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Protein Ontology report - mothers against decapentaplegic homolog 2 (human)
PR:Q15796 - http://purl.obolibrary.org/obo/PR_Q15796
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q15796   
  PRO namemothers against decapentaplegic homolog 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD2
Gene-based: RELATED:MADH2 | MADR2 | SMAD2
Other: EXACT:hMAD-2 | JV18-1 (human) | MAD homolog 2 (human) | Mad-related protein 2 (human) | mothers against DPP homolog 2 (human) | SMAD 2 (human) | SMAD family member 2 (human) | Smad2 (human)
  Definition"A smad2 that is encoded in the genome of human." [] 
  PRO Categoryorganism-gene 
  ParentPR:000000364 smad2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6768 SMAD2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 28                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q15796
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q15796 mothers against decapentaplegic homolog 2 (human)
hSMAD2

organism-sequence


PR:000000470 smad2 sequence variant R133C (human)
hSMAD2/var:R133C
Yes
organism-sequence


PR:000000471 smad2 sequence variant L440R (human)
hSMAD2/var:L440R
Yes
organism-sequence


PR:000000472 smad2 sequence variant P445H (human)
hSMAD2/var:P445H
Yes
organism-sequence


PR:000000473 smad2 sequence variant D450E (human)
hSMAD2/var:D450E
Yes
organism-sequence


PR:000000474 smad2 sequence variant 5 (human)
hSMAD2/var:5
Yes
organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000025960 smad2 isoform unphosphorylated 1 (human)
hSMAD2/iso:[Long/Short]/UnPhos:1

organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1

organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300A/InitMet-/Phos:1

organism-modification


PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human)
hSMAD2/var:S464L/InitMet-

organism-modification


PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300V/InitMet-/Phos:1

organism-modification


PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300N/InitMet-/Phos:1

organism-modification


PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:A354T/InitMet-/Phos:1

organism-modification


PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305Q/InitMet-/Phos:1

organism-modification


PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human)
hSMAD2/InitMet-/Phos:2

organism-modification


PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human)
hSMAD2/var:S464*/InitMet-

organism-modification


PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human)
hSMAD2/var:S467P/InitMet-

organism-modification


PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305L/InitMet-/Phos:1

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000050145 smad2 phosphorylated 1 (human)
hSMAD2/Phos:1

organism-modification


PR:000065797 mothers against decapentaplegic homolog 2 methylated 1 (human)
hSMAD2/Me:1

organism-modification


PR:000077056 mothers against decapentaplegic homolog 2 cysteinylated 1 (human)
hSMAD2/Cyst:1

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hSMAD2 forms found in complexes   

hSMAD2 Component
 Complexes
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:15690394; PMID:9689110
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0007165 signal transductionPR:000000470 hSMAD2/var:R133C PMID:8752209
PR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228
PR:000025938 hSMAD2/iso:Short/Phos:1 PMID:9873005
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:8752209
GO:0060395 SMAD protein signal transductionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:5672 large intestine cancerPR:000000470 hSMAD2/var:R133C PMID:8752209
PR:000000471 hSMAD2/var:L440R PMID:8752209
PR:000000472 hSMAD2/var:P445H PMID:8752209
PR:000000473 hSMAD2/var:D450E PMID:8752209
PR:000000474 hSMAD2/var:5 PMID:8673135

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8980228; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
GO:0003677 DNA bindingPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:14701940; PMID:9873005
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
GO:0003700 DNA-binding transcription factor activityPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:9873005
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
GO:0003712 transcription coregulator activityPR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025938 hSMAD2/iso:Short/Phos:1 PMID:14701940; PMID:9873005
GO:0003713 transcription coactivator activityPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9689110
NOT GO:0003713 transcription coactivator activityPR:000000470 hSMAD2/var:R133C PMID:8752209
PR:000000472 hSMAD2/var:P445H PMID:8752209
PR:000000473 hSMAD2/var:D450E PMID:8752209
PR:000000474 hSMAD2/var:5 PMID:8673135
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4 PMID:10197981
GO:0005515 protein bindingPR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:8980228
GO:0046332 SMAD bindingPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9311995
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595; PMID:17074053
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0005737 cytoplasmPR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4 PMID:10197981
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:15280432; PMID:17074053
GO:0005769 early endosomePR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:12356868