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Protein Ontology report - IgA1 immunoglobulin complex, circulating (human)
PR:000050159 - http://purl.obolibrary.org/obo/PR_000050159
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000050159   
  PRO nameIgA1 immunoglobulin complex, circulating (human) 
  Synonyms
PRO-Short-label: EXACT:hIgA1/circulating
Other: EXACT:IgA1 antibody (human)
  Definition"An IgA immunoglobulin complex, circulating in human that is composed of (in monomeric form) two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD] 
  CommentRequested by=HIPC. Requested by=CL. 
  PRO Categoryorganism-complex 
  ParentG0071746 IgA immunoglobulin complex, circulating
PR:000050032 immunoglobulin complex (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex0                                                  Organism-Complex 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-complex


PR:000050159
IgA1 immunoglobulin complex, circulating (human)
hIgA1/circulating
"An IgA immunoglobulin complex, circulating in human that is composed of (in monomeric form) two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]

organism-complex


PR:000050163
monomeric IgA1 immunoglobulin complex (human)
h(IgA1)monomeric
"An IgA1 immunoglobulin complex, circulating (human) that is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]

Yes
organism-complex


PR:000050165
polymeric IgA1 immunoglobulin complex (human)
h(IgA1)polymeric
"An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]

organism-complex


PR:000050166
dimeric IgA1 immunoglobulin complex (human)
h(IgA1)dimeric
"A polymeric IgA1 immunoglobulin complex (human) that is composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]

organism-complex


PR:000050167
secretory polymeric IgA1 immunoglobulin complex (human)
h(IgA1/secretory)polymeric
"A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]

organism-complex


PR:000050168
secretory dimeric IgA1 immunoglobulin complex (human)
h(IgA1/secretory)dimeric
"A polymeric IgA1 immunoglobulin complex (human) that is a dimer of secretory IgA1 immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]

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hIgA1/circulating forms found in complexes   

hIgA1/circulating Component
 Complexes
PR:000050163 h(IgA1)monomeric PR:000050165 polymeric IgA1 immunoglobulin complex (human)
PR:000050166 dimeric IgA1 immunoglobulin complex (human)
PR:000050167 secretory polymeric IgA1 immunoglobulin complex (human)
PR:000050168 secretory dimeric IgA1 immunoglobulin complex (human)