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Protein Ontology report - cellular tumor antigen p53 isoform 1 (human)
PR:P04637-1 -
http://purl.obolibrary.org/obo/PR_P04637-1
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P04637-1
PRO name
cellular tumor antigen p53 isoform 1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hTP53/iso:1
Definition
"A cellular tumor antigen p53 isoform 1 that is encoded in the genome of human." [
PMID:17671183
,
PMID:19252416
, PRO:KER]
PRO Category
organism-sequence
Parent
PR:000003036
cellular tumor antigen p53 isoform 1
PR:P04637
cellular tumor antigen p53 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
22
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P04637-1
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-sequence
PR:P04637-1
cellular tumor antigen p53 isoform 1 (human)
hTP53/iso:1
"A cellular tumor antigen p53 isoform 1 that is encoded in the genome of human." [PMID:17671183, PMID:19252416, PRO:KER]
Yes
organism-modification
PR:000027764
cellular tumor antigen p53 isoform 1 phosphorylated 3 (human)
hTP53/iso:1/Phos:3
"A cellular tumor antigen p53 isoform 1 phosphorylated 3 in human. UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:DAN, PRO:PD]
organism-modification
PR:000027766
cellular tumor antigen p53 isoform 1 dimethylated 1 (human)
hTP53/iso:1/Me2:1
"A cellular tumor antigen p53 isoform 1 dimethylated 1 in human. UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD]
Yes
organism-modification
PR:000027768
cellular tumor antigen p53 isoform 1 phosphorylated 4 (human)
hTP53/iso:1/Phos:4
"A cellular tumor antigen p53 isoform 1 phosphorylated 4 in human. UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD]
organism-modification
PR:000027770
cellular tumor antigen p53 isoform 1 phosphorylated 5 (human)
hTP53/iso:1/Phos:5
"A cellular tumor antigen p53 isoform 1 phosphorylated 5 in human. UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD]
organism-modification
PR:000027772
cellular tumor antigen p53 isoform 1 phosphorylated 6 (human)
hTP53/iso:1/Phos:6
"A cellular tumor antigen p53 isoform 1 phosphorylated 6 in human. UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD]
organism-modification
PR:000027774
cellular tumor antigen p53 isoform 1 acetylated 1 (human)
hTP53/iso:1/Ac:1
"A cellular tumor antigen p53 isoform 1 acetylated 1 in human. UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD]
Yes
organism-modification
PR:000027806
cellular tumor antigen p53 isoform 1 ubiquitinated 1 (human)
hTP53/iso:1/Ubiq:1
"A cellular tumor antigen p53 isoform 1 ubiquitinated 1 in human. UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD]
organism-modification
PR:000027808
cellular tumor antigen p53 isoform 1 methylated 3 (human)
hTP53/iso:1/Me:3
"A cellular tumor antigen p53 isoform 1 methylated 3 in human. This modification promotes p53 stability and inhibits Smyd2 mediated p53 methylation at Lys-370. UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD]
Yes
organism-modification
PR:000027810
cellular tumor antigen p53 isoform 1 methylated 4 (human)
hTP53/iso:1/Me:4
"A cellular tumor antigen p53 isoform 1 methylated 4 in human. UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD]
Yes
organism-modification
PR:000027812
cellular tumor antigen p53 isoform 1 acetylated 2 (human)
hTP53/iso:1/Ac:2
"A cellular tumor antigen p53 isoform 1 acetylated 2 in human. UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD]
Yes
organism-modification
PR:000027814
cellular tumor antigen p53 isoform 1 phosphorylated 12 (human)
hTP53/iso:1/Phos:12
"A cellular tumor antigen p53 isoform 1 phosphorylated 12 in human. UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD]
Yes
organism-modification
PR:000027827
cellular tumor antigen p53 isoform 1 dimethylated 2 (human)
hTP53/iso:1/Me2:2
"A cellular tumor antigen p53 isoform 1 dimethylated 2 in human. UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD]
organism-modification
PR:000027829
cellular tumor antigen p53 isoform 1 phosphorylated 7 (human)
hTP53/iso:1/Phos:7
"A cellular tumor antigen p53 isoform 1 phosphorylated 7 in human. UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD]
organism-modification
PR:000027831
cellular tumor antigen p53 isoform 1 phosphorylated 8 (human)
hTP53/iso:1/Phos:8
