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Protein Ontology report - RAF proto-oncogene serine/threonine-protein kinase (human)
PR:P04049 - http://purl.obolibrary.org/obo/PR_P04049
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P04049   
  PRO nameRAF proto-oncogene serine/threonine-protein kinase (human) 
  Synonyms
PRO-Short-label: EXACT:hRAF1
Gene-based: RELATED:RAF | RAF1
Other: EXACT:cRaf (human) | proto-oncogene c-RAF (human) | Raf-1 (human)
  Definition"A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human." [PMID:20703093, PRO:KER] 
  PRO Categoryorganism-gene 
  ParentPR:000003244 RAF proto-oncogene serine/threonine-protein kinase
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:9829 RAF1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 58                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P04049
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P04049

RAF proto-oncogene serine/threonine-protein kinase (human)

hRAF1


"A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human." [PMID:20703093, PRO:KER]

Yes

organism-sequence



PR:P04049-1

RAF proto-oncogene serine/threonine-protein kinase isoform 1 (human)

hRAF1/iso:1


"A RAF proto-oncogene serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026210

RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human)

hRAF1/iso:1/Phos:3


"A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 in human. UniProtKB:P04049-1, Ser-259/Ser-621, MOD:00046." [PMID:14688280, PRO:CNA]


organism-modification



PR:000036643

RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)

hRAF1/iso:1/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046." [PMID:15849194, PRO:JAN]

Yes

organism-sequence



PR:P04049-2

RAF proto-oncogene serine/threonine-protein kinase isoform 2 (human)

hRAF1/iso:2


"A RAF proto-oncogene serine/threonine-protein kinase isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000045631

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 1 (human)

hRAF1/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-269 of the amino acid sequence represented by UniProtKB:P04049-1. Example: UniProtKB:P04049-1, Thr-269, MOD:00047." [iPTMnet:P04049, PMID:7477354]


organism-modification



PR:000048997

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 3 (human)

hRAF1/Phos:3


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 259 and 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-259/Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-109786]


organism-modification



PR:000048998

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 4 (human)

hRAF1/Phos:4


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 29, 43, 259, 296, 301, 338, 494, 621 and 642, phosphotyrosine at position 341, and phosphothreonine at position 491 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-29/Ser-43/Ser-259/Ser-296/Ser-301/Ser-338/Ser-494/Ser-621/Ser-642, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-5675193]


organism-modification



PR:000048999

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 5 (human)

hRAF1/Phos:5


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-338 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338, MOD:00046." [PRO:DNx, Reactome:R-HSA-5624469]


organism-modification



PR:000049000

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 6 (human)

hRAF1/Phos:6


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-338, and phosphotyrosine at positions 340 and 341 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338, MOD:00046|Tyr-340/Tyr-341, MOD:00048." [PRO:DNx, Reactome:R-HSA-5624465]


organism-modification



PR:000049001

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 7 (human)

hRAF1/Phos:7


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 338, 494 and 621, phosphotyrosine at position 341, and phosphothreonine at position 491 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-5672664, Reactome:R-HSA-5672665]


organism-modification



PR:000049002

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 8 (human)

hRAF1/Phos:8


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-206028, Reactome:R-HSA-206222]


organism-modification



PR:000049003

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 9 (human)

hRAF1/Phos:9


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Tyr-341, phosphothreonine at position 491, and phosphoserine at positions 494 and 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Tyr-341, MOD:00048|Thr-491, MOD:00047|Ser-494/Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-5675420]


organism-modification



PR:000060294

RAF proto-oncogene serine/threonine-protein kinase sequence variant V263A phosphorylated 1 (human)

hRAF1/var:V263A/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ala residue at the position equivalent to Val-263 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Val-263, CHEBI:46217|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656080]


organism-modification



PR:000060304

RAF proto-oncogene serine/threonine-protein kinase sequence variant N262L phosphorylated 1 (human)

hRAF1/var:N262L/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Leu residue at the position equivalent to Asn-262 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Asn-262, CHEBI:30006|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656101]


