Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - voltage-gated inwardly rectifying potassium channel KCNH2 (human)

PR:Q12809 - http://purl.obolibrary.org/obo/PR_Q12809

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:Q12809

PRO name

voltage-gated inwardly rectifying potassium channel KCNH2 (human)

Synonyms

PRO-Short-label:	EXACT:	hKCNH2
Gene-based:	RELATED:	ERG \| ERG1 \| HERG \| KCNH2
Other:	EXACT:	Eag homolog (human) \| Eag-related protein 1 (human) \| ERG-1 (human) \| ether-a-go-go-related gene potassium channel 1 (human) \| ether-a-go-go-related protein 1 (human) \| H-ERG \| hERG-1 \| hERG1 \| potassium voltage-gated channel subfamily H member 2 (human) \| voltage-gated potassium channel subunit Kv11.1 (human)

Definition

"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12809]

PRO Category

organism-gene

Parent

PR:000000791 voltage-gated inwardly rectifying potassium channel KCNH2
PR:000029067 Homo sapiens protein

Gene Template

HGNC:6251 KCNH2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	6
Modification	0	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	UniProtKB:Q12809

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

organism-gene

PR:Q12809 voltage-gated inwardly rectifying potassium channel KCNH2 (human)

hKCNH2

Yes

organism-sequence

PR:Q12809-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A

Yes

organism-modification

PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1

Yes

organism-modification

PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1

Yes

organism-modification

PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1

Yes

organism-modification

PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-

Yes

organism-sequence

PR:Q12809-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B

Yes

organism-sequence

PR:Q12809-4 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h4 (human)

hKCNH2/iso:h4

organism-sequence

PR:Q12809-5 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO

Yes

organism-sequence

PR:Q12809-6 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B-USO (human)

hKCNH2/iso:B-USO

organism-sequence

PR:Q12809-7 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h3.1 (human)

hKCNH2/iso:h3.1

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000036581 hKCNH2/iso:A/NGlyco:1 UniProtKB:Q12809-1, Asn-598, MOD:00160	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:12063277
	located_in	GO:0009986 cell surface	PMID:12063277
PR:000036583 hKCNH2/iso:A/Phos:1	enables	decreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod	PMID:10837251
PR:000036583 hKCNH2/iso:A/Phos:1	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1 UniProtKB:Q12809-1, Asn-598, PR:000026291	located_in	GO:0009986 cell surface	PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes-	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:10837251; PMID:9351446
PR:Q12809 hKCNH2	acts_upstream_of_or_within	GO:0006936 muscle contraction	PMID:7736582
PR:Q12809 hKCNH2	acts_upstream_of_or_within	GO:0008016 regulation of heart contraction	PMID:7736582
PR:Q12809-1 hKCNH2/iso:A	enables	GO:0030552 cAMP binding	PMID:10837251
PR:Q12809-2 hKCNH2/iso:B	enables	contributes_to GO:0005251 delayed rectifier potassium channel activity	PMID:9351446
PR:Q12809-5 hKCNH2/iso:A-USO	enables	altered\|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod	PMID:9765245
PR:Q12809-5 hKCNH2/iso:A-USO	located_in	GO:0008076 voltage-gated potassium channel complex	PMID:9765245