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Protein Ontology report - epidermal growth factor receptor (human)
PR:P00533 -
http://purl.obolibrary.org/obo/PR_P00533
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:P00533
PRO name
epidermal growth factor receptor (human)
Synonyms
PRO-Short-label
:
EXACT:
hEGFR
Gene-based
:
RELATED:
EGFR | ERBB | ERBB1 | HER1
Other
:
EXACT:
proto-oncogene c-ErbB-1 (human) | receptor tyrosine-protein kinase erbB-1 (human)
Definition
"An epidermal growth factor receptor that is encoded in the genome of human." [PRO:DNx,
UniProtKB:P00533
]
PRO Category
organism-gene
Parent
PR:000006933
epidermal growth factor receptor
PR:000029067
Homo sapiens protein
Gene Template
HGNC:3236
EGFR (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
4
Modification
0
Organism-Modification
47
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P00533
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P00533
epidermal growth factor receptor (human)
hEGFR
"An epidermal growth factor receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00533]
organism-sequence
PR:P00533-1
epidermal growth factor receptor isoform 1 (human)
hEGFR/iso:1
"An epidermal growth factor receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000027477
epidermal growth factor receptor isoform 1, signal peptide removed form (human)
hEGFR/iso:1/SigPep-
"An epidermal growth factor receptor isoform 1, signal peptide removed form in human. UniProtKB:P00533-1, 25-1210." [PMID:18789131, PRO:CNA]
organism-modification
PR:000027479
epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human)
hEGFR/iso:1/SigPep-/Phos:1
"An epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048." [PMID:18789131, PRO:PD]
Yes
organism-sequence
PR:P00533-2
epidermal growth factor receptor isoform h2 (human)
hEGFR/iso:h2
"An epidermal growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00533-2." [PRO:DNx, UniProtKB:P00533]
organism-sequence
PR:P00533-3
epidermal growth factor receptor isoform h3 (human)
hEGFR/iso:h3
"An epidermal growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00533-3." [PRO:DNx, UniProtKB:P00533]
organism-sequence
PR:P00533-4
epidermal growth factor receptor isoform h4 (human)
hEGFR/iso:h4
"An epidermal growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00533-4." [PRO:DNx, UniProtKB:P00533]
organism-modification
PR:000028422
epidermal growth factor receptor, signal peptide removed form (human)
hEGFR/SigPep-
"An epidermal growth factor receptor, signal peptide removed form in human. Example: UniProtKB:P00533-1, 25-1210." [PRO:DNx]
Yes
organism-modification
PR:000027477
epidermal growth factor receptor isoform 1, signal peptide removed form (human)
hEGFR/iso:1/SigPep-
"An epidermal growth factor receptor isoform 1, signal peptide removed form in human. UniProtKB:P00533-1, 25-1210." [PMID:18789131, PRO:CNA]
organism-modification
PR:000027479
epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human)
hEGFR/iso:1/SigPep-/Phos:1
"An epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048." [PMID:18789131, PRO:PD]
Yes
organism-modification
PR:000047261
epidermal growth factor receptor, signal peptide removed phosphorylated 1 (human)
hEGFR/SigPep-/Phos:1
"An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified by autocatalysis to include phosphotyrosine at positions 1092, 1110, 1172 and 1197 of the amino acid sequence represented by UniProtKB:P00533. UniProtKB:P00533, 25-1210, Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DAN, Reactome:R-HSA-180287]
organism-modification
PR:000047262
epidermal growth factor receptor, signal peptide removed phosphorylated 2 (human)
hEGFR/SigPep-/Phos:2
"An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 1016, 1069, 1092, 1110, 1172 and 1197 of the amino acid sequence represented by UniProtKB:P00533. UniProtKB:P00533, 25-1210, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-179803, Reactome:R-HSA-8869138]
organism-modification
PR:000049849
epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human)
hEGFR/SigPep-/Phos:3
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER]
Yes
organism-modification
PR:000049850
epidermal growth factor receptor, signal peptide removed unphosphorylated 3 (human)
hEGFR/SigPep-/UnPhos:3
"An epidermal growth factor receptor, signal peptide removed form (human) that lacks phosphorylation on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, PR:000026291." [PMID:10347170, PRO:KER]
organism-modification
PR:000049851
epidermal growth factor receptor, signal peptide removed phosphorylated 4 (human)
hEGFR/SigPep-/Phos:4
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046." [PMID:10347170, PRO:KER]
Yes
organism-modification
PR:000049852
epidermal growth factor receptor, signal peptide removed unphosphorylated 4 (human)
hEGFR/SigPep-/UnPhos:4
"An epidermal growth factor receptor, signal peptide removed form (human) that lacks phosphorylation on the residue at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, PR:000026291." [PMID:10347170, PRO:KER]
organism-modification
PR:000060975
epidermal growth factor receptor sequence variant A289V, signal peptide removed phosphorylated 1 (human)
hEGFR/var:A289V/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30015|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996334]
organism-modification
PR:000060991
epidermal growth factor receptor sequence variant G719C, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G719C/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Cys residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29950|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1177530]
organism-modification
PR:000061152
epidermal growth factor receptor sequence variant G719S, signal peptide removed form (human)
hEGFR/var:G719S/SigPep-
"An epidermal growth factor receptor (human) that has a Ser residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-1169418]
organism-modification
