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Protein Ontology report - catenin beta-1 isoform 1 (human)
PR:P35222-1 - http://purl.obolibrary.org/obo/PR_P35222-1
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P35222-1   
  PRO namecatenin beta-1 isoform 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hCTNNB1/iso:1
  Definition"A catenin beta-1 isoform 1 that is encoded in the genome of human." [PRO:JAN] 
  CommentRequested by=PubChem. 
  PRO Categoryorganism-sequence 
  ParentPR:000002319 catenin beta-1 isoform 1
PR:P35222 catenin beta-1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 23                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P35222-1
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:P35222-1
catenin beta-1 isoform 1 (human)
hCTNNB1/iso:1
"A catenin beta-1 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000028553
catenin beta-1 isoform 1 acetylated 1 (human)
hCTNNB1/iso:1/Ac:1
"A catenin beta-1 isoform 1 acetylated 1 in human. UniProtKB:P35222-1, Lys-345, MOD:00064." [KAT:P35222, PMID:15060161, PRO:DAN, PRO:PD]

organism-modification


PR:000028794
catenin beta-1 isoform 1 acetylated 2 (human)
hCTNNB1/iso:1/Ac:2
"A catenin beta-1 isoform 1 acetylated 2 in human. UniProtKB:P35222-1, Lys-19/Lys-49, MOD:00064." [PMID:18987336, PRO:PD]

organism-modification


PR:000030192
catenin beta-1 isoform 1 phosphorylated 1 (human)
hCTNNB1/iso:1/Phos:1
"A catenin beta-1 isoform 1 phosphorylated 1 in human. Phosphorylation at Ser-663 is found in many human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation. Ser-675 can be phosphorylated by either PAK1 or PKA. UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046." [PMID:22369945, PRO:IC]
Yes
organism-modification


PR:000035770
catenin beta-1 isoform 1 phosphorylated 2 (human)
hCTNNB1/iso:1/Phos:2
"A catenin beta-1 isoform 1 phosphorylated 2 in human. Tyr-64 is the major phosphorylation site for PTK6. UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)." [PMID:20026641, PRO:IC]
Yes
organism-modification


PR:000035772
catenin beta-1 isoform 1 phosphorylated 3 (human)
hCTNNB1/iso:1/Phos:3
"A catenin beta-1 isoform 1 phosphorylated 3 in human. Phosphorylation at Ser-45 is needed for the other sites to be phosphorylated. UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:12000790, PMID:16199882, PRO:IC]
Yes
organism-modification


PR:000035774
catenin beta-1 isoform 1 phosphorylated 4 (human)
hCTNNB1/iso:1/Phos:4
"A catenin beta-1 isoform 1 phosphorylated 4 in human. UniProtKB:P35222-1, Ser-45, MOD:00046." [PMID:11955436, PMID:16199882, PRO:IC]
Yes
organism-modification


PR:000036862
catenin beta-1 isoform 1 phosphorylated 5 (human)
hCTNNB1/iso:1/Phos:5
"A catenin beta-1 isoform 1 phosphorylated 5 in human. UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046." [PMID:16476742, PRO:IC]
Yes
organism-modification


PR:000036872
catenin beta-1 isoform 1 unphosphorylated 1 (human)
hCTNNB1/iso:1/UnPhos:1
"A catenin beta-1 isoform 1 unphosphorylated 1 in human. UniProtKB:P35222-1, Ser-552/Ser-675, PR:000026291." [PMID:16476742, PRO:KER]

organism-modification


PR:000037181
catenin beta-1 isoform 1 phosphorylated 6 (human)
hCTNNB1/iso:1/Phos:6
"A catenin beta-1 isoform 1 phosphorylated 6 in human. UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:19667122, PRO:IC]
Yes
organism-modification


PR:000037185
catenin beta-1 isoform 1 unphosphorylated 2 (human)
hCTNNB1/iso:1/UnPhos:2
"A catenin beta-1 isoform 1 unphosphorylated 2 in human. UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291." [PRO:CNA]
Yes
organism-modification


PR:000037190
catenin beta-1 isoform 1 phosphorylated 7 (human)
hCTNNB1/iso:1/Phos:7
"A catenin beta-1 isoform 1 phosphorylated 7 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:14500351, PRO:IC]
Yes
organism-modification


