PR:P55956 aspartic protease 3 (worm)
CTSE (worm)

organism-gene


PR:P70269 cathepsin E (mouse)
mCTSE

modification


PR:000019563 cathepsin E, signal peptide removed form
CTSE/SigPep-

modification


PR:000019564 cathepsin E proteolytic cleavage product
CTSE/ClvPrd

gene


PR:000006027 cathepsin F
CTSF

organism-gene


PR:Q8VYS0 probable cysteine protease RD19D (Arabidopsis thaliana)
At-CTSF

organism-gene


PR:Q9R013 cathepsin F (mouse)
mCTSF

organism-gene


PR:Q9UBX1 cathepsin F (human)
hCTSF

organism-modification


PR:000085606 cathepsin F, mature form (human)
hCTSF/mature

organism-gene


PR:Q9VN93 cathepsin F (fruit fly)
fly-CTSF

organism-sequence


PR:Q9VN93-1 cathepsin F isoform A (fruit fly)
fly-CTSF/iso:A

organism-sequence


PR:Q9VN93-2 cathepsin F isoform B (fruit fly)
fly-CTSF/iso:B

modification


PR:000019565 cathepsin F proteolytic cleavage product
CTSF/ClvPrd

gene


PR:000006028 cathepsin G
CTSG

organism-gene


PR:P08311 cathepsin G (human)
hCTSG

organism-modification


PR:000035925 cathepsin G mature form (human)
hCTSG/mature

organism-modification


PR:000076992 cathepsin G deaminated 1 (human)
hCTSG/Deam:1

organism-gene


PR:P17977 cathepsin G (rat)
rCTSG

organism-gene


PR:P28293 cathepsin G (mouse)
mCTSG

modification


PR:000019567 cathepsin G, signal peptide removed form
CTSG/SigPep-

modification


PR:000035924 cathepsin G mature form
CTSG/mature

organism-modification


PR:000035925 cathepsin G mature form (human)
hCTSG/mature

modification


PR:000019568 cathepsin G proteolytic cleavage product
CTSG/ClvPrd

gene


PR:000006029 cathepsin H
CTSH

organism-gene


PR:P00786 pro-cathepsin H (rat)
rCTSH

organism-sequence


PR:P00786-1 pro-cathepsin H isoform 1 (rat)
rCTSH/iso:1

organism-gene


PR:P09668 pro-cathepsin H (human)
hCTSH

organism-modification


PR:000066541 pro-cathepsin H glutathionylated 1 (human)
hCTSH/SGlt:1

organism-modification


PR:000067353 pro-cathepsin H glutathionylated 2 (human)
hCTSH/SGlt:2

organism-modification


PR:000068758 pro-cathepsin H glutathionylated 3 (human)
hCTSH/SGlt:3

organism-modification


PR:000073015 pro-cathepsin H deaminated 1 (human)
hCTSH/Deam:1

organism-gene


PR:P49935 pro-cathepsin H (mouse)
mCTSH

organism-sequence


PR:P49935-1 pro-cathepsin H isoform 1 (mouse)
mCTSH/iso:1

organism-gene


PR:Q8H166 thiol protease aleurain (Arabidopsis thaliana)
At-CTSH

organism-sequence


PR:Q8H166-1 thiol protease aleurain isoform 1 (Arabidopsis thaliana)
At-CTSH/iso:1

