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Protein Ontology report - Rho-associated protein kinase 2 isoform 1 (human)
PR:O75116-1 - http://purl.obolibrary.org/obo/PR_O75116-1
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O75116-1   
  PRO nameRho-associated protein kinase 2 isoform 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hROCK2/iso:1
  Definition"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000000308 Rho-associated protein kinase 2 isoform 1
PR:O75116 Rho-associated protein kinase 2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O75116-1
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human)
hROCK2/iso:1
Yes
organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
hROCK2/iso:1/Clv:1
Yes
organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
hROCK2/iso:1/Phos:1
Yes
organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
hROCK2/iso:1/Phos:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036477 hROCK2/iso:1/Clv:1
UniProtKB:O75116-1, 1-1131		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:15699075
GO:0030036 actin cytoskeleton organization PMID:15699075
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_inGO:0005622 intracellular anatomical structure PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17446864
enablesGO:0004674 protein serine/threonine kinase activity PMID:17446864
located_inGO:0005634 nucleus PMID:15302935
PR:000036479 hROCK2/iso:1/Phos:2
UniProtKB:O75116-1, Thr-1078, MOD:00047		 acts_upstream_of_or_withinGO:0042770 signal transduction in response to DNA damage PMID:17525332
PR:O75116-1 hROCK2/iso:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:9933571
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:9933571
GO:0031267 small GTPase binding PMID:11350930
located_inGO:0005622 intracellular anatomical structure PMID:16574662