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Protein Ontology report - TNF receptor-associated factor 6 (human)
PR:Q9Y4K3 - http://purl.obolibrary.org/obo/PR_Q9Y4K3
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q9Y4K3   
  PRO nameTNF receptor-associated factor 6 (human) 
  Synonyms
PRO-Short-label: EXACT:hTRAF6
Gene-based: RELATED:RNF85 | TRAF6
Other: EXACT:E3 ubiquitin-protein ligase TRAF6 (human) | interleukin-1 signal transducer (human) | RING finger protein 85 (human) | RING-type E3 ubiquitin transferase TRAF6 (human)
  Definition"A TNF receptor-associated factor 6 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9Y4K3] 
  PRO Categoryorganism-gene 
  ParentPR:000002292 TNF receptor-associated factor 6
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:12036 TRAF6 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9Y4K3
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q9Y4K3
TNF receptor-associated factor 6 (human)
hTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9Y4K3]

Yes
organism-sequence


PR:Q9Y4K3-1
TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000035714
TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
Yes
Yes
organism-modification


PR:000064696
TNF receptor-associated factor 6 ubiquitinated form (human)
hTRAF6/UbiqLys+
"A TNF receptor-associated factor 6 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q9Y4K3, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782845, Reactome:R-HSA-6783233]

organism-modification


PR:000066371
TNF receptor-associated factor 6 cysteinylated 1 (human)
hTRAF6/Cyst:1
"A TNF receptor-associated factor 6 (human) that has been cysteinylated on the residue at the position equivalent to Cys-390 of the amino acid sequence represented by UniProtKB:Q9Y4K3. UniProtKB:Q9Y4K3, Cys-390, MOD:00765." [IEDB_epitope:1004109, PRO:DNx]

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hTRAF6 forms found in complexes   

hTRAF6 Component
 Complexes
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:Ticam1:Ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:Ticam1:Ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:Ticam1:Ticam2:activated TLR4 complex (human)
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:Ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:Ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:Ticam1:activated TLR3 complex (human)
PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:Ticam1:Ticam2:activated TLR4 complex (human)
PR:000037344 traf6:Ticam1:activated TLR3 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035714 hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894