sequence


PR:000039616 cathepsin H isoform 1
CTSH/iso:1

organism-sequence


PR:P00786-1 pro-cathepsin H isoform 1 (rat)
rCTSH/iso:1

organism-sequence


PR:P49935-1 pro-cathepsin H isoform 1 (mouse)
mCTSH/iso:1

modification


PR:000019570 cathepsin H, signal peptide removed form
CTSH/SigPep-

modification


PR:000019571 cathepsin H proteolytic cleavage product
CTSH/ClvPrd

gene


PR:000006030 procathepsin L
CTSL

organism-gene


PR:P07711 procathepsin L (human)
hCTSL

organism-sequence


PR:P07711-1 procathepsin L isoform h1 (human)
hCTSL/iso:h1

organism-sequence


PR:P07711-3 procathepsin L isoform h2 (human)
hCTSL/iso:h2

organism-modification


PR:000053979 procathepsin L N-glycosylated 1 (human)
hCTSL/NGlyco:1

organism-modification


PR:000071161 procathepsin L cysteinylated 1 (human)
hCTSL/Cyst:1

modification


PR:000019573 procathepsin L, signal peptide removed form
CTSL/SigPep-

modification


PR:000019574 procathepsin L proteolytic cleavage product
CTSL/ClvPrd

gene


PR:000006031 cathepsin L2
CTSV

organism-gene


PR:O60911 cathepsin L2 (human)
hCTSV

organism-modification


PR:000066151 cathepsin L2 cysteinylated 1 (human)
hCTSV/Cyst:1

organism-modification


PR:000066514 cathepsin L2, mature form (human)
hCTSV/mature

organism-gene


PR:P25975 procathepsin L (cow)
cow-CTSV

modification


PR:000019575 cathepsin L2 proteolytic cleavage product
CTSL2/ClvPrd

gene


PR:000006032 cathepsin O
CTSO

organism-gene


PR:P43234 cathepsin O (human)
hCTSO

organism-modification


PR:000075968 cathepsin O, mature form (human)
hCTSO/mature

organism-gene


PR:Q8BM88 cathepsin O (mouse)
mCTSO

modification


PR:000019576 cathepsin O proteolytic cleavage product
CTSO/ClvPrd

gene


PR:000006033 cathepsin S
CTSS

organism-gene


PR:O70370 cathepsin S (mouse)
mCTSS

organism-gene


PR:P25326 cathepsin S (cow)
cow-CTSS

organism-gene


PR:P25774 cathepsin S (human)
hCTSS

organism-sequence


PR:P25774-1 cathepsin S isoform h1 (human)
hCTSS/iso:h1

organism-sequence


PR:P25774-2 cathepsin S isoform h2 (human)
hCTSS/iso:h2

organism-modification


PR:000065220 cathepsin S methylated 1 (human)
hCTSS/Me:1

organism-modification


PR:000066825 cathepsin S deaminated 1 (human)
hCTSS/Deam:1

organism-modification


PR:000067604 cathepsin S glutathionylated 1 (human)
hCTSS/SGlt:1

organism-modification


PR:000073880 cathepsin S deaminated 2 (human)
hCTSS/Deam:2

organism-modification


PR:000075024 cathepsin S, mature form (human)
hCTSS/mature

organism-modification


PR:000077000 cathepsin S cysteinylated 1 (human)
hCTSS/Cyst:1

organism-gene


PR:P54640 cysteine proteinase 5 (Dictyostelium discoideum)
Dicty-CTSS

organism-gene


PR:Q02765 cathepsin S (rat)
rCTSS

organism-gene


PR:Q9SUS9 probable cysteine protease RDL5 (Arabidopsis thaliana)
At-CTSS

modification


PR:000019577 cathepsin S proteolytic cleavage product
CTSS/ClvPrd

gene


PR:000006034 cathepsin W
CTSW

organism-gene


PR:P56202 cathepsin W (human)
hCTSW

organism-modification


PR:000077064 cathepsin W, mature form (human)
hCTSW/mature

organism-gene


PR:P56203 cathepsin W (mouse)
mCTSW

modification


PR:000019579 cathepsin W, signal peptide removed form
CTSW/SigPep-

organism-modification


PR:000077064 cathepsin W, mature form (human)
hCTSW/mature

gene


PR:000006035 cathepsin Z
CTSZ

organism-gene


PR:G5EGP8 cathepsin Z-1 (worm)
CTSZ (worm)

organism-sequence


PR:G5EGP8-1 cathepsin Z-1 isoform a (worm)
CTSZ/iso:a (worm)

