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 |
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family
|
|
PR:000044648 |
cyclic nucleotide-regulated channel protein
|
fam:cNuc_chan
|
"A voltage-gated ion channel protein that is involved in intracellular signal transduction, whereby the signal is mediated by a cyclic nucleotide." [GO:0019935, PRO:XQ]
|
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| | | | | | | |
family
|
|
PR:000000673 |
cyclic nucleotide-gated channel alpha subunit
|
CATSPERB
|
"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. In addition, CNG alpha has a carboxy-terminal leucine zipper that seems to be involved in inter-subunit interaction. CNG alpha subunits combine with the beta subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however only alpha subunits are able to homooligomerize and form functional channels." [PMID:12432397, PRO:CNA]
|
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gene
|
|
PR:000000686 |
cyclic nucleotide-gated channel alpha-1
|
CNGA1
|
"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA]
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| | | |
organism-gene
|
|
PR:P29973 |
cyclic nucleotide-gated channel alpha-1 (human)
|
hCNGA1
|
"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29973]
|
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| |
organism-sequence
|
|
PR:000000738 |
cyclic nucleotide-gated channel alpha-1 sequence variant S320F (human)
|
hCNGA1/var:S320F
|
"A cyclic nucleotide-gated channel alpha-1 (human) that has a Phe residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:P29973-1. Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997." [PRO:CNA, PRO:DAN]
|
Yes |
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|
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| | | | | | | | | | |
| |
organism-sequence
|
|
PR:P29973-1 |
cyclic nucleotide-gated channel alpha-1 isoform 1 (human)
|
hCNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000078527 |
cyclic nucleotide-gated channel alpha-1 deaminated 1 (human)
|
hCNGA1/Deam:1
|
"A cyclic nucleotide-gated channel alpha-1 (human) that has been deaminated on the residue at the position equivalent to Asn-159 of the amino acid sequence represented by UniProtKB:P29973. UniProtKB:P29973, Asn-159, MOD:00684." [IEDB_epitope:1327288, PRO:DNx]
|
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| | | |
organism-gene
|
|
PR:P29974 |
cyclic nucleotide-gated channel alpha-1 (mouse)
|
mCNGA1
|
"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of mouse." [OMA:P29974, PRO:DNx]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:P29974-1 |
cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)
|
mCNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q00194 |
cyclic nucleotide-gated channel alpha-1 (cow)
|
cow-CNGA1
|
"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of cow." [OMA:Q00194, PRO:DNx]
|
|
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|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q00194-1 |
cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)
|
cow-CNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036569 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)
|
cow-CNGA1/iso:1/Phos:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]
|
Yes |
|
|
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|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000045379 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)
|
cow-CNGA1/iso:1/Phos:2
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]
|
|
|
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| | | | | | | | | | | | |
organism-modification
|
|
PR:000045381 |
cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)
|
cow-CNGA1/iso:1/UnPhos:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q62927 |
cyclic nucleotide-gated channel alpha-1 (rat)
|
rCNGA1
|
"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of rat." [OMA:Q62927, PRO:DNx]
|
|
|
|
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|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q90980 |
cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken)
|
chick-CNGA1
|
"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of chicken." [OMA:Q90980, PRO:DNx]
|
|
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| | | | | | | | |
| | | |
sequence
|
|
PR:000000737 |
cyclic nucleotide-gated channel alpha-1 isoform 1
|
CNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29973-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:P29973-1 |
cyclic nucleotide-gated channel alpha-1 isoform 1 (human)
|
hCNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:P29974-1 |
cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)
|
mCNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q00194-1 |
cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)
|
cow-CNGA1/iso:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036569 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)
|
cow-CNGA1/iso:1/Phos:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000045379 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)
|
cow-CNGA1/iso:1/Phos:2
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000045381 |
cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)
|
cow-CNGA1/iso:1/UnPhos:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
modification
|
|
PR:000000932 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form
|
CNGA1/iso:1/PhosRes+
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
|
|
|
|
|
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|
| | | | | | | | | | | | |
modification
|
|
PR:000000981 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1
|