organism-modification



PR:000060342

RAF proto-oncogene serine/threonine-protein kinase sequence variant L613V phosphorylated 1 (human)

hRAF1/var:L613V/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Val residue at the position equivalent to Leu-613 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047|Leu-613, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9656035]


organism-modification



PR:000060487

RAF proto-oncogene serine/threonine-protein kinase sequence variant S259T phosphorylated 1 (human)

hRAF1/var:S259T/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Thr residue at the position equivalent to Ser-259 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-259, CHEBI:30013|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656067]


organism-modification



PR:000060534

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261A phosphorylated 1 (human)

hRAF1/var:P261A/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ala residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:46217|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656103]


organism-modification



PR:000060574

RAF proto-oncogene serine/threonine-protein kinase sequence variant G370R phosphorylated 1 (human)

hRAF1/var:G370R/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Gly-370 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Gly-370, CHEBI:29952|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656094]


organism-modification



PR:000060735

RAF proto-oncogene serine/threonine-protein kinase sequence variant R256S phosphorylated 1 (human)

hRAF1/var:R256S/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Ser residue at the position equivalent to Arg-256 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Arg-256, CHEBI:29999|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656056]


organism-modification



PR:000060783

RAF proto-oncogene serine/threonine-protein kinase sequence variant S427G phosphorylated 1 (human)

hRAF1/var:S427G/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Gly residue at the position equivalent to Ser-427 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Ser-427, CHEBI:29947|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656070]


organism-modification



PR:000060875

RAF proto-oncogene serine/threonine-protein kinase sequence variant S427G phosphorylated 2 (human)

hRAF1/var:S427G/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Gly residue at the position equivalent to Ser-427 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Ser-427, CHEBI:29947|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656134]


organism-modification



PR:000060889

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261N phosphorylated 1 (human)

hRAF1/var:P261N/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Asn residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:50347|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656110]


organism-modification



PR:000061147

RAF proto-oncogene serine/threonine-protein kinase sequence variant T260I phosphorylated 1 (human)

hRAF1/var:T260I/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ile residue at the position equivalent to Thr-260 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Thr-260, CHEBI:30009|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656136]


organism-modification



PR:000061178

RAF proto-oncogene serine/threonine-protein kinase sequence variant S259P phosphorylated 1 (human)

hRAF1/var:S259P/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Pro residue at the position equivalent to Ser-259 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-259, CHEBI:50342|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656065]


organism-modification



PR:000061258

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261L phosphorylated 1 (human)

hRAF1/var:P261L/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Leu residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:30006|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656106]


organism-modification



PR:000061438

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261T phosphorylated 1 (human)

hRAF1/var:P261T/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Thr residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:30013|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656115]


organism-modification



PR:000061913

RAF proto-oncogene serine/threonine-protein kinase sequence variant S259P phosphorylated 2 (human)

hRAF1/var:S259P/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Pro residue at the position equivalent to Ser-259 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Ser-259, CHEBI:50342|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656127]


organism-modification



PR:000061916

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261A phosphorylated 2 (human)

hRAF1/var:P261A/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ala residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:46217|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656041]


organism-modification



PR:000062212

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261L phosphorylated 2 (human)

hRAF1/var:P261L/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Leu residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:30006|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656043]


organism-modification



PR:000062247

RAF proto-oncogene serine/threonine-protein kinase sequence variant D486N phosphorylated 1 (human)

hRAF1/var:D486N/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Asn residue at the position equivalent to Asp-486 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Asp-486, CHEBI:50347|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656026]


organism-modification



PR:000062287

RAF proto-oncogene serine/threonine-protein kinase sequence variant D486N phosphorylated 2 (human)

hRAF1/var:D486N/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Asn residue at the position equivalent to Asp-486 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Asp-486, CHEBI:50347|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656088]


organism-modification



PR:000062301

RAF proto-oncogene serine/threonine-protein kinase sequence variant G370R phosphorylated 2 (human)

hRAF1/var:G370R/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Gly-370 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Gly-370, CHEBI:29952|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656031]


