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Protein Ontology report - apoptosis regulator Bcl-2 (human)
PR:P10415 - http://purl.obolibrary.org/obo/PR_P10415
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P10415   
  PRO nameapoptosis regulator Bcl-2 (human) 
  Synonyms
PRO-Short-label: EXACT:hBCL2
Gene-based: RELATED:BCL2
  Definition"An apoptosis regulator Bcl-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10415] 
  PRO Categoryorganism-gene 
  ParentPR:000002307 apoptosis regulator Bcl-2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:990 BCL2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P10415
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P10415
apoptosis regulator Bcl-2 (human)
hBCL2
"An apoptosis regulator Bcl-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10415]

organism-sequence


PR:P10415-1
apoptosis regulator Bcl-2 isoform Alpha (human)
hBCL2/iso:Alpha
"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]
Yes
organism-modification


PR:000027461
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]
Yes
organism-modification


PR:000027463
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]
Yes
organism-modification


PR:000027465
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]
Yes
organism-modification


PR:000027467
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]
Yes
organism-sequence


PR:P10415-2
apoptosis regulator Bcl-2 isoform Beta (human)
hBCL2/iso:Beta
"An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of human." [PRO:JAN, PRO:SY]

organism-modification


PR:000070038
apoptosis regulator Bcl-2 methylated 1 (human)
hBCL2/Me:1
"An apoptosis regulator Bcl-2 (human) that has been methylated on the residue at the position equivalent to Cys-229 of the amino acid sequence represented by UniProtKB:P10415-1. Example: UniProtKB:P10415-1, Cys-229, MOD:00660." [IEDB_epitope:1032350, PRO:DNx]

organism-modification


PR:000082889
apoptosis regulator Bcl-2 cysteinylated 1 (human)
hBCL2/Cyst:1
"An apoptosis regulator Bcl-2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-158 of the amino acid sequence represented by UniProtKB:P10415-1. Example: UniProtKB:P10415-1, Cys-158, MOD:00765." [IEDB_epitope:1569724, PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027461 hBCL2/iso:1/Phos:2
UniProtKB:P10415-1, Thr-74, MOD:00047		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:12039864
PR:000027463 hBCL2/iso:1/Phos:3
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046		 acts_upstream_of_or_withinGO:0016239 positive regulation of macroautophagy PMID:18570871; PMID:19029119
enablesNOT GO:0005515 protein binding with PR:Q14457 BECN1 PMID:18570871; PMID:19029119
PR:000027465 hBCL2/iso:1/Phos:4
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046		 acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15703383
PR:000027467 hBCL2/iso:1/Phos:5
UniProtKB:P10415-1, Thr-56, MOD:00047		 acts_upstream_of_or_withinGO:0045839 negative regulation of mitotic nuclear division PMID:10766756
PR:P10415-1 hBCL2/iso:Alpha acts_upstream_of_or_withinGO:0070885 negative regulation of calcineurin-NFAT signaling cascade PMID:9109491
enablesGO:0005515 protein binding with PR:P63328 calcineurin A alpha (mouse) PMID:9109491
GO:0005515 protein binding with PR:Q07813 Bax PMID:9109491
located_inGO:0005886 plasma membrane PMID:9109491