CNGA1/iso:1/Phos:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB). Example: UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825]
|
|
|
|
|
|
|
| | | | | | | | | | | | | | |
organism-modification
|
|
PR:000036569 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)
|
cow-CNGA1/iso:1/Phos:1
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | | | |
modification
|
|
PR:000045378 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2
|
CNGA1/iso:1/Phos:2
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB) and the residue at the position equivalent to Tyr-503 of the amino acid sequence represented by UniProtKB:Q00194-1. This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time has a similar effect, that is decreases the apparent affinity for cGMP. Example: UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:23032687, PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | | | | | |
organism-modification
|
|
PR:000045379 |
cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)
|
cow-CNGA1/iso:1/Phos:2
|
"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]
|
|
|
|
|
|
|
| | | | | | |
| | | | | |
gene
|
|
PR:000000696 |
cyclic nucleotide-gated channel alpha-3
|
CNGA3
|
"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA3 gene or a 1:1 ortholog thereof. These proteins are the alpha subunits of the cone cyclic nucleotide-gated cation channel. This channel generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q16281 |
cyclic nucleotide-gated channel alpha-3 (human)
|
hCNGA3
|
"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16281]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000741 |
cyclic nucleotide-gated channel alpha-3 sequence variant R283Q (human)
|
hCNGA3/var:R283Q
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has a Gln residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000742 |
cyclic nucleotide-gated channel alpha-3 sequence variant T291R (human)
|
hCNGA3/var:T291R
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has an Arg residue at the position equivalent to Thr-291 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Thr-291, CHEBI:29952." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000743 |
cyclic nucleotide-gated channel alpha-3 sequence variant G557R (human)
|
hCNGA3/var:G557R
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has an Arg residue at the position equivalent to Gly-557 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Gly-557, CHEBI:29952." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000744 |
cyclic nucleotide-gated channel alpha-3 sequence variant V529M (human)
|
hCNGA3/var:V529M
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has a Met residue at the position equivalent to Val-529 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Val-529, CHEBI:16044." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000745 |
cyclic nucleotide-gated channel alpha-3 sequence variant R283W (human)
|
hCNGA3/var:R283W
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has a Trp residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:29954." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000746 |
cyclic nucleotide-gated channel alpha-3 sequence variant F547L (human)
|
hCNGA3/var:F547L
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has a Leu residue at the position equivalent to Phe-547 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Phe-547, CHEBI:30006." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000747 |
cyclic nucleotide-gated channel alpha-3 sequence variant R410W (human)
|
hCNGA3/var:R410W
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has a Trp residue at the position equivalent to Arg-410 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-410, CHEBI:29954." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000748 |
cyclic nucleotide-gated channel alpha-3 sequence variant P163L (human)
|
hCNGA3/var:P163L
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has a Leu residue at the position equivalent to Pro-163 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Pro-163, CHEBI:30006." [PMID:9662398, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q16281-1 |
cyclic nucleotide-gated channel alpha-3 isoform 1 (human)
|
hCNGA3/iso:1
|
"A cyclic nucleotide-gated channel alpha-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q16281-2 |
cyclic nucleotide-gated channel alpha-3 isoform h2 (human)
|
hCNGA3/iso:h2
|
"A cyclic nucleotide-gated channel alpha-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-2." [PRO:DNx, UniProtKB:Q16281]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q16281-3 |
cyclic nucleotide-gated channel alpha-3 isoform h3 (human)
|
hCNGA3/iso:h3
|
"A cyclic nucleotide-gated channel alpha-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-3." [PRO:DNx, UniProtKB:Q16281]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000081665 |
cyclic nucleotide-gated channel alpha-3 phosphorylated 1 (human)
|
hCNGA3/Phos:1
|
"A cyclic nucleotide-gated channel alpha-3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-341 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Ser-341, MOD:00046." [IEDB_epitope:2147051, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q90805 |
cyclic nucleotide-gated channel cone photoreceptor subunit alpha (chicken)
|
chick-CNGA3
|
"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of chicken." [PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q94A76 |
potassium channel GORK (Arabidopsis thaliana)
|
At-CNGA3
|
"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9ER33 |
cyclic nucleotide-gated channel alpha-3 (rat)
|
rCNGA3
|
