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Protein Ontology report - tumor necrosis factor ligand superfamily member 6 (human)
PR:P48023 - http://purl.obolibrary.org/obo/PR_P48023
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P48023   
  PRO nametumor necrosis factor ligand superfamily member 6 (human) 
  Synonyms
PRO-Short-label: EXACT:hFASLG
Gene-based: RELATED:APT1LG1 | CD95L | FASL | FASLG | TNFSF6
Other: EXACT:apoptosis antigen ligand (human) | APTL (human) | CD178 (human) | CD95 ligand (human) | CD95-L (human) | Fas antigen ligand (human) | Fas ligand (human)
  Definition"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48023] 
  PRO Categoryorganism-gene 
  ParentPR:000000095 tumor necrosis factor ligand superfamily member 6
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11936 FASLG (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P48023
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P48023
tumor necrosis factor ligand superfamily member 6 (human)
hFASLG
"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48023]

organism-sequence


PR:P48023-1
tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA]
Yes
organism-sequence


PR:000036782
tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]
Yes
organism-modification


PR:000036458
tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036459
tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]
Yes
organism-sequence


PR:P48023-2
tumor necrosis factor ligand superfamily member 6 isoform h2 (human)
hFASLG/iso:h2
"A tumor necrosis factor ligand superfamily member 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-2." [PRO:DNx, UniProtKB:P48023]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036458 hFASLG/iso:FasL/NGlyco:1
UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160		 acts_upstream_of_or_withinGO:0097190 apoptotic signaling pathway PMID:9405425
enablesGO:0005102 signaling receptor binding PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble
UniProtKB:P48023-1, 130-281		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9396774
enablesGO:0005102 signaling receptor binding PMID:9405425
GO:0042802 identical protein binding PMID:7536672; PMID:9228058; PMID:9405425
located_inGO:0005615 extracellular space PMID:7536672
PR:000036782 hFASLG/iso:FasL/var:F273L
UniProtKB:P48023-1, Phe-275, CHEBI:30006		 enablesaltered GO:0005102 signaling receptor binding with PR:P25445 apo-1 antigen (human) PMID:9405425
GO:0042802 identical protein binding PMID:9405425
located_inGO:0009986 cell surface PMID:9405425
PR:P48023-1 hFASLG/iso:FasL acts_upstream_of_or_withinGO:0043123 positive regulation of canonical NF-kappaB signal transduction PMID:12761501