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Protein Ontology report - rep gene translation product (SARS-CoV-2)
PR:000050263 - http://purl.obolibrary.org/obo/PR_000050263
 
  Protein Forms      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000050263   
  PRO namerep gene translation product (SARS-CoV-2) 
  Synonyms
PRO-Short-label: EXACT:ORF1ab (SARS2)
Gene-based: RELATED:GU280_gp01 | ORF1a-1b | ORF1ab | rep
  Definition"A protein that is a translation product of the ORF1ab gene in SARS-CoV-2." [PRO:DAN] 
  CommentNote: The rep gene produces two translation products, one with (ORF1ab) and one without (ORF1a) -1 ribosomal frameshifting. Both products are further processed by proteolytic cleavage to yield 10 identical chains, while 1 additional chain is unique to ORF1a and 5 additional chains are unique to ORF1ab. 
  PRO Categoryorganism-gene 
  ParentPR:000050262 severe acute respiratory syndrome coronavirus 2 protein
  Gene TemplateNCBIGene:43740578 ORF1ab (Severe acute respiratory syndrome coronavirus 2)
  TaxonNCBITaxon:2697049 Severe acute respiratory syndrome coronavirus 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 20                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:000050263
rep gene translation product (SARS-CoV-2)
ORF1ab (SARS2)
"A protein that is a translation product of the ORF1ab gene in SARS-CoV-2." [PRO:DAN]

organism-sequence


PR:P0DTC1-1
replicase polyprotein 1a (SARS-CoV-2)
rep/iso:ORF1a (SARS2)
"A rep gene translation product (SARS-CoV-2) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P0DTC1-1." [GenPept:YP_009725295, PRO:DAN, UniProtKB:P0DTC1]

organism-modification


PR:000050282
ORF1a proteolytic cleavage product (SARS-CoV-2)
ORF1a/ClvPrd (SARS2)
"A replicase polyprotein 1a (SARS-CoV-2) that has been processed by proteolytic cleavage." [PRO:DAN]

organism-modification


PR:000050280
non-structural protein 11 (SARS-CoV-2)
rep/Clv:nsp11 (SARS2)
"An ORF1a proteolytic cleavage product (SARS-CoV-2) that is the C-terminal portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1a (SARS-CoV-2) between residues 4392-4393. UniProtKB:P0DTC1, 4393-4405." [GenPept:YP_009725312, PRO:DAN, UniProtKB:P0DTC1]

organism-sequence


PR:P0DTD1-1
replicase polyprotein 1ab (SARS-CoV-2)
rep/iso:ORF1ab (SARS2)
"A rep gene translation product (SARS-CoV-2) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P0DTD1-1. Requires ribosomal frameshifting." [GenPept:YP_009724389, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050283
ORF1ab proteolytic cleavage product (SARS-CoV-2)
ORF1ab/ClvPrd (SARS2)
"A replicase polyprotein 1ab (SARS-CoV-2) that has been processed by proteolytic cleavage." [PRO:DAN]

organism-modification


PR:000050284
RNA-directed RNA polymerase nsp12 (SARS-CoV-2)
ORF1ab/Clv:nsp12 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 4392-4393 and 5324-5325. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725307, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050285
helicase nsp13 (SARS-CoV-2)
ORF1ab/Clv:nsp13 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5324-5325 and 5925-5926. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725308, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050286
proofreading exoribonuclease nsp14 (SARS-CoV-2)
ORF1ab/Clv:nsp14 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5925-5926 and 6452-6453. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725309, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050287
uridylate-specific endoribonuclease nsp15 (SARS-CoV-2)
ORF1ab/Clv:nsp15 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6452-6453 and 6798-6799. UniProtKB:P0DTD1, 6453-6798." [GenPept:YP_009725310, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050288
2'-O-methyltransferase nsp16 (SARS-CoV-2)
ORF1ab/Clv:nsp16 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the C-terminal portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6798-6799. UniProtKB:P0DTD1, 6453-6798." [GenPept:YP_009725311, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050281
rep gene proteolytic cleavage product (SARS-CoV-2)
rep/ClvPrd (SARS2)
"A rep gene translation product (SARS-CoV-2) that has been processed by proteolytic cleavage." [PRO:DAN]

