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Protein Ontology report - thrombospondin-1 (human)
PR:P07996 -
http://purl.obolibrary.org/obo/PR_P07996
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:P07996
PRO name
thrombospondin-1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hTHBS1
Gene-based
:
RELATED:
THBS1 | TSP | TSP1
Other
:
EXACT:
glycoprotein G (human)
Definition
"A thrombospondin-1 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P07996
]
PRO Category
organism-gene
Parent
PR:000000129
thrombospondin-1
PR:000029067
Homo sapiens protein
Gene Template
HGNC:11785
THBS1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
2
Modification
0
Organism-Modification
16
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P07996
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P07996
thrombospondin-1 (human)
hTHBS1
"A thrombospondin-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07996]
organism-sequence
PR:P07996-1
thrombospondin-1 isoform 1 (human)
hTHBS1/iso:1
"A thrombospondin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000026338
thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
"A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]
Yes
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
organism-modification
PR:000028966
thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2
"A thrombospondin-1 isoform 1 cleaved 2 in human. UniProtKB:P07996-1, 19-311." [PRO:DAN]
organism-sequence
PR:P07996-2
thrombospondin-1 isoform 2 (human)
hTHBS1/iso:2
"A thrombospondin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07996-2." [PRO:DNx, UniProtKB:P07996]
organism-modification
PR:000028410
thrombospondin-1, signal peptide removed form (human)
hTHBS1/SigPep-
"A thrombospondin-1, signal peptide removed form in human. Example: UniProtKB:P07996-1, 19-1170." [PRO:DNx]
Yes
Yes
organism-modification
PR:000026338
thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
"A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]
Yes
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
organism-modification
PR:000064777
thrombospondin-1, signal peptide removed O-glycosylserine form (human)
hTHBS1/SigPep-/OGlycoSer+
"A thrombospondin-1 (human) that has had the signal peptide removed and that includes at least one O-glycosylated serine. Example: UniProtKB:P07996-1, 19-1170, MOD:00002." [PRO:DNx, Reactome:R-HSA-5172997]
organism-modification
PR:000060409
thrombospondin-1, signal peptide removed fucosylserine form (human)
hTHBS1/SigPep-/FucSer+
"A thrombospondin-1 (human) that has had the signal peptide removed and that includes at least one fucosylserine. Example: UniProtKB:P07996-1, 19-1170, MOD:00812." [PRO:DNx, Reactome:R-HSA-5173278]
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
organism-modification
PR:000054414
thrombospondin-1 N-glycosylated 1 (human)
hTHBS1/NGlyco:1
"A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G09197ZW. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G09197ZW." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
organism-modification
PR:000054415
thrombospondin-1 N-glycosylated 2 (human)
hTHBS1/NGlyco:2
"A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G16175ZV. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G16175ZV." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
organism-modification
PR:000054416
thrombospondin-1 N-glycosylated 3 (human)
hTHBS1/NGlyco:3
"A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G27126ED. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G27126ED." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
organism-modification
PR:000054418
thrombospondin-1 N-glycosylated 5 (human)
hTHBS1/NGlyco:5
"A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G59626AS." [GlyGen:P07996-1, PMID:23345538, PMID:29671580, PRO:DNx]
organism-modification
PR:000054419
thrombospondin-1 N-glycosylated 6 (human)
hTHBS1/NGlyco:6
"A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-360 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G87051GH. Example: UniProtKB:P07996-1, Asn-360, MOD:00160~GNO:G87051GH." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
organism-modification
PR:000060409
thrombospondin-1, signal peptide removed fucosylserine form (human)
hTHBS1/SigPep-/FucSer+
"A thrombospondin-1 (human) that has had the signal peptide removed and that includes at least one fucosylserine. Example: UniProtKB:P07996-1, 19-1170, MOD:00812." [PRO:DNx, Reactome:R-HSA-5173278]
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
organism-modification
PR:000064777
thrombospondin-1, signal peptide removed O-glycosylserine form (human)
hTHBS1/SigPep-/OGlycoSer+
"A thrombospondin-1 (human) that has had the signal peptide removed and that includes at least one O-glycosylated serine. Example: UniProtKB:P07996-1, 19-1170, MOD:00002." [PRO:DNx, Reactome:R-HSA-5172997]
organism-modification
PR:000060409
thrombospondin-1, signal peptide removed fucosylserine form (human)
hTHBS1/SigPep-/FucSer+
"A thrombospondin-1 (human) that has had the signal peptide removed and that includes at least one fucosylserine. Example: UniProtKB:P07996-1, 19-1170, MOD:00812." [PRO:DNx, Reactome:R-HSA-5173278]
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
organism-modification
PR:000073784
thrombospondin-1 methylated 1 (human)
hTHBS1/Me:1
"A thrombospondin-1 (human) that has been methylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:P07996-1. Example: UniProtKB:P07996-1, Cys-270, MOD:00660." [IEDB_epitope:1023271, PRO:DNx]
organism-modification
PR:000076437
thrombospondin-1 deaminated 1 (human)
hTHBS1/Deam:1
"A thrombospondin-1 (human) that has been deaminated on the residue at the position equivalent to Gln-209 of the amino acid sequence represented by UniProtKB:P07996-1. Example: UniProtKB:P07996-1, Gln-209, MOD:00685." [IEDB_epitope:1999117, PRO:DNx]
organism-modification
PR:000079618
thrombospondin-1 cysteinylated 1 (human)
hTHBS1/Cyst:1
"A thrombospondin-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-874 of the amino acid sequence represented by UniProtKB:P07996-1. Example: UniProtKB:P07996-1, Cys-874, MOD:00765." [IEDB_epitope:1562937, PRO:DNx]
organism-modification
PR:000079709
thrombospondin-1 cysteinylated 2 (human)
hTHBS1/Cyst:2
"A thrombospondin-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-754 of the amino acid sequence represented by UniProtKB:P07996-1. Example: UniProtKB:P07996-1, Cys-754, MOD:00765." [IEDB_epitope:1562921, IEDB_epitope:1581350, PRO:DNx]
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hTHBS1
forms found in complexes
hTHBS1
Component
Complexes
PR:000028410
hTHBS1/SigPep-
PR:000028445
integrin alphaIIbbeta3:thrombospondin 1 (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026338
hTHBS1/iso:1/SigPep-
UniProtKB:P07996-1, 19-1170
enables
GO:0004866
endopeptidase inhibitor activity
PMID:8751720
located_in
GO:0005615
extracellular space
PMID:15662972
PR:000028410
hTHBS1/SigPep-
Example: UniProtKB:P07996-1, 19-1170
located_in
GO:0005615
extracellular space
PMID:15662972
PR:000036488
hTHBS1/iso:1/SigPep-/Glyco:1
UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813
enables
GO:0005515
protein binding
with
PR:000028966
hTHBS1/iso:1/Clv:2
PMID:3305519
GO:0050431
transforming growth factor beta binding
PMID:15342643
