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Protein Ontology report - tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
PR:P48023-1 - http://purl.obolibrary.org/obo/PR_P48023-1
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P48023-1   
  PRO nametumor necrosis factor ligand superfamily member 6 isoform FasL (human) 
  Synonyms
PRO-Short-label: EXACT:hFASLG/iso:FasL
Other: EXACT:FASLG isoform 1 (human) | tumor necrosis factor ligand superfamily member 6 isoform 1 (human)
  Definition"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000000276 tumor necrosis factor ligand superfamily member 6 isoform FasL
PR:P48023 tumor necrosis factor ligand superfamily member 6 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P48023-1
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
Yes
organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036458 hFASLG/iso:FasL/NGlyco:1
UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160		 acts_upstream_of_or_withinGO:0097190 apoptotic signaling pathway PMID:9405425
enablesGO:0005102 signaling receptor binding PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble
UniProtKB:P48023-1, 130-281		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9396774
enablesGO:0005102 signaling receptor binding PMID:9405425
GO:0042802 identical protein binding PMID:7536672; PMID:9228058; PMID:9405425
located_inGO:0005615 extracellular space PMID:7536672
PR:000036782 hFASLG/iso:FasL/var:F273L
UniProtKB:P48023-1, Phe-275, CHEBI:30006		 enablesaltered GO:0005102 signaling receptor binding with PR:P25445 apo-1 antigen (human) PMID:9405425
GO:0042802 identical protein binding PMID:9405425
located_inGO:0009986 cell surface PMID:9405425
PR:P48023-1 hFASLG/iso:FasL acts_upstream_of_or_withinGO:0043123 positive regulation of canonical NF-kappaB signal transduction PMID:12761501