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Protein Ontology report - bone morphogenetic protein receptor type-2 (human)
PR:Q13873 - http://purl.obolibrary.org/obo/PR_Q13873
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13873   
  PRO namebone morphogenetic protein receptor type-2 (human) 
  Synonyms
PRO-Short-label: EXACT:hBMPR2
Gene-based: RELATED:BMPR2 | PPH1
Other: EXACT:BMP type II receptor (human) | BMP type-2 receptor (human) | BMPR-2 (human) | BMPR-II (human) | bone morphogenetic protein receptor type II (human)
  Definition"A BMP receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13873] 
  PRO Categoryorganism-gene 
  ParentPR:000000037 BMP receptor type-2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1078 BMPR2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 16                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13873
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q13873 bone morphogenetic protein receptor type-2 (human)
hBMPR2

organism-sequence


PR:000000149 BMP receptor type-2 sequence variant C60Y (human)
hBMPR2/var:C60Y
Yes
organism-sequence


PR:000000150 BMP receptor type-2 sequence variant D485G (human)
hBMPR2/var:D485G
Yes
organism-sequence


PR:000000151 BMP receptor type-2 sequence variant R491Q (human)
hBMPR2/var:R491Q
Yes
organism-sequence


PR:000000152 BMP receptor type-2 sequence variant R491W (human)
hBMPR2/var:R491W
Yes
organism-sequence


PR:000000153 BMP receptor type-2 sequence variant K512T (human)
hBMPR2/var:K512T
Yes
organism-sequence


PR:000000154 BMP receptor type-2 sequence variant N519K (human)
hBMPR2/var:N519K
Yes
organism-sequence


PR:000000155 BMP receptor type-2 sequence variant C117Y (human)
hBMPR2/var:C117Y
Yes
organism-sequence


PR:000000156 BMP receptor type-2 sequence variant C118W (human)
hBMPR2/var:C118W
Yes
organism-sequence


PR:000000157 BMP receptor type-2 sequence variant C123R (human)
hBMPR2/var:C123R
Yes
organism-sequence


PR:000000158 BMP receptor type-2 sequence variant C123S (human)
hBMPR2/var:C123S
Yes
organism-sequence


PR:000000159 BMP receptor type-2 sequence variant E224D (human)
hBMPR2/var:E224D
Yes
organism-sequence


PR:000000160 BMP receptor type-2 sequence variant C347Y (human)
hBMPR2/var:C347Y
Yes
organism-sequence


PR:000000161 BMP receptor type-2 sequence variant C420R (human)
hBMPR2/var:C420R
Yes
organism-sequence


PR:000000162 BMP receptor type-2 sequence variant C483R (human)
hBMPR2/var:C483R
Yes
organism-sequence


PR:Q13873-1 bone morphogenetic protein receptor type-2 isoform 1 (human)
hBMPR2/iso:1
Yes
organism-sequence


PR:Q13873-2 bone morphogenetic protein receptor type-2 isoform h2 (human)
hBMPR2/iso:h2

organism-modification


PR:000046497 bone morphogenetic protein receptor type-2, signal peptide removed form (human)
hBMPR2/SigPep-

organism-modification


PR:000057061 bone morphogenetic protein receptor type-2 N-glycosylated 1 (human)
hBMPR2/NGlyco:1

organism-modification


PR:000057062 bone morphogenetic protein receptor type-2 O-glycosylated 1 (human)
hBMPR2/OGlyco:1

organism-modification


PR:000065377 bone morphogenetic protein receptor type-2 methylated 1 (human)
hBMPR2/Me:1

organism-modification


PR:000065967 bone morphogenetic protein receptor type-2 deaminated 1 (human)
hBMPR2/Deam:1

organism-modification


PR:000073289 bone morphogenetic protein receptor type-2 deaminated 2 (human)
hBMPR2/Deam:2

organism-modification


PR:000081621 bone morphogenetic protein receptor type-2 deaminated 3 (human)
hBMPR2/Deam:3

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:Q13873-1 hBMPR2/iso:1 PMID:7644468

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:14557 primary pulmonary hypertensionPR:000000149 hBMPR2/var:C60Y PMID:11015450
PR:000000150 hBMPR2/var:D485G PMID:10973254
PR:000000151 hBMPR2/var:R491Q PMID:10903931
PR:000000152 hBMPR2/var:R491W PMID:10903931
PR:000000153 hBMPR2/var:K512T PMID:11115378
PR:000000154 hBMPR2/var:N519K UniProtKB_VAR:VAR_013683
PR:000000155 hBMPR2/var:C117Y PMID:11015450
PR:000000156 hBMPR2/var:C118W PMID:10973254
PR:000000157 hBMPR2/var:C123R PMID:11115378
PR:000000158 hBMPR2/var:C123S PMID:11115378
PR:000000159 hBMPR2/var:E224D PMID:11115378
PR:000000160 hBMPR2/var:C347Y PMID:10973254
PR:000000161 hBMPR2/var:C420R PMID:11115378
PR:000000162 hBMPR2/var:C483R PMID:11015450; PMID:12358323

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515 protein bindingPR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754
PR:Q13873-1 hBMPR2/iso:1 PMID:7791754

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:Q13873-1 hBMPR2/iso:1 PMID:7791754
GO:0009986 cell surfacePR:Q13873-1 hBMPR2/iso:1 PMID:10712517
GO:0043235 receptor complexPR:Q13873-1 hBMPR2/iso:1 PMID:7791754