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Protein Ontology report - inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
PR:O15111 - http://purl.obolibrary.org/obo/PR_O15111
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:O15111   
  PRO nameinhibitor of nuclear factor kappa-B kinase subunit alpha (human) 
  Synonyms
PRO-Short-label: EXACT:hCHUK
Gene-based: RELATED:CHUK | IKKA | TCF16
Other: EXACT:conserved helix-loop-helix ubiquitous kinase (human) | I-kappa-B kinase 1 (human) | I-kappa-B kinase alpha (human) | IkappaB kinase (human) | IkBKA (human) | IKK-1 (human) | IKK-A (human) | IKK-alpha (human) | IKK1 (human) | NFKBIKA (human) | nuclear factor NF-kappa-B inhibitor kinase alpha (human) | TCF-16 (human) | transcription factor 16 (human)
  Definition"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15111
  PRO Categoryorganism-gene 
  ParentPR:000001775 inhibitor of nuclear factor kappa-B kinase subunit alpha
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1974 CHUK (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O15111
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:O15111

inhibitor of nuclear factor kappa-B kinase subunit alpha (human)

hCHUK


"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15111]


Yes
organism-sequence



PR:O15111-1

inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)

hCHUK/iso:1


"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026823

inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)

hCHUK/iso:1/Phos:1


"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]


Yes
organism-modification



PR:000045576

inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 2 (human)

hCHUK/Phos:2


"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated at Thr-23. UniProtKB:O15111, Thr-23, MOD:00047." [iPTMnet:O15111, PMID:10485710, Reactome:R-HSA-177667, Reactome:R-HSA-198615]


organism-modification



PR:000062311

inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 1 (human)

hCHUK/Phos:1


"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated on the residues at the positions equivalent to Ser-176 and Ser-180 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Ser-176/Ser-180, MOD:00046." [PRO:DNx, Reactome:R-HSA-177667]


organism-modification



PR:000065276

inhibitor of nuclear factor kappa-B kinase subunit alpha methylated 1 (human)

hCHUK/Me:1


"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been methylated on the residue at the position equivalent to Thr-319 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Thr-319, MOD:01418." [IEDB_epitope:1319554, PRO:DNx]


organism-modification



PR:000085410

inhibitor of nuclear factor kappa-B kinase subunit alpha deaminated 1 (human)

hCHUK/Deam:1


"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been deaminated on the residue at the position equivalent to Gln-63 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Gln-63, MOD:00685." [IEDB_epitope:1778644, PRO:DNx]


organism-modification



PR:000085871

inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 3 (human)

hCHUK/Phos:3


"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-187 and Tyr-198 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Tyr-187/Tyr-198, MOD:00048." [PRO:DNx, Reactome:R-HSA-9861501]


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hCHUK forms found in complexes   

hCHUK Component
Complexes
PR:000026823 hCHUK/iso:1/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:O15111 hCHUK PR:000026457 IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)