"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of rat." [OMA:Q9ER33, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9ER33-1 |
cyclic nucleotide-gated channel alpha-3 isoform r1 (rat)
|
rCNGA3/iso:r1
|
"A cyclic nucleotide-gated channel alpha-3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER33-1." [PRO:DNx, UniProtKB:Q9ER33]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9ER33-2 |
cyclic nucleotide-gated channel alpha-3 isoform r2 (rat)
|
rCNGA3/iso:r2
|
"A cyclic nucleotide-gated channel alpha-3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER33-2." [PRO:DNx, UniProtKB:Q9ER33]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9JJZ8 |
cyclic nucleotide-gated channel alpha-3 (mouse)
|
mCNGA3
|
"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of mouse." [OMA:Q9JJZ8, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9JJZ8-1 |
cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)
|
mCNGA3/iso:m1
|
"A cyclic nucleotide-gated channel alpha-3 isoform m1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9JJZ8]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000739 |
cyclic nucleotide-gated channel alpha-3 isoform 1
|
CNGA3/iso:1
|
"A cyclic nucleotide-gated channel alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q16281-1 |
cyclic nucleotide-gated channel alpha-3 isoform 1 (human)
|
hCNGA3/iso:1
|
"A cyclic nucleotide-gated channel alpha-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000740 |
cyclic nucleotide-gated channel alpha-3 isoform m1
|
CNGA3/iso:m1
|
"A cyclic nucleotide-gated channel alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJZ8-1 or a 1:1 ortholog thereof." [PMID:10813773, PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9JJZ8-1 |
cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)
|
mCNGA3/iso:m1
|
"A cyclic nucleotide-gated channel alpha-3 isoform m1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9JJZ8]
|
Yes |
|
|
|
|
|
| | | | | | |
| | | | | |
gene
|
|
PR:000000698 |
cyclic nucleotide-gated channel alpha-2
|
CNGA2
|
"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA2 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
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| | | |
organism-gene
|
|
PR:Q00195 |
cyclic nucleotide-gated channel alpha-2 (rat)
|
rCNGA2
|
"A cyclic nucleotide-gated channel alpha-2 that is encoded in the genome of rat." [OMA:Q00195, PRO:DNx]
|
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| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q16280 |
cyclic nucleotide-gated channel alpha-2 (human)
|
hCNGA2
|
"A cyclic nucleotide-gated channel alpha-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16280]
|
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| | | |
organism-gene
|
|
PR:Q62398 |
cyclic nucleotide-gated channel alpha-2 (mouse)
|
mCNGA2
|
"A cyclic nucleotide-gated channel alpha-2 that is encoded in the genome of mouse." [OMA:Q62398, PRO:DNx]
|
Yes |
|
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| | | | | |
gene
|
|
PR:000005631 |
cyclic nucleotide-gated channel alpha-4
|
CNGA4
|
"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA4 gene or a 1:1 ortholog thereof." [PRO:DNx]
|
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| | | |
organism-gene
|
|
PR:Q3UW12 |
cyclic nucleotide-gated channel alpha-4 (mouse)
|
mCNGA4
|
"A cyclic nucleotide-gated channel alpha-4 that is encoded in the genome of mouse." [OMA:Q3UW12, PRO:DNx]
|
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| |
organism-sequence
|
|
PR:Q3UW12-1 |
cyclic nucleotide-gated channel alpha-4 isoform 1 (mouse)
|
mCNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
|
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| |
organism-sequence
|
|
PR:Q3UW12-2 |
cyclic nucleotide-gated channel alpha-4 isoform m2 (mouse)
|
mCNGA4/iso:m2
|
"A cyclic nucleotide-gated channel alpha-4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UW12-2." [PRO:DNx, UniProtKB:Q3UW12]
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| | | |
organism-gene
|
|
PR:Q64359 |
cyclic nucleotide-gated channel alpha-4 (rat)
|
rCNGA4
|
"A cyclic nucleotide-gated channel alpha-4 that is encoded in the genome of rat." [OMA:Q64359, PRO:DNx]
|
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| |
organism-sequence
|
|
PR:Q64359-1 |
cyclic nucleotide-gated channel alpha-4 isoform 1 (rat)
|
rCNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
|
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| | | |
organism-gene
|
|
PR:Q8IV77 |
cyclic nucleotide-gated channel alpha-4 (human)
|
hCNGA4
|
"A cyclic nucleotide-gated channel alpha-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IV77]
|
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| |
organism-sequence
|
|
PR:Q8IV77-1 |
cyclic nucleotide-gated channel alpha-4 isoform 1 (human)
|
hCNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]
|
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| |
organism-sequence
|
|
PR:Q8IV77-2 |
cyclic nucleotide-gated channel alpha-4 isoform h2 (human)
|
hCNGA4/iso:h2
|
"A cyclic nucleotide-gated channel alpha-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IV77-2." [PRO:DNx, UniProtKB:Q8IV77]
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| | | |
sequence
|
|
PR:000041693 |
cyclic nucleotide-gated channel alpha-4 isoform 1
|
CNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IV77-1 or a 1:1 ortholog thereof." [PRO:DNx]
|
|
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| |
organism-sequence
|
|
PR:Q3UW12-1 |
cyclic nucleotide-gated channel alpha-4 isoform 1 (mouse)
|
mCNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
|
|
|
|
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|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q64359-1 |