PR:000061330
epidermal growth factor receptor sequence variant A289D, signal peptide removed phosphorylated 1 (human)
hEGFR/var:A289D/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has an Asp residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:29958|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996340]
organism-modification
PR:000061460
epidermal growth factor receptor sequence variant T263P, signal peptide removed form (human)
hEGFR/var:T263P/SigPep-
"An epidermal growth factor receptor (human) that has a Pro residue at the position equivalent to Thr-263 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Thr-263, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-1996315]
organism-modification
PR:000061481
epidermal growth factor receptor sequence variant A289T, signal peptide removed form (human)
hEGFR/var:A289T/SigPep-
"An epidermal growth factor receptor (human) that has a Thr residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-1996306]
organism-modification
PR:000061628
epidermal growth factor receptor sequence variant G719A, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G719A/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has an Ala residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:46217|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1177528]
organism-modification
PR:000061782
epidermal growth factor receptor sequence variant A289V, signal peptide removed form (human)
hEGFR/var:A289V/SigPep-
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-1996321]
organism-modification
PR:000061821
epidermal growth factor receptor sequence variant R108K, signal peptide removed form (human)
hEGFR/var:R108K/SigPep-
"An epidermal growth factor receptor (human) that has a Lys residue at the position equivalent to Arg-108 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Arg-108, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1996330]
organism-modification
PR:000061883
epidermal growth factor receptor sequence variant A289T, signal peptide removed phosphorylated 1 (human)
hEGFR/var:A289T/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Thr residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30013|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996341]
organism-modification
PR:000062003
epidermal growth factor receptor sequence variant L858R, signal peptide removed phosphorylated 1 (human)
hEGFR/var:L858R/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Leu-858, CHEBI:29952|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1173211]
organism-modification
PR:000062613
epidermal growth factor receptor sequence variant T790M/L858R, signal peptide removed form (human)
hEGFR/var:(T790M/L858R)/SigPep-
"An epidermal growth factor receptor (human) that has a Met residue at the position equivalent to Thr-790 and an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-1181386]
organism-modification
PR:000062650
epidermal growth factor receptor sequence variant T790M/L858R, signal peptide removed phosphorylated 1 (human)
hEGFR/var:(T790M/L858R)/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Met residue at the position equivalent to Thr-790 and an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1182984]
organism-modification
PR:000062715
epidermal growth factor receptor sequence variant L861Q, signal peptide removed phosphorylated 1 (human)
hEGFR/var:L861Q/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Gln residue at the position equivalent to Leu-861 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Leu-861, CHEBI:30011|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1177541]
organism-modification
PR:000062731
epidermal growth factor receptor sequence variant G719A, signal peptide removed form (human)
hEGFR/var:G719A/SigPep-
"An epidermal growth factor receptor (human) that has an Ala residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-1177532]
organism-modification
PR:000062845
epidermal growth factor receptor sequence variant G598V, signal peptide removed form (human)
hEGFR/var:G598V/SigPep-
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Gly-598 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-598, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-1996314]
organism-modification
PR:000063380
epidermal growth factor receptor sequence variant A289D, signal peptide removed form (human)
hEGFR/var:A289D/SigPep-
"An epidermal growth factor receptor (human) that has an Asp residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-1996327]
organism-modification
PR:000063452
epidermal growth factor receptor sequence variant G598V, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G598V/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Gly-598 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-598, CHEBI:30015|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996339]
organism-modification
PR:000063536
epidermal growth factor receptor sequence variant G719S, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G719S/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Ser residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29999|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1169417]
organism-modification
PR:000063584
epidermal growth factor receptor sequence variant L861Q, signal peptide removed form (human)
hEGFR/var:L861Q/SigPep-
"An epidermal growth factor receptor (human) that has a Gln residue at the position equivalent to Leu-861 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Leu-861, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-1177542]
organism-modification
PR:000063750
epidermal growth factor receptor sequence variant G719C, signal peptide removed form (human)
hEGFR/var:G719C/SigPep-
"An epidermal growth factor receptor (human) that has a Cys residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-1177531]
organism-modification
PR:000063826
