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Protein Ontology report - platelet-derived growth factor receptor beta (human)
PR:P09619 - http://purl.obolibrary.org/obo/PR_P09619
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P09619   
  PRO nameplatelet-derived growth factor receptor beta (human) 
  Synonyms
PRO-Short-label: EXACT:hPDGFRB
Gene-based: RELATED:PDGFR | PDGFR1 | PDGFRB
Other: EXACT:beta platelet-derived growth factor receptor (human) | beta-type platelet-derived growth factor receptor (human) | CD140 antigen-like family member B (human) | CD140b (human) | PDGF-R-beta (human) | PDGFR-1 (human) | PDGFR-beta (human) | platelet-derived growth factor receptor 1 (human)
  Definition"A beta-type platelet-derived growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P09619] 
  PRO Categoryorganism-gene 
  ParentPR:000002035 beta-type platelet-derived growth factor receptor
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:8804 PDGFRB (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P09619
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P09619
platelet-derived growth factor receptor beta (human)
hPDGFRB
"A beta-type platelet-derived growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P09619]

organism-sequence


PR:P09619-1
platelet-derived growth factor receptor beta isoform 1 (human)
hPDGFRB/iso:1
"A beta-type platelet-derived growth factor receptor isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:P09619-2
platelet-derived growth factor receptor beta isoform h2 (human)
hPDGFRB/iso:h2
"A platelet-derived growth factor receptor beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09619-2." [PRO:DNx, UniProtKB:P09619]

organism-modification


PR:000048725
platelet-derived growth factor receptor beta, signal peptide removed form (human)
hPDGFRB/SigPep-
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed. UniProtKB:P09619, 33-1106." [PRO:DNx, Reactome:R-HSA-186767]

organism-modification


PR:000048726
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 1 (human)
hPDGFRB/SigPep-/Phos:1
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 579, 581, 716, 740, 751, 763, 771, 775, 778, 857, 1009 and 1021 of the amino acid sequence represented by UniProtKB:P09619. UniProtKB:P09619, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009/Tyr-1021, MOD:00048." [PRO:DNx, Reactome:R-HSA-186803]

organism-modification


PR:000049846
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 2 (human)
hPDGFRB/SigPep-/Phos:2
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048." [PMID:1653029, PMID:9642269, PRO:KER]
Yes
organism-modification


PR:000049847
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 3 (human)
hPDGFRB/SigPep-/Phos:3
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on residues at positions equivalent to Tyr-857 and Ser-1104 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046." [PMID:15271984, PMID:15994317, PRO:KER]
Yes
organism-modification


PR:000049848
platelet-derived growth factor receptor beta, signal peptide removed unphosphorylated 2 (human)
hPDGFRB/SigPep-/UnPhos:2
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that lacks phosphorylation on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291." [PMID:1653029, PMID:9642269, PRO:KER]
Yes
organism-modification


PR:000064602
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 4 (human)
hPDGFRB/SigPep-/Phos:4
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-579, Tyr-581, Tyr-716, Tyr-740, Tyr-751, Tyr-763, Tyr-771, Tyr-775, Tyr-778, Tyr-857, and Tyr-1009 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864039]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000049846 hPDGFRB/SigPep-/Phos:2
Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048		 acts_upstream_of_or_withinincreased GO:0018108 peptidyl-tyrosine phosphorylation relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 PMID:1653029; PMID:9642269
enablesGO:0004713 protein tyrosine kinase activity PMID:15994317; PMID:9642269
increased GO:0005515 protein binding relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 PMID:1653029
PR:000049847 hPDGFRB/SigPep-/Phos:3
Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046		 acts_upstream_of_or_withindecreased GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
decreased GO:0005515 protein binding relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
PR:000049848 hPDGFRB/SigPep-/UnPhos:2
Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291		 acts_upstream_of_or_withinGO:0038083 peptidyl-tyrosine autophosphorylation PMID:9642269