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Protein Ontology report - endonuclease 8-like 2 (human)
PR:Q969S2 - http://purl.obolibrary.org/obo/PR_Q969S2
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q969S2   
  PRO nameendonuclease 8-like 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hNEIL2
Gene-based: RELATED:NEIL2
Other: EXACT:DNA glycosylase/AP lyase Neil2 (human) | DNA-(apurinic or apyrimidinic site) lyase Neil2 (human) | endonuclease VIII-like 2 (human) | NEH2 (human) | Nei homolog 2 (human) | Nei-like protein 2 (human)
  Definition"An endonuclease 8-like 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q969S2] 
  PRO Categoryorganism-gene 
  ParentPR:000011123 endonuclease 8-like 2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:18956 NEIL2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q969S2
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q969S2
endonuclease 8-like 2 (human)
hNEIL2
"An endonuclease 8-like 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q969S2]

organism-sequence


PR:Q969S2-1
endonuclease 8-like 2 isoform 1 (human)
hNEIL2/iso:1
"An endonuclease 8-like 2 isoform 1 that is encoded in the genome of human." [PRO:PD]

organism-modification


PR:000028592
endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)
hNEIL2/iso:1/InitMet-/Ac:1
"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]
Yes
organism-modification


PR:000045372
endonuclease 8-like 2 isoform 1 unacetylated 1 (human)
hNEIL2/iso:1/UnAc:1
"An endonuclease 8-like 2 isoform 1 (human) that lacks acetylation on Lys-50 and Lys-154. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291." [PMID:15175427, PRO:CNA]
Yes
organism-sequence


PR:Q969S2-2
endonuclease 8-like 2 isoform h2 (human)
hNEIL2/iso:h2
"An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-2." [PRO:DNx, UniProtKB:Q969S2]

organism-sequence


PR:Q969S2-3
endonuclease 8-like 2 isoform h3 (human)
hNEIL2/iso:h3
"An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-3." [PRO:DNx, UniProtKB:Q969S2]

organism-sequence


PR:Q969S2-4
endonuclease 8-like 2 isoform h4 (human)
hNEIL2/iso:h4
"An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-4." [PRO:DNx, UniProtKB:Q969S2]

organism-modification


PR:000048574
endonuclease 8-like 2, initiator methionine removed form (human)
hNEIL2/InitMet-
"An endonuclease 8-like 2 (human) that has had the initiator methionine removed. UniProtKB:Q969S2, 2-332." [PRO:DNx, Reactome:R-HSA-5649650]

organism-modification


PR:000028592
endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)
hNEIL2/iso:1/InitMet-/Ac:1
"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000028592 hNEIL2/iso:1/InitMet-/Ac:1
UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064		 enablesdecreased GO:0019104 DNA N-glycosylase activity relative to PR:000045372 endonuclease 8-like 2 isoform 1 unmodified form (human) PMID:15175427
PR:000045372 hNEIL2/iso:1/UnAc:1
UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291		 enablesGO:0019104 DNA N-glycosylase activity PMID:15175427