cyclic nucleotide-gated channel alpha-4 isoform 1 (rat)
|
rCNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
|
|
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| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q8IV77-1 |
cyclic nucleotide-gated channel alpha-4 isoform 1 (human)
|
hCNGA4/iso:1
|
"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]
|
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family
|
|
PR:000000674 |
cyclic nucleotide-gated channel beta subunit
|
CATSPERB
|
"A cyclic nucleotide-regulated channel protein that is the modulatory subunit of the cyclic nucleotide-gated channel (CNG channel). It consists of amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. CNG beta subunits combine with the alpha subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however the beta subunits are not able to form functional channels by themselves." [PRO:CNA]
|
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| | | | | |
gene
|
|
PR:000000697 |
cyclic nucleotide-gated channel beta-3
|
CNGB3
|
"A cyclic nucleotide-gated channel beta subunit that is a translation product of the human CNGB3 gene or a 1:1 ortholog thereof. Many members of this class are subunits of the cone cyclic nucleotide-gated cation channel, which generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA]
|
|
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| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9JJZ9 |
cyclic nucleotide-gated channel beta-3 (mouse)
|
mCNGB3
|
"A cyclic nucleotide-gated channel beta-3 that is encoded in the genome of mouse." [OMA:Q9JJZ9, PRO:DNx]
|
|
|
|
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|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9JJZ9-1 |
cyclic nucleotide-gated channel beta-3 isoform 1 (mouse)
|
mCNGB3/iso:1
|
"A cyclic nucleotide-gated channel beta-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9NQW8 |
cyclic nucleotide-gated channel beta-3 (human)
|
hCNGB3
|
"A cyclic nucleotide-gated channel beta-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NQW8]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000752 |
cyclic nucleotide-gated channel beta-3 sequence variant S435F (human)
|
hCNGB3/var:S435F
|
"A cyclic nucleotide-gated channel beta-3 (human) that has a Phe residue at the position equivalent to Ser-435 of the amino acid sequence represented by UniProtKB:Q9NQW8-1. Example: UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997." [PMID:10888875, PMID:10958649, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9NQW8-1 |
cyclic nucleotide-gated channel beta-3 isoform 1 (human)
|
hCNGB3/iso:1
|
"A cyclic nucleotide-gated channel beta-3 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9NQW8-2 |
cyclic nucleotide-gated channel beta-3 isoform 2 (human)
|
hCNGB3/iso:2
|
"A cyclic nucleotide-gated channel beta-3 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000749 |
cyclic nucleotide-gated channel beta-3 isoform 1
|
CNGB3/iso:1
|
"A cyclic nucleotide-gated channel beta-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJZ9-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
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|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9JJZ9-1 |
cyclic nucleotide-gated channel beta-3 isoform 1 (mouse)
|
mCNGB3/iso:1
|
"A cyclic nucleotide-gated channel beta-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000750 |
cyclic nucleotide-gated channel beta-3 isoform 2
|
CNGB3/iso:2
|
"A cyclic nucleotide-gated channel beta-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NQW8-2 or a 1:1 ortholog thereof." [PMID:10888875, PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9NQW8-2 |
cyclic nucleotide-gated channel beta-3 isoform 2 (human)
|
hCNGB3/iso:2
|
"A cyclic nucleotide-gated channel beta-3 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000751 |
cyclic nucleotide-gated channel beta-3 isoform 3
|
CNGB3/iso:3
|
"A cyclic nucleotide-gated channel beta-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NQW8-1 or a 1:1 ortholog thereof." [PMID:10958649, PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9NQW8-1 |
cyclic nucleotide-gated channel beta-3 isoform 1 (human)
|
hCNGB3/iso:1
|
"A cyclic nucleotide-gated channel beta-3 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NQW8]
|
|
|
|
|
|
|
| | | | | | |
| | | | | |
gene
|
|
PR:000005632 |
cyclic nucleotide-gated channel beta-1
|
CNGB1
|
"A cyclic nucleotide-gated channel beta subunit that is a translation product of the human CNGB1 gene or a 1:1 ortholog thereof." [PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q14028 |
cyclic nucleotide-gated channel beta-1 (human)
|
hCNGB1
|
"A cyclic nucleotide-gated channel beta-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14028]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q14028-1 |
cyclic nucleotide-gated channel beta-1 isoform hRCNC2B (human)
|
hCNGB1/iso:hRCNC2B
|
"A cyclic nucleotide-gated channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-1." [PRO:DNx, UniProtKB:Q14028]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q14028-2 |
cyclic nucleotide-gated channel beta-1 isoform hRCNC2A (human)
|
hCNGB1/iso:hRCNC2A
|
"A cyclic nucleotide-gated channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-2." [PRO:DNx, UniProtKB:Q14028]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q14028-3 |
cyclic nucleotide-gated channel beta-1 isoform hGARP2 (human)
|
hCNGB1/iso:hGARP2
|
"A cyclic nucleotide-gated channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-3." [PRO:DNx, UniProtKB:Q14028]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q14028-4 |
cyclic nucleotide-gated channel beta-1 isoform h4 (human)