organism-modification



PR:000062538

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261S phosphorylated 1 (human)

hRAF1/var:P261S/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Ser residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:29999|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656113]


organism-modification



PR:000062644

RAF proto-oncogene serine/threonine-protein kinase sequence variant D486G phosphorylated 1 (human)

hRAF1/var:D486G/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Gly residue at the position equivalent to Asp-486 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Asp-486, CHEBI:29947|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656085]


organism-modification



PR:000062694

RAF proto-oncogene serine/threonine-protein kinase sequence variant L613V phosphorylated 2 (human)

hRAF1/var:L613V/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Val residue at the position equivalent to Leu-613 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Leu-613, CHEBI:30015|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656098]


organism-modification



PR:000062754

RAF proto-oncogene serine/threonine-protein kinase sequence variant S257L phosphorylated 1 (human)

hRAF1/var:S257L/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Leu residue at the position equivalent to Ser-257 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Ser-257, CHEBI:30006|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656121]


organism-modification



PR:000062783

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261S phosphorylated 2 (human)

hRAF1/var:P261S/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Ser residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:29999|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656050]


organism-modification



PR:000062809

RAF proto-oncogene serine/threonine-protein kinase sequence variant T491R phosphorylated 1 (human)

hRAF1/var:T491R/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Thr-491 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9656017]


organism-modification



PR:000062928

RAF proto-oncogene serine/threonine-protein kinase sequence variant T260I phosphorylated 2 (human)

hRAF1/var:T260I/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ile residue at the position equivalent to Thr-260 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Thr-260, CHEBI:30009|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656074]


organism-modification



PR:000063034

RAF proto-oncogene serine/threonine-protein kinase sequence variant V263A phosphorylated 2 (human)

hRAF1/var:V263A/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ala residue at the position equivalent to Val-263 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Val-263, CHEBI:46217|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656148]


organism-modification



PR:000063172

RAF proto-oncogene serine/threonine-protein kinase sequence variant T491R phosphorylated 2 (human)

hRAF1/var:T491R/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Thr-491 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Thr-491, CHEBI:29952|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656145]


organism-modification



PR:000063187

RAF proto-oncogene serine/threonine-protein kinase sequence variant S257L phosphorylated 2 (human)

hRAF1/var:S257L/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Leu residue at the position equivalent to Ser-257 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-257, CHEBI:30006|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656058]


organism-modification



PR:000063405

RAF proto-oncogene serine/threonine-protein kinase sequence variant D486G phosphorylated 2 (human)

hRAF1/var:D486G/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Gly residue at the position equivalent to Asp-486 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Asp-486, CHEBI:29947|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656023]


organism-modification



PR:000063408

RAF proto-oncogene serine/threonine-protein kinase sequence variant G361A phosphorylated 1 (human)

hRAF1/var:G361A/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ala residue at the position equivalent to Gly-361 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Gly-361, CHEBI:46217|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656092]


organism-modification



PR:000063432

RAF proto-oncogene serine/threonine-protein kinase sequence variant R256S phosphorylated 2 (human)

hRAF1/var:R256S/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Ser residue at the position equivalent to Arg-256 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Arg-256, CHEBI:29999|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656119]


organism-modification



PR:000063451

RAF proto-oncogene serine/threonine-protein kinase sequence variant T491I phosphorylated 1 (human)

hRAF1/var:T491I/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ile residue at the position equivalent to Thr-491 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, CHEBI:30009." [PRO:DNx, Reactome:R-HSA-9656019]


organism-modification



PR:000063537

RAF proto-oncogene serine/threonine-protein kinase sequence variant T260R phosphorylated 1 (human)

hRAF1/var:T260R/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Thr-260 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Thr-260, CHEBI:29952|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656139]


organism-modification



PR:000063579

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261T phosphorylated 2 (human)

hRAF1/var:P261T/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Thr residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:30013|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656053]


organism-modification



PR:000063663

RAF proto-oncogene serine/threonine-protein kinase sequence variant S259T phosphorylated 2 (human)

hRAF1/var:S259T/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Thr residue at the position equivalent to Ser-259 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Ser-259, CHEBI:30013|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656130]


