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Protein Ontology report - serine/threonine-protein kinase TBK1 (human)
PR:Q9UHD2 - http://purl.obolibrary.org/obo/PR_Q9UHD2
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q9UHD2   
  PRO nameserine/threonine-protein kinase TBK1 (human) 
  Synonyms
PRO-Short-label: EXACT:hTBK1
Gene-based: RELATED:NAK | TBK1
Other: EXACT:NF-kappa-B-activating kinase (human) | T2K (human) | TANK-binding kinase 1 (human)
  Definition"A serine/threonine-protein kinase TBK1 that is encoded in the genome of human." [PMID:17327220, PRO:CNA, Reactome:R-HSA-166267
  PRO Categoryorganism-gene 
  ParentPR:000001779 serine/threonine-protein kinase TBK1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11584 TBK1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9UHD2
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q9UHD2

serine/threonine-protein kinase TBK1 (human)

hTBK1


"A serine/threonine-protein kinase TBK1 that is encoded in the genome of human." [PMID:17327220, PRO:CNA, Reactome:R-HSA-166267]


organism-sequence



PR:Q9UHD2-1

serine/threonine-protein kinase TBK1 isoform 1 (human)

hTBK1/iso:1


"A serine/threonine-protein kinase TBK1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028695

serine/threonine-protein kinase TBK1 phosphorylated 1 (human)

hTBK1/Phos:1


"A serine/threonine-protein kinase TBK1 phosphorylated 1 in human. UniProtKB:Q9UHD2, Ser-172, MOD:00046." [PRO:CNA]


Yes
organism-modification



PR:000045519

serine/threonine-protein kinase TBK1 phosphorylated 2 (human)

hTBK1/Phos:2


"A serine/threonine-protein kinase TBK1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-527 in UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Ser-527, MOD:00046." [PMID:26407194, PRO:CNA]


organism-modification



PR:000064841

serine/threonine-protein kinase TBK1 phosphorylated and ubiquitinated 1 (human)

hTBK1/PhosUbiq:1


"A serine/threonine-protein kinase TBK1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-172 and ubiquitinated on the residue at the position equivalent to Lys-670 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Ser-172, MOD:00046|Lys-670, MOD:01148." [PRO:DNx, Reactome:R-HSA-3249397]


organism-modification



PR:000066943

serine/threonine-protein kinase TBK1 methylated 1 (human)

hTBK1/Me:1


"A serine/threonine-protein kinase TBK1 (human) that has been methylated on the residue at the position equivalent to Cys-605 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Cys-605, MOD:00660." [IEDB_epitope:1013457, PRO:DNx]


organism-modification



PR:000068123

serine/threonine-protein kinase TBK1 deaminated 1 (human)

hTBK1/Deam:1


"A serine/threonine-protein kinase TBK1 (human) that has been deaminated on the residue at the position equivalent to Asn-330 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Asn-330, MOD:00684." [IEDB_epitope:635471, PRO:DNx]


organism-modification



PR:000070007

serine/threonine-protein kinase TBK1 cysteinylated 1 (human)

hTBK1/Cyst:1


"A serine/threonine-protein kinase TBK1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-605 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Cys-605, MOD:00765." [IEDB_epitope:878347, PRO:DNx]


organism-modification



PR:000075441

serine/threonine-protein kinase TBK1 deaminated 2 (human)

hTBK1/Deam:2


"A serine/threonine-protein kinase TBK1 (human) that has been deaminated on the residue at the position equivalent to Asn-66 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Asn-66, MOD:00684." [IEDB_epitope:1800864, PRO:DNx]


organism-modification



PR:000077131

serine/threonine-protein kinase TBK1 deaminated 3 (human)

hTBK1/Deam:3


"A serine/threonine-protein kinase TBK1 (human) that has been deaminated on the residue at the position equivalent to Asn-557 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Asn-557, MOD:00684." [IEDB_epitope:1984490, PRO:DNx]


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hTBK1 forms found in complexes   

hTBK1 Component
Complexes
PR:000028695 hTBK1/Phos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)