|
hCNGB1/iso:h4
|
"A cyclic nucleotide-gated channel beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14028-4." [PRO:DNx, UniProtKB:Q14028]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000065272 |
cyclic nucleotide-gated channel beta-1 deaminated 1 (human)
|
hCNGB1/Deam:1
|
"A cyclic nucleotide-gated channel beta-1 (human) that has been deaminated on the residue at the position equivalent to Gln-1003 of the amino acid sequence represented by UniProtKB:Q14028-1. Example: UniProtKB:Q14028-1, Gln-1003, MOD:00685." [IEDB_epitope:1855197, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000068737 |
cyclic nucleotide-gated channel beta-1 phosphorylated 1 (human)
|
hCNGB1/Phos:1
|
"A cyclic nucleotide-gated channel beta-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-845 of the amino acid sequence represented by UniProtKB:Q14028-1. Example: UniProtKB:Q14028-1, Thr-845, MOD:00047." [IEDB_epitope:2145906, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000071055 |
cyclic nucleotide-gated channel beta-1 phosphorylated 2 (human)
|
hCNGB1/Phos:2
|
"A cyclic nucleotide-gated channel beta-1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-735 of the amino acid sequence represented by UniProtKB:Q14028-1. Example: UniProtKB:Q14028-1, Ser-735, MOD:00046." [IEDB_epitope:2147205, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q39128 |
potassium channel KAT1 (Arabidopsis thaliana)
|
At-CNGB1
|
"A cyclic nucleotide-gated channel beta-1 that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]
|
|
|
|
|
|
|
| | | | |
| | | | | | | |
family
|
|
PR:000000676 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
|
CATSPERB
|
"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The N terminus has a conserved domain that is also present in other voltage-gated potassium and sodium channels. The carboxyl-terminal region contains the cyclic nucleotide-binding domain (CNBD). In addition, there is a structural element called the C-linker, the region connecting the CNBD to the S6 segment, which couples conformational changes in the ligand-binding domain to channel activation. Subunits combine to form the HCN channels. In common with CNG channels, HCN are cation channels that are modulated by cyclic nucleotide binding. Unlike CNG channels, HCN channels are voltage-gated, and are weakly selective for potassium. In contrast to most other voltage-gated channels, HCN channels open upon hyperpolarization and close at positive potential. HCN channels act as a pacemaker by regulating neuronal and cardiac firing rate, but also function as a regulator of membrane resting potential and resistance." [PMID:16382102]
|
|
|
|
|
|
|
| | | | | | |
| | | | | |
gene
|
|
PR:000000705 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
|
HCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN1 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:O60741 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (human)
|
hHCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O60741]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:O88704 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (mouse)
|
mHCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of mouse." [OMA:O88704, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:O88704-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse)
|
mHCN1/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036573 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
|
mHCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:12928435, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9JKB0 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (rat)
|
rHCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of rat." [OMA:Q9JKB0, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000755 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1
|
HCN1/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88704-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:O88704-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse)
|
mHCN1/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036573 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
|
mHCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:12928435, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
modification
|
|
PR:000000935 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 glycosylated form
|
HCN1/iso:1/GlycoRes+
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | | | |
modification
|
|
PR:000000984 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1
|
HCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 glycosylated form with N-glycosylation at the N-linked glycosylation consensus sequence (Nx[ST]) in the extracellular domain between S5 and S6 transmembrane segments. Example: UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:17988239]
|
|
|
|
|
|
|
| | | | | | | | | | | | | | |
organism-modification
|
|
PR:000036573 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
|
mHCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:12928435, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | |
| | | | | |
gene
|
|
PR:000000706 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
|
HCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN2 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:O88703 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)
|
mHCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of mouse." [OMA:O88703, PRO:DNx]
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| |
organism-sequence
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|
PR:O88703-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
|