organism-modification


PR:000050270
host translation inhibitor nsp1 (SARS-CoV-2)
rep/Clv:nsp1 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the N-terminal portion produced by the enzymatic action of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 180-181." [GenPept:YP_009725297, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050271
non-structural protein 2 (SARS-CoV-2)
rep/Clv:nsp2 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 180-181 and 818-819." [GenPept:YP_009725298, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050272
papain-like proteinase nsp3 (SARS-CoV-2)
rep/Clv:nsp3 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the autocatalytic action of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 818-819 and 2763-2764." [GenPept:YP_009725299, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050273
non-structural protein 4 (SARS-CoV-2)
rep/Clv:nsp4 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the combined actions of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 2763-2764, and 3CL-PRO (nsp5) when it cleaves the precursor between residues 3263-3264." [GenPept:YP_009725300, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050274
3C-like proteinase nsp5 (SARS-CoV-2)
rep/Clv:nsp5 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the autocatalytic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 3263-3264 and 3569-3570." [GenPept:YP_009725301, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050275
non-structural protein 6 (SARS-CoV-2)
rep/Clv:nsp6 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 3569-3570 and 3859-3860." [GenPept:YP_009725302, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050276
non-structural protein 7 (SARS-CoV-2)
rep/Clv:nsp7 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 3859-3860 and 3942-3943." [GenPept:YP_009725303, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050277
non-structural protein 8 (SARS-CoV-2)
rep/Clv:nsp8 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 3942-3943 and 4140-4141." [GenPept:YP_009725304, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050278
non-structural protein 9 (SARS-CoV-2)
rep/Clv:nsp9 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 4140-4141 and 4253-4254." [GenPept:YP_009725305, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050279
non-structural protein 10 (SARS-CoV-2)
rep/Clv:nsp10 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 4253-4254 and 4392-4393." [GenPept:YP_009725306, PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]

organism-modification


PR:000050282
ORF1a proteolytic cleavage product (SARS-CoV-2)
ORF1a/ClvPrd (SARS2)
"A replicase polyprotein 1a (SARS-CoV-2) that has been processed by proteolytic cleavage." [PRO:DAN]

organism-modification


PR:000050280
non-structural protein 11 (SARS-CoV-2)
rep/Clv:nsp11 (SARS2)
"An ORF1a proteolytic cleavage product (SARS-CoV-2) that is the C-terminal portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1a (SARS-CoV-2) between residues 4392-4393. UniProtKB:P0DTC1, 4393-4405." [GenPept:YP_009725312, PRO:DAN, UniProtKB:P0DTC1]

organism-modification


PR:000050283
ORF1ab proteolytic cleavage product (SARS-CoV-2)
ORF1ab/ClvPrd (SARS2)
"A replicase polyprotein 1ab (SARS-CoV-2) that has been processed by proteolytic cleavage." [PRO:DAN]

organism-modification


PR:000050284
RNA-directed RNA polymerase nsp12 (SARS-CoV-2)
ORF1ab/Clv:nsp12 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 4392-4393 and 5324-5325. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725307, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050285
helicase nsp13 (SARS-CoV-2)
ORF1ab/Clv:nsp13 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5324-5325 and 5925-5926. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725308, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050286
proofreading exoribonuclease nsp14 (SARS-CoV-2)
ORF1ab/Clv:nsp14 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5925-5926 and 6452-6453. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725309, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050287
uridylate-specific endoribonuclease nsp15 (SARS-CoV-2)
ORF1ab/Clv:nsp15 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6452-6453 and 6798-6799. UniProtKB:P0DTD1, 6453-6798." [GenPept:YP_009725310, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050288
2'-O-methyltransferase nsp16 (SARS-CoV-2)
ORF1ab/Clv:nsp16 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the C-terminal portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6798-6799. UniProtKB:P0DTD1, 6453-6798." [GenPept:YP_009725311, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050289
NSP2-3 intermediate (SARS-CoV-2)
rep/Clv:nsp2-3 (SARS2)
"A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 180-181 and 2763-2764." [PRO:DAN]