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Protein Ontology report - interleukin-1 receptor-associated kinase 1 (human)
PR:P51617 - http://purl.obolibrary.org/obo/PR_P51617
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P51617   
  PRO nameinterleukin-1 receptor-associated kinase 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hIRAK1
Gene-based: RELATED:IRAK | IRAK1
Other: EXACT:IRAK-1 (human)
  Definition"An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000001782 interleukin-1 receptor-associated kinase 1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6112 IRAK1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P51617
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P51617 interleukin-1 receptor-associated kinase 1 (human)
hIRAK1

organism-sequence


PR:P51617-1 interleukin-1 receptor-associated kinase 1 isoform 1 (human)
hIRAK1/iso:1
Yes
organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
hIRAK1/iso:1/Phos:3
Yes
organism-modification


PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
hIRAK1/iso:1/Phos:4
Yes
organism-modification


PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
hIRAK1/iso:1/pSerThr+

organism-sequence


PR:P51617-2 interleukin-1 receptor-associated kinase 1 isoform h2 (human)
hIRAK1/iso:h2

organism-sequence


PR:P51617-3 interleukin-1 receptor-associated kinase 1 isoform h3 (human)
hIRAK1/iso:h3

organism-sequence


PR:P51617-4 interleukin-1 receptor-associated kinase 1 isoform h4 (human)
hIRAK1/iso:h4

organism-modification


PR:000048042 interleukin-1 receptor-associated kinase 1 phosphorylated 5 (human)
hIRAK1/Phos:5

organism-modification


PR:000048043 interleukin-1 receptor-associated kinase 1 phosphorylated 1 (human)
hIRAK1/Phos:1

organism-modification


PR:000048044 interleukin-1 receptor-associated kinase 1 phosphorylated 3 (human)
hIRAK1/Phos:3

organism-modification


PR:000062298 interleukin-1 receptor-associated kinase 1 phosphorylated 2 (human)
hIRAK1/Phos:2

organism-modification


PR:000064197 interleukin-1 receptor-associated kinase 1 phosphoserine and phosphothreonine form (human)
hIRAK1/pSerThr+

organism-modification


PR:000064772 interleukin-1 receptor-associated kinase 1 phosphorylated and ubiquitinated 1 (human)
hIRAK1/PhosUbiq:1

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hIRAK1 forms found in complexes   

hIRAK1 Component
 Complexes
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027492 hIRAK1/iso:1/Phos:3
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
PR:000027493 hIRAK1/iso:1/Phos:4
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
NOT GO:0005515 protein binding PMID:14625308
PR:000027494 hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047		 enablesGO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
GO:0016301 kinase activity PMID:11960013
PR:P51617-1 hIRAK1/iso:1 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
GO:0005515 protein binding with PR:Q9Y4K3 E3 ubiquitin-protein ligase TRAF6 (human) PMID:14625308