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Protein Ontology report - activin receptor type-2B (human)
PR:Q13705 - http://purl.obolibrary.org/obo/PR_Q13705
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13705   
  PRO nameactivin receptor type-2B (human) 
  Synonyms
PRO-Short-label: EXACT:hACVR2B
Gene-based: RELATED:ACVR2B
Other: EXACT:activin receptor type IIB (human) | ACTR-IIB (human)
  Definition"An activin receptor type-2B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13705] 
  PRO Categoryorganism-gene 
  ParentPR:000000071 activin receptor type-2B
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:174 ACVR2B (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13705
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q13705 activin receptor type-2B (human)
hACVR2B

organism-sequence


PR:000000214 activin receptor type-2B sequence variant R40H (human)
hACVR2B/var:R40H
Yes
organism-sequence


PR:000000215 activin receptor type-2B sequence variant V494I (human)
hACVR2B/var:V494I
Yes
organism-sequence


PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human)
hACVR2B/iso:ActR-IIB2
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human)
hACVR2B/iso:ActR-IIB1
Yes
organism-modification


PR:000046259 activin receptor type-2B, signal peptide removed form (human)
hACVR2B/SigPep-

organism-modification


PR:000076998 activin receptor type-2B phosphorylated 1 (human)
hACVR2B/Phos:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:Q13705-1 hACVR2B/iso:ActR-IIB2 PMID:8161782

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050545 visceral heterotaxyPR:000000214 hACVR2B/var:R40H PMID:9916847
PR:000000215 hACVR2B/var:V494I PMID:9916847

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004675 transmembrane receptor protein serine/threonine kinase activityPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8622651
GO:0005515 protein bindingPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:11279102; PMID:9872992
GO:0016362 activin receptor activity, type IIPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8622651
NOT GO:0016362 activin receptor activity, type IIPR:Q13705-2 hACVR2B/iso:ActR-IIB1 PMID:9916847

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8161782
GO:0048179 activin receptor complexPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8622651
SO:0001587 stop_gainedPR:Q13705-2 hACVR2B/iso:ActR-IIB1 PMID:9916847