mHCN2/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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organism-modification
|
|
PR:000036574 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
|
mHCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
|
Yes |
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| |
organism-modification
|
|
PR:000046119 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse)
|
mHCN2/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been phosphorylated at Ser-641. UniProtKB:O88703, Ser-641, MOD:00046." [iPTMnet:O88703, PMID:21347269]
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| |
organism-modification
|
|
PR:000084040 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 deaminated 1 (mouse)
|
mHCN2/Deam:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been deaminated on the residue at the position equivalent to Gln-694 of the amino acid sequence represented by UniProtKB:O88703. UniProtKB:O88703, Gln-694, MOD:00685." [IEDB_epitope:2136599, PRO:DNx]
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organism-gene
|
|
PR:Q9JKA9 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat)
|
rHCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of rat." [OMA:Q9JKA9, PRO:DNx]
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organism-gene
|
|
PR:Q9UL51 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)
|
hHCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UL51]
|
Yes |
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| | | |
sequence
|
|
PR:000000756 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1
|
HCN2/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88703-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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| |
organism-sequence
|
|
PR:O88703-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
|
mHCN2/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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organism-modification
|
|
PR:000036574 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
|
mHCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
|
Yes |
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| |
modification
|
|
PR:000000936 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form
|
HCN2/iso:1/GlycoRes+
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
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modification
|
|
PR:000000985 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1
|
HCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form with N-glycosylation at the N-linked glycosylation consensus sequence (Nx[ST]) in the extracellular domain between S5 and S6 transmembrane segments. Example: UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435]
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organism-modification
|
|
PR:000036574 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
|
mHCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
|
Yes |
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gene
|
|
PR:000000707 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
|
HCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN3 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:G5EFJ9 |
potassium voltage-gated channel unc-103 (worm)
|
HCN3 (worm)
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of worm." [OMA:G5EFJ9, PRO:DNx]
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| |
organism-sequence
|
|
PR:G5EFJ9-1 |
potassium voltage-gated channel unc-103 isoform a (worm)
|
HCN3/iso:a (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-1." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-10 |
potassium voltage-gated channel unc-103 isoform j (worm)
|
HCN3/iso:j (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-10." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-2 |
potassium voltage-gated channel unc-103 isoform c (worm)
|
HCN3/iso:c (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-2." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-3 |
potassium voltage-gated channel unc-103 isoform b (worm)
|
HCN3/iso:b (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-3." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-4 |
potassium voltage-gated channel unc-103 isoform h (worm)
|
HCN3/iso:h (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-4." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-5 |
potassium voltage-gated channel unc-103 isoform e (worm)
|
HCN3/iso:e (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-5." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-6 |
potassium voltage-gated channel unc-103 isoform d (worm)
|
HCN3/iso:d (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-6." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-7 |
potassium voltage-gated channel unc-103 isoform g (worm)
|
HCN3/iso:g (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-7." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-8 |
potassium voltage-gated channel unc-103 isoform f (worm)
|
HCN3/iso:f (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-8." [PRO:DNx, UniProtKB:G5EFJ9]
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| |
organism-sequence
|
|
PR:G5EFJ9-9 |
potassium voltage-gated channel unc-103 isoform i (worm)
|
HCN3/iso:i (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-9." [PRO:DNx, UniProtKB:G5EFJ9]
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|
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| | | |
organism-gene
|
|
PR:O88705 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (mouse)
|
mHCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of mouse." [OMA:O88705, PRO:DNx]
|
|
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| |
