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Protein Ontology report - TGF-beta receptor type-2, signal peptide removed form (human)

PR:000085798 - http://purl.obolibrary.org/obo/PR_000085798

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

GPI

PRO ID

PR:000085798

PRO name

TGF-beta receptor type-2, signal peptide removed form (human)

Synonyms

PRO-Short-label:	EXACT:	hTGFBR2/SigPep-
PRO-proteoform-std:	EXACT:	UniProtKB:P37173, 23-567
	NARROW:	UniProtKB:P37173-1, 23-567
Reactome-displayName:	RELATED:	TGFBR2

Definition

"A TGF-beta receptor type-2 (human) that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567." [PRO:DNx, Reactome:R-HSA-170842]

PRO Category

organism-modification

Parent

PR:000018266 TGF-beta receptor type-2, signal peptide removed form
PR:P37173 TGF-beta receptor type-2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	0	Organism-Modification	9

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

organism-modification

PR:000085798 TGF-beta receptor type-2, signal peptide removed form (human)

hTGFBR2/SigPep-

organism-modification

PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)

hTGFBR2/iso:RII-1/SigPep-

Yes

organism-modification

PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)

hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes

organism-modification

PR:000049434 TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)

hTGFBR2/SigPep-/Nedd:1

organism-modification

PR:000060724 TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)

hTGFBR2/var:Y470D/SigPep-

organism-modification

PR:000062611 TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)

hTGFBR2/var:E526Q/SigPep-

organism-modification

PR:000062709 TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)

hTGFBR2/var:R528C/SigPep-

organism-modification

PR:000062958 TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)

hTGFBR2/var:D522N/SigPep-

organism-modification

PR:000064130 TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)

hTGFBR2/var:R528H/SigPep-

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hTGFBR2/SigPep- forms found in complexes

hTGFBR2/SigPep- Component	Complexes
PR:000025962 hTGFBR2/iso:RII-1/SigPep-/Phos:1	PR:000025963 transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:11483955
GO:0007181 transforming growth factor beta receptor complex assembly	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1310899; PMID:8774881
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0005026 transforming growth factor beta receptor activity, type II	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:11483955
GO:0005515 protein binding	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1850637
GO:0050431 transforming growth factor beta binding	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:11850637; PMID:1310899
Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0016020 membrane	PR:000036408 hTGFBR2/iso:RII-1/SigPep-	PMID:1310899