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Protein Ontology report - D(2) dopamine receptor isoform 2 (mouse)
PR:P61168-2 - http://purl.obolibrary.org/obo/PR_P61168-2
 
    Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P61168-2   
  PRO nameD(2) dopamine receptor isoform 2 (mouse) 
  Synonyms
PRO-Short-label: EXACT:mDRD2/iso:2
Other: EXACT:D2B (mouse)
  Definition"A D(2) dopamine receptor isoform 2 that is encoded in the genome of mouse." [PMID:11069937, PMID:1991517, PRO:KRC] 
  CommentNote: PMID:1991517 shows cloning of longer cDNA for isoform 1 (aka D2A) and shows distribution of both isoform 1 and isoform 2 mRNAs within mouse tissues. PMID:11069937ZCOLNSPACEZ Use RT-PCR to detect two forms of D2 mRNA that differ by 87 base pairs, corresponding to the two alternatively spliced isoforms of D2 mRNAs. Also detect the D2L mRNA by Northern blot from muscle striatum. 
  PRO Categoryorganism-sequence 
  ParentPR:000037413 D(2) dopamine receptor isoform 2
PR:P61168 D(2) dopamine receptor (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P61168-2
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001975 response to amphetaminePR:P61168-2 mDRD2/iso:2 MGI_ref:3611062; PMID:12476322
GO:0014059 regulation of dopamine secretionPR:P61168-2 mDRD2/iso:2 MGI_ref:3655899; PMID:11943831
GO:0032228 regulation of synaptic transmission, GABAergicPR:P61168-2 mDRD2/iso:2 MGI_ref:3628700; PMID:15489038
GO:0042220 response to cocainePR:P61168-2 mDRD2/iso:2 MGI_ref:3655899; PMID:11943831
GO:0043278 response to morphinePR:P61168-2 mDRD2/iso:2 MGI_ref:3655899; PMID:11943831
GO:0051967 negative regulation of synaptic transmission, glutamatergicPR:P61168-2 mDRD2/iso:2 MGI_ref:3628700; PMID:15489038
GO:0060160 negative regulation of dopamine receptor signaling pathwayPR:P61168-2 mDRD2/iso:2 MGI_ref:2181304; PMID:11089973

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/GoPR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517
PR:P61168-2 mDRD2/iso:2 MGI_ref:892768; PMID:1991517