PR:000037192
catenin beta-1 isoform 1 phosphorylated 8 (human)
hCTNNB1/iso:1/Phos:8
"A catenin beta-1 isoform 1 phosphorylated 8 in human. UniProtKB:P35222-1, Tyr-333, MOD:00048." [PMID:22056988, PRO:IC]
Yes
organism-modification


PR:000037194
catenin beta-1 isoform 1 phosphorylated 9 (human)
hCTNNB1/iso:1/Phos:9
"A catenin beta-1 isoform 1 phosphorylated 9 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048." [PMID:10593980, PRO:IC]
Yes
organism-modification


PR:000037196
catenin beta-1 isoform 1 unphosphorylated 3 (human)
hCTNNB1/iso:1/UnPhos:3
"A catenin beta-1 isoform 1 unphosphorylated 3 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, PR:000026291." [PMID:10593980, PRO:DAN, PRO:IC]

organism-modification


PR:000037229
catenin beta-1 isoform 1 phosphorylated 10 (human)
hCTNNB1/iso:1/Phos:10
"A catenin beta-1 isoform 1 phosphorylated 10 in human. UniProtKB:P35222-1, Ser-191/Ser-246, MOD:00046." [PMID:17009320, PRO:IC]

organism-modification


PR:000037515
catenin beta-1 isoform 1 phosphorylated 11 (human)
hCTNNB1/iso:1/Phos:11
"A catenin beta-1 isoform 1 phosphorylated 11 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]
Yes
organism-modification


PR:000037772
catenin beta-1 isoform 1 unphosphorylated 4 (human)
hCTNNB1/iso:1/UnPhos:4
"A catenin beta-1 isoform 1 unphosphorylated 4 in human. UniProtKB:P35222-1, Ser-33/Ser-37, PR:000026291." [PMID:20307497, PRO:IC, PRO:KER]

organism-modification


PR:000037811
catenin beta-1 isoform 1 unphosphorylated 5 (human)
hCTNNB1/iso:1/UnPhos:5
"A catenin beta-1 isoform 1 unphosphorylated 5 in human. UniProtKB:P35222-1, Ser-33/Ser-37/Thr-41, PR:000026291." [PMID:19667122, PMID:20419129, PMID:21152425, PMID:23617586, PRO:KER]

organism-modification


PR:000037813
catenin beta-1 isoform 1 unphosphorylated 6 (human)
hCTNNB1/iso:1/UnPhos:6
"A catenin beta-1 isoform 1 unphosphorylated 6 in human. UniProtKB:P35222-1, Ser-45, PR:000026291." [PMID:20419129, PRO:KER]

organism-modification


PR:000044474
catenin beta-1 isoform 1 phosphorylated 12 (human)
hCTNNB1/iso:1/Phos:12
"A catenin beta-1 isoform 1 phosphorylated 12 in human. UniProtKB:P35222-1, Thr-393, MOD:00047." [PMID:12700239, PMID:19565571, PRO:KER]
Yes
organism-modification


PR:000044476
catenin beta-1 isoform 1 unphosphorylated 7 (human)
hCTNNB1/iso:1/UnPhos:7
"A catenin beta-1 isoform 1 unphosphorylated 7 in human. UniProtKB:P35222-1, Thr-393, PR:000026291." [PMID:12700239, PMID:19565571, PRO:KER]
Yes
organism-modification


PR:000044478
catenin beta-1 isoform 1 phosphorylated 13 (human)
hCTNNB1/iso:1/Phos:13
"A catenin beta-1 isoform 1 phosphorylated 13 in human. UniProtKB:P35222-1, Tyr-654, MOD:00048." [PMID:23640056, PRO:KER]
Yes
organism-modification


