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Protein Ontology report - voltage-gated inwardly rectifying potassium channel KCNH2 (human)
PR:Q12809 - http://purl.obolibrary.org/obo/PR_Q12809
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q12809   
  PRO namevoltage-gated inwardly rectifying potassium channel KCNH2 (human) 
  Synonyms
PRO-Short-label: EXACT:hKCNH2
Gene-based: RELATED:ERG | ERG1 | HERG | KCNH2
Other: EXACT:Eag homolog (human) | Eag-related protein 1 (human) | ERG-1 (human) | ether-a-go-go-related gene potassium channel 1 (human) | ether-a-go-go-related protein 1 (human) | H-ERG | hERG-1 | hERG1 | potassium voltage-gated channel subfamily H member 2 (human) | voltage-gated potassium channel subunit Kv11.1 (human)
  Definition"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12809
  PRO Categoryorganism-gene 
  ParentPR:000000791 voltage-gated inwardly rectifying potassium channel KCNH2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6251 KCNH2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q12809
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q12809

voltage-gated inwardly rectifying potassium channel KCNH2 (human)

hKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

organism-sequence



PR:Q12809-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-4

voltage-gated inwardly rectifying potassium channel KCNH2 isoform h4 (human)

hKCNH2/iso:h4


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-4." [PRO:DNx, UniProtKB:Q12809]


organism-sequence



PR:Q12809-5

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-6

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B-USO (human)

hKCNH2/iso:B-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-6." [PRO:DNx, UniProtKB:Q12809]


organism-sequence



PR:Q12809-7

voltage-gated inwardly rectifying potassium channel KCNH2 isoform h3.1 (human)

hKCNH2/iso:h3.1


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-7." [PRO:DNx, UniProtKB:Q12809]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036581 hKCNH2/iso:A/NGlyco:1
UniProtKB:Q12809-1, Asn-598, MOD:00160
located_inGO:0008076 voltage-gated potassium channel complex PMID:12063277
GO:0009986 cell surface PMID:12063277
PR:000036583 hKCNH2/iso:A/Phos:1 enablesdecreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:10837251
located_inGO:0008076 voltage-gated potassium channel complex PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1
UniProtKB:Q12809-1, Asn-598, PR:000026291
located_inGO:0009986 cell surface PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes- enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10837251; PMID:9351446
PR:Q12809 hKCNH2 acts_upstream_of_or_withinGO:0006936 muscle contraction PMID:7736582
GO:0008016 regulation of heart contraction PMID:7736582
PR:Q12809-1 hKCNH2/iso:A enablesGO:0030552 cAMP binding PMID:10837251
PR:Q12809-2 hKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446
PR:Q12809-5 hKCNH2/iso:A-USO enablesaltered|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:9765245
located_inGO:0008076 voltage-gated potassium channel complex PMID:9765245