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Protein Ontology report - TGF-beta receptor type-1, signal peptide removed form (human)

PR:000049432 - http://purl.obolibrary.org/obo/PR_000049432

Protein Forms

Complex

Annotations

Ontology Information

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GPI

PRO ID

PR:000049432

PRO name

TGF-beta receptor type-1, signal peptide removed form (human)

Synonyms

PRO-Short-label:	EXACT:	hTGFBR1/SigPep-
PRO-proteoform-std:	EXACT:	UniProtKB:P36897, 34-503
PRO-proteoform-ftid:	EXACT:	PRO_0000024423

Definition

"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]

PRO Category

organism-modification

Parent

PR:000025932 TGF-beta receptor type-1, signal peptide removed form
PR:P36897 TGF-beta receptor type-1 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	0	Organism-Modification	11

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

organism-modification

PR:000049432 TGF-beta receptor type-1, signal peptide removed form (human)

hTGFBR1/SigPep-

organism-modification

PR:000036432 TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-

Yes

organism-modification

PR:000025959 TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1

Yes

organism-modification

PR:000049433 TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)

hTGFBR1/SigPep-/UbiqLys+

organism-modification

PR:000060809 TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)

hTGFBR1/var:G52R/SigPep-

organism-modification

PR:000060890 TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:R414*/SigPep-/Phos:1

organism-modification

PR:000061254 TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)

hTGFBR1/var:P83L/SigPep-

organism-modification

PR:000061891 TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)

hTGFBR1/var:P83S/SigPep-

organism-modification

PR:000063489 TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)

hTGFBR1/var:C41Y/SigPep-

organism-modification

PR:000063569 TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)

hTGFBR1/var:N45S/SigPep-

organism-modification

PR:000064307 TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:W242*/SigPep-/Phos:1

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hTGFBR1/SigPep- forms found in complexes

hTGFBR1/SigPep- Component	Complexes
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1	PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046\|Thr-185/Thr-186, MOD:00047	acts_upstream_of_or_within	GO:0006468 protein phosphorylation	PMID:7774578
		GO:0007165 signal transduction	PMID:8242743
		GO:0007181 transforming growth factor beta receptor complex assembly	PMID:8947046
	enables	GO:0005025 transforming growth factor beta receptor activity, type I	PMID:7774578; PMID:8947046
	located_in	GO:0005886 plasma membrane	PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- UniProtKB:P36897-1, 34-503	acts_upstream_of_or_within	GO:0007165 signal transduction	PMID:8242743
	acts_upstream_of_or_within	GO:0007181 transforming growth factor beta receptor complex assembly	PMID:8242743
	located_in	GO:0005886 plasma membrane	PMID:8242743