PR:000044510
catenin beta-1 isoform 1 phosphorylated 14 (human)
hCTNNB1/iso:1/Phos:14
"A catenin beta-1 isoform 1 (human) that has been phosphorylated on a Ser residue within the 14-3-3 recognition motif. UniProtKB:P35222-1, Ser-552, MOD:00046." [PMID:17287208, PRO:CNA]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000030192 hCTNNB1/iso:1/Phos:1
UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046		 acts_upstream_of_or_withinGO:0016055 Wnt signaling pathway PMID:22369945
enablesincreased GO:0003713 transcription coactivator activity relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945
PR:000035770 hCTNNB1/iso:1/Phos:2
UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)		 located_inGO:0005634 nucleus PMID:20026641
PR:000035772 hCTNNB1/iso:1/Phos:3
UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047		 enablesNOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:10074433
NOT GO:0005515 protein binding with PR:Q9UKB1 BTRCP2 PMID:10074433
PR:000035774 hCTNNB1/iso:1/Phos:4
UniProtKB:P35222-1, Ser-45, MOD:00046		 enablesincreased GO:0005515 protein binding with PR:P12830 CAM 120/80 (human) PMID:12051714; PMID:20419129; PMID:23606879
increased GO:0005515 protein binding with PR:P49841 GSK-3 beta (human) PMID:12051714; PMID:20419129; PMID:23606879
located_inGO:0005634 nucleus PMID:20419129
PR:000036862 hCTNNB1/iso:1/Phos:5
UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046		 enablesincreased GO:0003713 transcription coactivator activity relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
increased GO:0005515 protein binding relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
PR:000037181 hCTNNB1/iso:1/Phos:6
UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047		 located_indecreased GO:0005912 adherens junction relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:19667122
PR:000037185 hCTNNB1/iso:1/UnPhos:2
UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291		 enablesGO:0003713 transcription coactivator activity PMID:20419129
GO:0005515 protein binding PMID:20419129
located_inGO:0005634 nucleus PMID:20419129
PR:000037190 hCTNNB1/iso:1/Phos:7
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047		 acts_upstream_of_or_withindecreased GO:0007155 cell adhesion relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
GO:0010631 epithelial cell migration PMID:21152425
decreased GO:0034333 adherens junction assembly relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
enablesdecreased GO:0003713 transcription coactivator activity relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:20419129
NOT GO:0005515 protein binding with PR:Q9HCS4 HMG box transcription factor 3 (human) PMID:21152425
NOT GO:0005515 protein binding with PR:Q9NQB0 HMG box transcription factor 4 (human) PMID:21152425
NOT GO:0005515 protein binding with PR:Q9UJU2 hLEF1 PMID:21152425
NOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:21152425
NOT GO:0005515 protein binding with PR:P12830 CAM 120/80 (human) PMID:21152425
NOT GO:0005515 protein binding PMID:21152425
located_inGO:0005737 cytoplasm PMID:20419129
decreased GO:0005912 adherens junction relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
PR:000037192 hCTNNB1/iso:1/Phos:8
UniProtKB:P35222-1, Tyr-333, MOD:00048		 acts_upstream_of_or_withinGO:0007173 epidermal growth factor receptor signaling pathway PMID:22056988
enablesGO:0003713 transcription coactivator activity PMID:22056988
GO:0005515 protein binding PMID:22056988
located_inGO:0005634 nucleus PMID:22056988
PR:000037194 hCTNNB1/iso:1/Phos:9
UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048		 enablesincreased GO:0017025 TBP-class protein binding with PR:P20226 GTF2D1 PMID:11279024
decreased GO:0045296 cadherin binding relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 PMID:11279024
PR:000037515 hCTNNB1/iso:1/Phos:11
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046		 acts_upstream_of_or_withindecreased GO:0008283 cell population proliferation relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
decreased GO:0060070 canonical Wnt signaling pathway relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
enablesdecreased GO:0003713 transcription coactivator activity relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
increased GO:0005515 protein binding relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:16996060; PMID:21152425; PMID:23071615
PR:000044474 hCTNNB1/iso:1/Phos:12
UniProtKB:P35222-1, Thr-393, MOD:00047		 acts_upstream_of_or_withinGO:0016055 Wnt signaling pathway PMID:12700239
GO:0045944 positive regulation of transcription by RNA polymerase II PMID:12700239
enablesdecreased GO:0005515 protein binding with PR:Q9YGY0 axin PMID:19565571
PR:000044476 hCTNNB1/iso:1/UnPhos:7
UniProtKB:P35222-1, Thr-393, PR:000026291		 enablesGO:0005515 protein binding with PR:Q9YGY0 axin PMID:19565571
PR:000044478 hCTNNB1/iso:1/Phos:13
UniProtKB:P35222-1, Tyr-654, MOD:00048		 enablesGO:0003713 transcription coactivator activity PMID:23640056
PR:000044510 hCTNNB1/iso:1/Phos:14
UniProtKB:P35222-1, Ser-552, MOD:00046		 enablesGO:0071889 14-3-3 protein binding with PR:P63104 hYWHAZ PMID:17287208