organism-modification



PR:000063974

RAF proto-oncogene serine/threonine-protein kinase sequence variant T491I phosphorylated 2 (human)

hRAF1/var:T491I/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ile residue at the position equivalent to Thr-491 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Thr-491, CHEBI:30009|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656143]


organism-modification



PR:000064065

RAF proto-oncogene serine/threonine-protein kinase sequence variant T260R phosphorylated 2 (human)

hRAF1/var:T260R/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Thr-260 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Thr-260, CHEBI:29952|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656077]


organism-modification



PR:000064095

RAF proto-oncogene serine/threonine-protein kinase sequence variant P261N phosphorylated 2 (human)

hRAF1/var:P261N/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Asn residue at the position equivalent to Pro-261 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Pro-261, CHEBI:50347|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656047]


organism-modification



PR:000064135

RAF proto-oncogene serine/threonine-protein kinase phosphotyrosine form (human)

hRAF1/PhosTyr+


"A RAF proto-oncogene serine/threonine-protein kinase (human) that includes at least one phosphorylated tyrosine. UniProtKB:P04049, MOD:00048." [PRO:DNx, Reactome:R-HSA-9732747]


organism-modification



PR:000064182

RAF proto-oncogene serine/threonine-protein kinase sequence variant S259F phosphorylated 1 (human)

hRAF1/var:S259F/Phos:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Phe residue at the position equivalent to Ser-259 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Ser-259, CHEBI:29997|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656124]


organism-modification



PR:000064238

RAF proto-oncogene serine/threonine-protein kinase sequence variant G361A phosphorylated 2 (human)

hRAF1/var:G361A/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ala residue at the position equivalent to Gly-361 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Gly-361, CHEBI:46217|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656029]


organism-modification



PR:000064242

RAF proto-oncogene serine/threonine-protein kinase sequence variant N262L phosphorylated 2 (human)

hRAF1/var:N262L/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Leu residue at the position equivalent to Asn-262 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Asn-262, CHEBI:30006|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656037]


organism-modification



PR:000064564

RAF proto-oncogene serine/threonine-protein kinase sequence variant S259F phosphorylated 2 (human)

hRAF1/var:S259F/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has a Phe residue at the position equivalent to Ser-259 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-259, CHEBI:29997|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656062]


organism-modification



PR:000065842

RAF proto-oncogene serine/threonine-protein kinase phosphorylated 2 (human)

hRAF1/Phos:2


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-233 of the amino acid sequence represented by UniProtKB:P04049-1. Example: UniProtKB:P04049-1, Ser-233, MOD:00046." [IEDB_epitope:912120, PRO:DNx]


organism-modification



PR:000070181

RAF proto-oncogene serine/threonine-protein kinase deaminated 1 (human)

hRAF1/Deam:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been deaminated on the residue at the position equivalent to Asn-13 of the amino acid sequence represented by UniProtKB:P04049-1. Example: UniProtKB:P04049-1, Asn-13, MOD:00684." [IEDB_epitope:860660, PRO:DNx]


organism-modification



PR:000078506

RAF proto-oncogene serine/threonine-protein kinase cysteinylated 1 (human)

hRAF1/Cyst:1


"A RAF proto-oncogene serine/threonine-protein kinase (human) that has been cysteinylated on the residue at the position equivalent to Cys-27 of the amino acid sequence represented by UniProtKB:P04049-1. Example: UniProtKB:P04049-1, Cys-27, MOD:00765." [IEDB_epitope:1591920, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036643 hRAF1/iso:1/Phos:2
UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046
acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:15849194
enablesGO:0004674 protein serine/threonine kinase activity PMID:15849194
GO:0005515 protein binding PMID:15849194
located_inGO:0005741 mitochondrial outer membrane PMID:15849194
PR:P04049 hRAF1 acts_upstream_of_or_withinGO:0032877 positive regulation of DNA endoreduplication PMID:20703093
enablesGO:0005515 protein binding with PR:O60566 BUB1B PMID:20703093