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Protein Ontology report - polymeric IgA1 immunoglobulin complex (human)
PR:000050165 -
http://purl.obolibrary.org/obo/PR_000050165
Protein Forms
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000050165
PRO name
polymeric IgA1 immunoglobulin complex (human)
Synonyms
PRO-Short-label
:
EXACT:
h(IgA1)polymeric
Other
:
EXACT:
pIgA1 antibody (human) | polymeric IgA1 antibody (human)
Definition
"An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add,
ISBN:0781765196
,
PMID:16362985
, PRO:ADD]
Comment
Requested by=HIPC. Requested by=CL. Dimeric IgA1 is by far the most common form of polymeric IgA1. In human only the IgA1 isotype is capable of a polymeric forms.
PRO Category
organism-complex
Parent
PR:000050159
IgA1 immunoglobulin complex, circulating (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
0
Organism-Complex
4
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-complex
PR:000050165
polymeric IgA1 immunoglobulin complex (human)
h(IgA1)polymeric
"An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
organism-complex
PR:000050166
dimeric IgA1 immunoglobulin complex (human)
h(IgA1)dimeric
"A polymeric IgA1 immunoglobulin complex (human) that is composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
organism-complex
PR:000050167
secretory polymeric IgA1 immunoglobulin complex (human)
h(IgA1/secretory)polymeric
"A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
organism-complex
PR:000050168
secretory dimeric IgA1 immunoglobulin complex (human)
h(IgA1/secretory)dimeric
"A polymeric IgA1 immunoglobulin complex (human) that is a dimer of secretory IgA1 immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
