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Protein Ontology report - pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
PR:P08559 -
http://purl.obolibrary.org/obo/PR_P08559
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:P08559
PRO name
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
Synonyms
PRO-Short-label
:
EXACT:
hPDHA1
Gene-based
:
RELATED:
PDHA1 | PHE1A
Other
:
EXACT:
PDHE1-A type I (human)
Definition
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial that is encoded in the genome of human." [PRO:DNx,
UniProtKB:P08559
]
PRO Category
organism-gene
Parent
PR:000012493
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
PR:000029067
Homo sapiens protein
Gene Template
HGNC:8806
PDHA1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
4
Modification
0
Organism-Modification
7
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P08559
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P08559
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
hPDHA1
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08559]
organism-sequence
PR:P08559-1
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1 (human)
hPDHA1/iso:1
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
organism-sequence
PR:P08559-2
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform h2 (human)
hPDHA1/iso:h2
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08559-2." [PRO:DNx, UniProtKB:P08559]
organism-sequence
PR:P08559-3
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform h3 (human)
hPDHA1/iso:h3
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08559-3." [PRO:DNx, UniProtKB:P08559]
organism-sequence
PR:P08559-4
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform h4 (human)
hPDHA1/iso:h4
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08559-4." [PRO:DNx, UniProtKB:P08559]
organism-modification
PR:000044835
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
hPDHA1/TransPep-
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form in human. Example: UniProtKB:P08559-1, 30-390." [PMID:23146587, PRO:CNA]
organism-modification
PR:000044826
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 1 (human)
hPDHA1/TransPep-/Phos:1
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-232 of the amino acid sequence represented by UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
Yes
organism-modification
PR:000044827
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 2 (human)
hPDHA1/TransPep-/Phos:2
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-293 of the amino acid sequence represented by UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
Yes
organism-modification
PR:000044828
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)
hPDHA1/TransPep-/Phos:3
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
Yes
union
PR:000044829
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial inactive (human)
hPDHA1/TransPep-/Phos:[123]
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) whose pyruvate dehydrogenase activity has been inhibited." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
Yes
organism-modification
PR:000044826
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 1 (human)
hPDHA1/TransPep-/Phos:1
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-232 of the amino acid sequence represented by UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
organism-modification
PR:000044827
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 2 (human)
hPDHA1/TransPep-/Phos:2
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-293 of the amino acid sequence represented by UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
organism-modification
PR:000044828
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)
hPDHA1/TransPep-/Phos:3
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
organism-modification
PR:000044832
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 4 (human)
hPDHA1/TransPep-/Phos:4
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-293 and Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293/Ser-300, MOD:00046." [CPTAC:breast_cancer_dataset, PRO:AEL]
organism-modification
PR:000044833
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 5 (human)
hPDHA1/TransPep-/Phos:5
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue equivalent to Ser-293, and that lacks phosphorylation on the residue at the position equivalent to Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046|Ser-300, PR:000026291." [CPTAC:breast_cancer_dataset, PRO:AEL]
organism-modification
PR:000044834
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 6 (human)
hPDHA1/TransPep-/Phos:6
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that lacks phosphorylation on the residue at the position equivalent to Ser-293, and that has been phosphorylated on the residue at the position equivalent to Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, PR:000026291|Ser-300, MOD:00046." [CPTAC:breast_cancer_dataset, PRO:AEL]
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000044826
hPDHA1/TransPep-/Phos:1
Example: UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046
enables
NOT
GO:0004739
pyruvate dehydrogenase (acetyl-transferring) activity
PMID:11092882
;
PMID:7782287
PR:000044827
hPDHA1/TransPep-/Phos:2
Example: UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046
enables
NOT
GO:0004739
pyruvate dehydrogenase (acetyl-transferring) activity
PMID:11092882
;
PMID:7782287
PR:000044828
hPDHA1/TransPep-/Phos:3
Example: UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046
enables
NOT
GO:0004739
pyruvate dehydrogenase (acetyl-transferring) activity
PMID:11092882
;
PMID:7782287
PR:000044829
hPDHA1/TransPep-/Phos:[123]
enables
NOT
GO:0004739
pyruvate dehydrogenase (acetyl-transferring) activity
PMID:11092882
;
PMID:7782287