"A cellular tumor antigen p53 isoform 1 phosphorylated 8 in human. UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD]
organism-modification
PR:000027833
cellular tumor antigen p53 isoform 1 phosphorylated 9 (human)
hTP53/iso:1/Phos:9
"A cellular tumor antigen p53 isoform 1 phosphorylated 9 in human. UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD]
Yes
organism-modification
PR:000027835
cellular tumor antigen p53 isoform 1 O-glycosylated 1 (human)
hTP53/iso:1/OGlyco:1
"A cellular tumor antigen p53 isoform 1 O-glycosylated 1 in human. UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:PD]
organism-modification
PR:000027837
cellular tumor antigen p53 isoform 1 phosphorylated 10 (human)
hTP53/iso:1/Phos:10
"A cellular tumor antigen p53 isoform 1 phosphorylated 10 in human. UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD]
organism-modification
PR:000027839
cellular tumor antigen p53 isoform 1 phosphorylated 11 (human)
hTP53/iso:1/Phos:11
"A cellular tumor antigen p53 isoform 1 phosphorylated 11 in human. UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD]
Yes
organism-modification
PR:000027841
cellular tumor antigen p53 isoform 1 sumoylated 1 (human)
hTP53/iso:1/Sumo:1
"A cellular tumor antigen p53 isoform 1 sumoylated 1 in human. UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD]
Yes
organism-modification
PR:000027846
cellular tumor antigen p53 isoform 1 unmodified form (human)
hTP53/iso:1/UnMod
"A cellular tumor antigen p53 isoform 1 unmodified form in human." [PMID:19339993, PRO:CNA]
Yes
organism-modification
PR:000035446
cellular tumor antigen p53 isoform 1 phosphorylated 1 (human)
hTP53/iso:1/Phos:1
"A cellular tumor antigen p53 isoform 1 phosphorylated 1 in human. UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:22099307, PRO:KER]
Yes
organism-modification
PR:000036624
cellular tumor antigen p53 isoform 1 phosphorylated 2 (human)
hTP53/iso:1/Phos:2
"A cellular tumor antigen p53 isoform 1 phosphorylated 2 in human. UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL]
Yes
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hTP53/iso:1
forms found in complexes
hTP53/iso:1
Component
Complexes
PR:000027841
hTP53/iso:1/Sumo:1
PR:000027844
p53 complex sumoylated 1 (human)
PR:000027846
hTP53/iso:1/UnMod
PR:000027844
p53 complex sumoylated 1 (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027766
hTP53/iso:1/Me2:1
UniProtKB:P04637-1, Lys-382, MOD:00084
enables
GO:0005515
protein binding
with
PR:Q12888
53BP1 (human)
PMID:18840612
PR:000027774
hTP53/iso:1/Ac:1
UniProtKB:P04637-1, Lys-120, MOD:00064
acts_upstream_of_or_within
GO:0043065
positive regulation of apoptotic process
PMID:17189187
PR:000027808
hTP53/iso:1/Me:3
UniProtKB:P04637-1, Lys-372, MOD:00663
acts_upstream_of_or_within
GO:0045893
positive regulation of DNA-templated transcription
PMID:15525938
located_in
GO:0005634
nucleus
PMID:15525938
PR:000027810
hTP53/iso:1/Me:4
UniProtKB:P04637-1, Lys-370, MOD:00663
acts_upstream_of_or_within
GO:0045892
negative regulation of DNA-templated transcription
PMID:17108971
PR:000027812
hTP53/iso:1/Ac:2
UniProtKB:P04637-1, Lys-382, MOD:00064
acts_upstream_of_or_within
GO:0045893
positive regulation of DNA-templated transcription
PMID:20228809
PR:000027814
hTP53/iso:1/Phos:12
UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046
acts_upstream_of_or_within
GO:0045893
positive regulation of DNA-templated transcription
PMID:21317932
located_in
GO:0005634
nucleus
PMID:21317932
PR:000027833
hTP53/iso:1/Phos:9
UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046
acts_upstream_of_or_within
GO:0010468
regulation of gene expression
PMID:14712210
PR:000027839
hTP53/iso:1/Phos:11
UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047
acts_upstream_of_or_within
GO:0010629
negative regulation of gene expression
PMID:20959462
PR:000035446
hTP53/iso:1/Phos:1
UniProtKB:P04637-1, Ser-15, MOD:00046
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:11602639
located_in
GO:0005634
nucleus
PMID:11602639
PR:000036624
hTP53/iso:1/Phos:2
UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:15642743
enables
GO:0005515
protein binding
with
PR:000003109
MAPK p38 active form
PMID:15642743
PR:P04637-1
hTP53/iso:1
enables
GO:0005515
protein binding
with
PR:O43683
BUB1
PMID:17671183
GO:0005515
protein binding
with
PR:O60566
BUB1B
PMID:17671183
