Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - bone morphogenetic protein receptor type-2 (human)

PR:Q13873 - http://purl.obolibrary.org/obo/PR_Q13873

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:Q13873

PRO name

bone morphogenetic protein receptor type-2 (human)

Synonyms

PRO-Short-label:	EXACT:	hBMPR2
Gene-based:	RELATED:	BMPR2 \| PPH1
Other:	EXACT:	BMP type II receptor (human) \| BMP type-2 receptor (human) \| BMPR-2 (human) \| BMPR-II (human) \| bone morphogenetic protein receptor type II (human)

Definition

"A BMP receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13873]

PRO Category

organism-gene

Parent

PR:000000037 BMP receptor type-2
PR:000029067 Homo sapiens protein

Gene Template

HGNC:1078 BMPR2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	16
Modification	0	Organism-Modification	7

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	UniProtKB:Q13873

Back to top

Protein Forms

Switch to Compact View

Category

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?

organism-gene

PR:Q13873

bone morphogenetic protein receptor type-2 (human)

hBMPR2

"A BMP receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13873]

organism-sequence

PR:000000149

BMP receptor type-2 sequence variant C60Y (human)

hBMPR2/var:C60Y

"A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-60, CHEBI:46858." [PMID:11015450, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000150

BMP receptor type-2 sequence variant D485G (human)

hBMPR2/var:D485G

"A bone morphogenetic protein receptor type-2 (human) that has a Gly residue at the position equivalent to Asp-485 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asp-485, CHEBI:29947." [PMID:10973254, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000151

BMP receptor type-2 sequence variant R491Q (human)

hBMPR2/var:R491Q

"A bone morphogenetic protein receptor type-2 (human) that has a Gln residue at the position equivalent to Arg-491 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Arg-491, CHEBI:30011." [PMID:10903931, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000152

BMP receptor type-2 sequence variant R491W (human)

hBMPR2/var:R491W

"A bone morphogenetic protein receptor type-2 (human) that has a Trp residue at the position equivalent to Arg-491 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Arg-491, CHEBI:29954." [PMID:10903931, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000153

BMP receptor type-2 sequence variant K512T (human)

hBMPR2/var:K512T

"A bone morphogenetic protein receptor type-2 (human) that has a Thr residue at the position equivalent to Lys-512 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Lys-512, CHEBI:30013." [PMID:11115378, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000154

BMP receptor type-2 sequence variant N519K (human)

hBMPR2/var:N519K

"A bone morphogenetic protein receptor type-2 (human) that has a Lys residue at the position equivalent to Asn-519 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asn-519, CHEBI:29967." [PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000155

BMP receptor type-2 sequence variant C117Y (human)

hBMPR2/var:C117Y

"A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-117 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-117, CHEBI:46858." [PMID:11015450, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000156

BMP receptor type-2 sequence variant C118W (human)

hBMPR2/var:C118W

"A bone morphogenetic protein receptor type-2 (human) that has a Trp residue at the position equivalent to Cys-118 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-118, CHEBI:29954." [PMID:10973254, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000157

BMP receptor type-2 sequence variant C123R (human)

hBMPR2/var:C123R

"A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29952." [PMID:11115378, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000158

BMP receptor type-2 sequence variant C123S (human)

hBMPR2/var:C123S

"A bone morphogenetic protein receptor type-2 (human) that has a Ser residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29999." [PMID:11115378, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000159

BMP receptor type-2 sequence variant E224D (human)

hBMPR2/var:E224D

"A bone morphogenetic protein receptor type-2 (human) that has an Asp residue at the position equivalent to Glu-224 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Glu-224, CHEBI:29958." [PMID:11115378, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000160

BMP receptor type-2 sequence variant C347Y (human)

hBMPR2/var:C347Y

"A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-347 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-347, CHEBI:46858." [PMID:10973254, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000161

BMP receptor type-2 sequence variant C420R (human)

hBMPR2/var:C420R

"A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-420 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-420, CHEBI:29952." [PMID:11115378, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:000000162

BMP receptor type-2 sequence variant C483R (human)

hBMPR2/var:C483R

"A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-483 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-483, CHEBI:29952." [PMID:11015450, PMID:12358323, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:Q13873-1

bone morphogenetic protein receptor type-2 isoform 1 (human)

hBMPR2/iso:1

"A BMP receptor type-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence

PR:Q13873-2

bone morphogenetic protein receptor type-2 isoform h2 (human)

hBMPR2/iso:h2

"A bone morphogenetic protein receptor type-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13873-2." [PRO:DNx, UniProtKB:Q13873]

organism-modification

PR:000046497

bone morphogenetic protein receptor type-2, signal peptide removed form (human)

hBMPR2/SigPep-

"A bone morphogenetic protein receptor type-2 (human) that has had the signal peptide removed. UniProtKB:Q13873, 27-1038." [PRO:DNx, Reactome:R-HSA-201442]

