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Protein Ontology report - mothers against decapentaplegic homolog 3 (human)
PR:P84022 - http://purl.obolibrary.org/obo/PR_P84022
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P84022   
  PRO namemothers against decapentaplegic homolog 3 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD3
Gene-based: RELATED:MADH3 | SMAD3
Other: EXACT:hMAD-3 | JV15-2 (human) | MAD homolog 3 (human) | Mad3 (human) | mothers against DPP homolog 3 (human) | SMAD 3 (human) | SMAD family member 3 (human) | Smad3 (human)
  Definition"A smad3 that is encoded in the genome of human." [] 
  PRO Categoryorganism-gene 
  ParentPR:000000365 smad3
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6769 SMAD3 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 15                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P84022
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P84022

mothers against decapentaplegic homolog 3 (human)

hSMAD3


"A smad3 that is encoded in the genome of human." []


organism-sequence



PR:000062539

mothers against decapentaplegic homolog 3 sequence variant S425F (human)

hSMAD3/var:S425F


"A mothers against decapentaplegic homolog 3 (human) that has a Phe residue at the position equivalent to Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-425, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-8944158]


organism-sequence



PR:000063486

mothers against decapentaplegic homolog 3 sequence variant S425C (human)

hSMAD3/var:S425C


"A mothers against decapentaplegic homolog 3 (human) that has a Cys residue at the position equivalent to Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-425, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-3308499]


organism-sequence



PR:P84022-1

mothers against decapentaplegic homolog 3 isoform 1 (human)

hSMAD3/iso:1


"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026333

smad3 isoform 1 phosphorylated 1 (human)

hSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]

Yes

organism-modification



PR:000036557

smad3 isoform 1 acetylated and phosphorylated 1 (human)

hSMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

organism-sequence



PR:P84022-2

mothers against decapentaplegic homolog 3 isoform h2 (human)

hSMAD3/iso:h2


"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-2." [PRO:DNx, UniProtKB:P84022]


organism-sequence



PR:P84022-3

mothers against decapentaplegic homolog 3 isoform h3 (human)

hSMAD3/iso:h3


"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-3." [PRO:DNx, UniProtKB:P84022]


organism-sequence



PR:P84022-4

mothers against decapentaplegic homolog 3 isoform h4 (human)

hSMAD3/iso:h4


"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-4." [PRO:DNx, UniProtKB:P84022]


organism-modification



PR:000049285

mothers against decapentaplegic homolog 3 phosphorylated 1 (human)

hSMAD3/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has been post-translationally modified to include phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-171184, Reactome:R-HSA-177104]


organism-modification



PR:000049286

mothers against decapentaplegic homolog 3 phosphorylated 2 (human)

hSMAD3/Phos:2


"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-179, and phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2176471]


organism-modification



PR:000049287

mothers against decapentaplegic homolog 3 ubiquitinated form (human)

hSMAD3/UbiqLys+


"A mothers against decapentaplegic homolog 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:P84022, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782830]


organism-modification



PR:000064859

mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human)

hSMAD3/PhosUbiq:1


"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-179, Ser-423, and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1 and that includes at least one ubiquitinated lysine. Example: UniProtKB:P84022-1, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-9773841]


organism-modification



PR:000060563

mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human)

hSMAD3/var:R268H/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has a His residue at the position equivalent to Arg-268 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Arg-268, CHEBI:29979|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315080]


organism-modification



PR:000061858

mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human)

hSMAD3/ADPribPhos:1


"A mothers against decapentaplegic homolog 3 (human) that has been ADP-ribosylated on the residues at the positions equivalent to Glu-50 and Glu-52 and phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Glu-50/Glu-52, MOD:00300|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2187326]


organism-modification



PR:000063368

mothers against decapentaplegic homolog 3 phosphorylated 3 (human)

hSMAD3/Phos:3


"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-208 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-208, MOD:00046." [PRO:DNx, Reactome:R-HSA-9731114]


organism-modification



PR:000063580

mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human)

hSMAD3/var:R268C/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has a Cys residue at the position equivalent to Arg-268 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Arg-268, CHEBI:29950|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315075]


organism-modification



PR:000063639

mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human)

hSMAD3/var:D258N/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has an Asn residue at the position equivalent to Asp-258 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Asp-258, CHEBI:50347|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315470]


organism-modification



PR:000065228

mothers against decapentaplegic homolog 3 deaminated 1 (human)

hSMAD3/Deam:1


"A mothers against decapentaplegic homolog 3 (human) that has been deaminated on the residue at the position equivalent to Asn-24 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Asn-24, MOD:00684." [IEDB_epitope:1979961, PRO:DNx]


organism-modification



PR:000065534

mothers against decapentaplegic homolog 3 methylated 1 (human)

hSMAD3/Me:1


"A mothers against decapentaplegic homolog 3 (human) that has been methylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-121, MOD:00660." [IEDB_epitope:1004379, PRO:DNx]


organism-modification



PR:000073148

mothers against decapentaplegic homolog 3 cysteinylated 1 (human)

hSMAD3/Cyst:1


"A mothers against decapentaplegic homolog 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-121, MOD:00765." [IEDB_epitope:925064, PRO:DNx]


organism-modification



PR:000074741

mothers against decapentaplegic homolog 3 methylated 2 (human)

hSMAD3/Me:2


"A mothers against decapentaplegic homolog 3 (human) that has been methylated on the residue at the position equivalent to Cys-320 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-320, MOD:00660." [IEDB_epitope:1059096, PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006366 transcription by RNA polymerase IIPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000026333 hSMAD3/iso:1/Phos:1 PMID:8774881; PMID:9380693
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:P84022-1 hSMAD3/iso:1 PMID:8774881

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
GO:0003700 DNA-binding transcription factor activityPR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
GO:0005515 protein bindingPR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
GO:0008134 transcription factor bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15084259
GO:0046332 SMAD bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15350224; PMID:9311995

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005634 nucleusPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10846168; PMID:15280432
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
GO:0005667 transcription factor complexPR:000026333 hSMAD3/iso:1/Phos:1 PMID:12374795
GO:0005737 cytoplasmPR:P84022-1 hSMAD3/iso:1 PMID:17074053