organism-sequence
|
|
PR:O88705-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse)
|
mHCN3/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
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|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000029934 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse)
|
mHCN3/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 in mouse. UniProtKB:O88705, Ser-633, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
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| | | |
organism-gene
|
|
PR:Q9JKA8 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (rat)
|
rHCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of rat." [OMA:Q9JKA8, PRO:DNx]
|
|
|
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| | | |
organism-gene
|
|
PR:Q9P1Z3 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (human)
|
hHCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9P1Z3]
|
|
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| | | |
sequence
|
|
PR:000000757 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1
|
HCN3/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88705-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
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|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:O88705-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse)
|
mHCN3/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
modification
|
|
PR:000029933 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1
|
HCN3/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that has been phosphorylated on the residue at the position equivalent to Ser-633 of the amino acid sequence represented by UniProtKB:O88705. Example: UniProtKB:O88705, Ser-633, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000029934 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse)
|
mHCN3/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 in mouse. UniProtKB:O88705, Ser-633, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
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gene
|
|
PR:000000708 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
|
HCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN4 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
|
|
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| | | |
organism-gene
|
|
PR:O70507 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (mouse)
|
mHCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of mouse." [OMA:O70507, PRO:DNx]
|
|
|
|
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|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000029936 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
|
mHCN4/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 in mouse. UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9JKA7 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rat)
|
rHCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of rat." [OMA:Q9JKA7, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9TV66 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit)
|
rabbit-HCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of rabbit." [PRO:DAN]
|
|
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| |
organism-sequence
|
|
PR:Q9TV66-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform r1 (rabbit)
|
rabbit-HCN4/iso:r1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9TV66-1." [PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
organism-gene
|
|
PR:Q9Y3Q4 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
|
hHCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y3Q4]
|
|
|
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| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000759 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
|
hHCN4/var:D553N
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Asn residue at the position equivalent to Asp-553 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347." [PMID:15123648, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:000000760 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
|
hHCN4/var:S672R
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Arg residue at the position equivalent to Ser-672 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952." [PMID:16407510, PRO:CNA, PRO:DAN]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9Y3Q4-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
|
hHCN4/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | | |
sequence
|
|
PR:000000758 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1
|
HCN4/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y3Q4-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
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|
| | | | | | | | | | |
| |
organism-sequence
|
|
PR:Q9Y3Q4-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
|
hHCN4/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
| |
modification
|
|
PR:000002604 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 unmodified form
|
HCN4/iso:1/UnMod
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | | |
modification
|
|
PR:000029935 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1
|
HCN4/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that has been phosphorylated on the residue at the position equivalent to Ser-921 of the amino acid sequence represented by UniProtKB:O70507. Example: UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | | | |
| |
organism-modification
|
|
PR:000029936 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
|
mHCN4/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 in mouse. UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