epidermal growth factor receptor sequence variant R108K, signal peptide removed phosphorylated 1 (human)
hEGFR/var:R108K/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Lys residue at the position equivalent to Arg-108 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Arg-108, CHEBI:29967|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996338]
organism-modification
PR:000064048
epidermal growth factor receptor sequence variant T263P, signal peptide removed phosphorylated 1 (human)
hEGFR/var:T263P/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Pro residue at the position equivalent to Thr-263 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Thr-263, CHEBI:50342|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996336]
organism-modification
PR:000064466
epidermal growth factor receptor sequence variant L858R, signal peptide removed form (human)
hEGFR/var:L858R/SigPep-
"An epidermal growth factor receptor (human) that has an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Leu-858, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-1173212]
organism-modification
PR:000064533
epidermal growth factor receptor, signal peptide removed phosphorylated 6 (human)
hEGFR/SigPep-/Phos:6
"An epidermal growth factor receptor (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, and Tyr-1197 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864019]
organism-modification
PR:000051027
epidermal growth factor receptor N-glycosylated 1 (human)
hEGFR/NGlyco:1
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-128, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051028
epidermal growth factor receptor N-glycosylated 2 (human)
hEGFR/NGlyco:2
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-175 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-175, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051029
epidermal growth factor receptor N-glycosylated 3 (human)
hEGFR/NGlyco:3
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-352 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-352, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051030
epidermal growth factor receptor N-glycosylated 4 (human)
hEGFR/NGlyco:4
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-361 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-361, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051031
epidermal growth factor receptor N-glycosylated 5 (human)
hEGFR/NGlyco:5
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-413 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-413, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051032
epidermal growth factor receptor N-glycosylated 6 (human)
hEGFR/NGlyco:6
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-444 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-444, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051033
epidermal growth factor receptor N-glycosylated 7 (human)
hEGFR/NGlyco:7
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-528 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-528, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051034
epidermal growth factor receptor N-glycosylated 8 (human)
hEGFR/NGlyco:8
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-56 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P00533-1, Asn-56, MOD:00160~GNO:G78059CC." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051035
epidermal growth factor receptor N-glycosylated 9 (human)
hEGFR/NGlyco:9
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-56 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-56, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051036
epidermal growth factor receptor N-glycosylated 10 (human)
hEGFR/NGlyco:10
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-568 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-568, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000051037
epidermal growth factor receptor N-glycosylated 11 (human)
hEGFR/NGlyco:11
"An epidermal growth factor receptor (human) that has been N-glycosylated at the residue equivalent to Asn-603 of the amino acid sequence represented by UniProtKB:P00533-1, in which the glycan structure is represented by GlyTouCan:G83461WR. Example: UniProtKB:P00533-1, Asn-603, MOD:00160~GNO:G83461WR." [GlyGen:P00533-1, PMID:10731668, PMID:10988252, PRO:DNx]
organism-modification
PR:000066084
epidermal growth factor receptor deaminated 1 (human)
hEGFR/Deam:1
"An epidermal growth factor receptor (human) that has been deaminated on the residue at the position equivalent to Asn-468 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, Asn-468, MOD:00684." [IEDB_epitope:1982581, PRO:DNx]
organism-modification
PR:000083012
epidermal growth factor receptor phosphorylated 1 (human)
hEGFR/Phos:1
"An epidermal growth factor receptor (human) that has been phosphorylated on the residue at the position equivalent to Tyr-1172 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, Tyr-1172, MOD:00048." [IEDB_epitope:2148287, PRO:DNx]
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hEGFR
forms found in complexes
hEGFR
Component
Complexes
PR:000028422
hEGFR/SigPep-
PR:000028451
L1-EGFR trans-heterodimer (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027479
hEGFR/iso:1/SigPep-/Phos:1
UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048
acts_upstream_of_or_within
GO:0034504
protein localization to nucleus
PMID:18789131
located_in
GO:0005634
nucleus
PMID:18789131
PR:000049849
hEGFR/SigPep-/Phos:3
Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
enables
decreased
GO:0004713
protein tyrosine kinase activity
relative to
PR:000049850
hEGFR/SigPep-/UnPhos:3
PMID:10347170
decreased
GO:0005515
protein binding
relative to
PR:000049850
hEGFR/SigPep-/UnPhos:3
PMID:10347170
PR:000049851
hEGFR/SigPep-/Phos:4
Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046
enables
decreased
GO:0004713
protein tyrosine kinase activity
relative to
PR:000049852
hEGFR/SigPep-/UnPhos:4
PMID:10347170