organism-sequence


PR:G5EGP8-2 cathepsin Z-1 isoform b (worm)
CTSZ/iso:b (worm)

organism-gene


PR:Q9R1T3 cathepsin Z (rat)
rCTSZ

organism-sequence


PR:Q9R1T3-1 cathepsin Z isoform 1 (rat)
rCTSZ/iso:1

organism-gene


PR:Q9UBR2 cathepsin Z (human)
hCTSZ

organism-modification


PR:000067002 cathepsin Z deaminated 1 (human)
hCTSZ/Deam:1

organism-modification


PR:000069819 cathepsin Z deaminated 2 (human)
hCTSZ/Deam:2

organism-modification


PR:000072679 cathepsin Z methylated 1 (human)
hCTSZ/Me:1

organism-modification


PR:000078896 cathepsin Z deaminated 3 (human)
hCTSZ/Deam:3

organism-modification


PR:000085581 cathepsin Z, mature form (human)
hCTSZ/mature

organism-gene


PR:Q9WUU7 cathepsin Z (mouse)
mCTSZ

organism-sequence


PR:Q9WUU7-1 cathepsin Z isoform 1 (mouse)
mCTSZ/iso:1

organism-modification


PR:000070238 cathepsin Z cysteinylated 1 (mouse)
mCTSZ/Cyst:1

sequence


PR:000044078 cathepsin Z isoform 1
CTSZ/iso:1

organism-sequence


PR:Q9R1T3-1 cathepsin Z isoform 1 (rat)
rCTSZ/iso:1

organism-sequence


PR:Q9WUU7-1 cathepsin Z isoform 1 (mouse)
mCTSZ/iso:1

modification


PR:000019580 cathepsin Z proteolytic cleavage product
CTSZ/ClvPrd

gene


PR:000006213 cathepsin J
Ctsj

organism-gene


PR:Q63088 cathepsin J (rat)
rCtsj

organism-gene


PR:Q9R014 cathepsin J (mouse)
mCtsj

modification


PR:000019639 cathepsin J proteolytic cleavage product
Ctsj/ClvPrd

gene


PR:000006214 cathepsin M
Ctsm

organism-gene


PR:Q9JL96 cathepsin M (mouse)
mCtsm

modification


PR:000019640 cathepsin M proteolytic cleavage product
Ctsm/ClvPrd

gene


PR:000006215 cathepsin R
Ctsr

organism-gene


PR:Q9JIA9 cathepsin R (mouse)
mCtsr

gene


PR:000033780 cathepsin 7
Cts7

organism-gene


PR:D3ZZ07 cathepsin 7 (rat)
rCts7

organism-sequence


PR:D3ZZ07-1 cathepsin 7 isoform 1 (rat)
rCts7/iso:1

organism-gene


PR:Q91ZF2 cathepsin 7 (mouse)
mCts7

organism-sequence


PR:Q91ZF2-1 cathepsin 7 isoform 1 (mouse)
mCts7/iso:1

sequence


PR:000042274 cathepsin 7 isoform 1
Cts7/iso:1

organism-sequence


PR:D3ZZ07-1 cathepsin 7 isoform 1 (rat)
rCts7/iso:1

organism-sequence


PR:Q91ZF2-1 cathepsin 7 isoform 1 (mouse)
mCts7/iso:1

gene


PR:000040360 murine-type cathepsin L
murine-Ctsl

organism-gene


PR:P06797 procathepsin L (mouse)
mCtsl

organism-seqgroup


PR:000037136 cathepsin L short form (mouse)
mCtsl/iso:[2/3/4/5/6/7]
Yes
organism-sequence