organism-modification

PR:000057061

bone morphogenetic protein receptor type-2 N-glycosylated 1 (human)

hBMPR2/NGlyco:1

"A bone morphogenetic protein receptor type-2 (human) that has been N-glycosylated at the residue equivalent to Asn-827 of the amino acid sequence represented by UniProtKB:Q13873-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:Q13873-1, Asn-827, MOD:00160~GNO:G10486CT." [GlyGen:Q13873-1, PMID:29671580, PRO:DNx]

organism-modification

PR:000057062

bone morphogenetic protein receptor type-2 O-glycosylated 1 (human)

hBMPR2/OGlyco:1

"A bone morphogenetic protein receptor type-2 (human) that has been O-glycosylated at the residue equivalent to Thr-137 of the amino acid sequence represented by UniProtKB:Q13873-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q13873-1, Thr-137, MOD:00005~GNO:G43417UB." [GlyGen:Q13873-1, PMID:30459171, PRO:DNx]

organism-modification

PR:000065377

bone morphogenetic protein receptor type-2 methylated 1 (human)

hBMPR2/Me:1

"A bone morphogenetic protein receptor type-2 (human) that has been methylated on the residue at the position equivalent to Cys-910 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-910, MOD:00660." [IEDB_epitope:1035856, PRO:DNx]

organism-modification

PR:000065967

bone morphogenetic protein receptor type-2 deaminated 1 (human)

hBMPR2/Deam:1

"A bone morphogenetic protein receptor type-2 (human) that has been deaminated on the residue at the position equivalent to Asn-728 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asn-728, MOD:00684." [IEDB_epitope:1583797, PRO:DNx]

organism-modification

PR:000073289

bone morphogenetic protein receptor type-2 deaminated 2 (human)

hBMPR2/Deam:2

"A bone morphogenetic protein receptor type-2 (human) that has been deaminated on the residue at the position equivalent to Asn-861 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asn-861, MOD:00684." [IEDB_epitope:1738174, PRO:DNx]

organism-modification

PR:000081621

bone morphogenetic protein receptor type-2 deaminated 3 (human)

hBMPR2/Deam:3

"A bone morphogenetic protein receptor type-2 (human) that has been deaminated on the residue at the position equivalent to Asn-827 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asn-827, MOD:00684." [IEDB_epitope:1591068, PRO:DNx]

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000149 hBMPR2/var:C60Y Example: UniProtKB:Q13873-1, Cys-60, CHEBI:46858	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11015450
PR:000000150 hBMPR2/var:D485G Example: UniProtKB:Q13873-1, Asp-485, CHEBI:29947	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:10973254
PR:000000151 hBMPR2/var:R491Q Example: UniProtKB:Q13873-1, Arg-491, CHEBI:30011	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:10903931
PR:000000152 hBMPR2/var:R491W Example: UniProtKB:Q13873-1, Arg-491, CHEBI:29954	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:10903931
PR:000000153 hBMPR2/var:K512T Example: UniProtKB:Q13873-1, Lys-512, CHEBI:30013	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11115378
PR:000000154 hBMPR2/var:N519K Example: UniProtKB:Q13873-1, Asn-519, CHEBI:29967	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	UniProtKB_VAR:VAR_013683
PR:000000155 hBMPR2/var:C117Y Example: UniProtKB:Q13873-1, Cys-117, CHEBI:46858	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11015450
PR:000000156 hBMPR2/var:C118W Example: UniProtKB:Q13873-1, Cys-118, CHEBI:29954	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:10973254
PR:000000157 hBMPR2/var:C123R Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29952	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11115378
PR:000000158 hBMPR2/var:C123S Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29999	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11115378
PR:000000159 hBMPR2/var:E224D Example: UniProtKB:Q13873-1, Glu-224, CHEBI:29958	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11115378
PR:000000160 hBMPR2/var:C347Y Example: UniProtKB:Q13873-1, Cys-347, CHEBI:46858	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:10973254
PR:000000161 hBMPR2/var:C420R Example: UniProtKB:Q13873-1, Cys-420, CHEBI:29952	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11115378
PR:000000162 hBMPR2/var:C483R Example: UniProtKB:Q13873-1, Cys-483, CHEBI:29952	associated_with_disease_progression	DO:14557 primary pulmonary hypertension	PMID:11015450; PMID:12358323
PR:Q13873-1 hBMPR2/iso:1	acts_upstream_of_or_within	GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway	PMID:7644468
	enables	GO:0005515 protein binding with PR:P12643 BMP-2 (human)	PMID:7791754
	enables	GO:0005515 protein binding with PR:P18075 BMP-7 (human)	PMID:7791754
	located_in	GO:0005886 plasma membrane	PMID:7791754
		GO:0009986 cell surface	PMID:10712517
		GO:0043235 receptor complex	PMID:7791754