PR:000037114 procathepsin L isoform 2 (mouse)
mCtsl/iso:2

organism-sequence


PR:000037116 procathepsin L isoform 3 (mouse)
mCtsl/iso:3

organism-sequence


PR:000037118 procathepsin L isoform 4 (mouse)
mCtsl/iso:4

organism-sequence


PR:000037120 procathepsin L isoform 5 (mouse)
mCtsl/iso:5

organism-sequence


PR:000037122 procathepsin L isoform 6 (mouse)
mCtsl/iso:6

organism-sequence


PR:000037124 procathepsin L isoform 7 (mouse)
mCtsl/iso:7

organism-sequence


PR:000037114 procathepsin L isoform 2 (mouse)
mCtsl/iso:2

organism-sequence


PR:000037116 procathepsin L isoform 3 (mouse)
mCtsl/iso:3

organism-sequence


PR:000037118 procathepsin L isoform 4 (mouse)
mCtsl/iso:4

organism-sequence


PR:000037120 procathepsin L isoform 5 (mouse)
mCtsl/iso:5

organism-sequence


PR:000037122 procathepsin L isoform 6 (mouse)
mCtsl/iso:6

organism-sequence


PR:000037124 procathepsin L isoform 7 (mouse)
mCtsl/iso:7

organism-sequence


PR:P06797-1 procathepsin L isoform 1 (mouse)
mCtsl/iso:1
Yes
organism-modification


PR:000037126 procathepsin L isoform 1, signal peptide removed form (mouse)
mCtsl/iso:1/SigPep-

organism-gene


PR:P07154 procathepsin L (rat)
rCtsl

sequence


PR:000037111 murine-type cathepsin L isoform 1
murine-Ctsl/iso:1

organism-sequence


PR:P06797-1 procathepsin L isoform 1 (mouse)
mCtsl/iso:1
Yes
organism-modification


PR:000037126 procathepsin L isoform 1, signal peptide removed form (mouse)
mCtsl/iso:1/SigPep-

modification


PR:000037125 murine-type cathepsin L isoform 1, signal peptide removed form
murine-Ctsl/iso:1/SigPep-

organism-modification


PR:000037126 procathepsin L isoform 1, signal peptide removed form (mouse)
mCtsl/iso:1/SigPep-

sequence


PR:000037113 murine-type cathepsin L isoform 2
murine-Ctsl/iso:2

organism-sequence


PR:000037114 procathepsin L isoform 2 (mouse)
mCtsl/iso:2

sequence


PR:000037115 murine-type cathepsin L isoform 3
murine-Ctsl/iso:3

organism-sequence


PR:000037116 procathepsin L isoform 3 (mouse)
mCtsl/iso:3

sequence


PR:000037117 murine-type cathepsin L isoform 4
murine-Ctsl/iso:4

organism-sequence


PR:000037118 procathepsin L isoform 4 (mouse)
mCtsl/iso:4

sequence


PR:000037119 murine-type cathepsin L isoform 5
murine-Ctsl/iso:5

organism-sequence


PR:000037120 procathepsin L isoform 5 (mouse)
mCtsl/iso:5

sequence


PR:000037121 murine-type cathepsin L isoform 6
murine-Ctsl/iso:6

organism-sequence


PR:000037122 procathepsin L isoform 6 (mouse)
mCtsl/iso:6

sequence


PR:000037123 murine-type cathepsin L isoform 7
murine-Ctsl/iso:7

organism-sequence


PR:000037124 procathepsin L isoform 7 (mouse)
mCtsl/iso:7

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037136 mCtsl/iso:[2/3/4/5/6/7] acts_upstream_of_or_withinGO:0016485 protein processing MGI_ref:3044037; PMID:15099520
GO:0016485 protein processing MGI_ref:3044037; PMID:15099520
GO:0032956 regulation of actin cytoskeleton organization MGI_ref:5297732; PMID:21911934
located_inGO:0005634 nucleus MGI_ref:5297732; PMID:21911934
GO:0005634 nucleus MGI_ref:5297732; PMID:21911934
PR:P06797-1 mCtsl/iso:1 acts_upstream_of_or_withinGO:0016540 protein autoprocessing MGI_ref:5513110; PMID:1482371