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Protein Ontology report - interleukin-1 receptor-associated kinase 3 (human)
PR:Q9Y616 - http://purl.obolibrary.org/obo/PR_Q9Y616
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q9Y616   
  PRO nameinterleukin-1 receptor-associated kinase 3 (human) 
  Synonyms
PRO-Short-label: EXACT:hIRAK3
Gene-based: RELATED:IRAK3
Other: EXACT:IL-1 receptor-associated kinase M (human) | inactive IL-1 receptor-associated kinase 3 (human) | IRAK-3 (human) | IRAK-M (human)
  Definition"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y616
  PRO Categoryorganism-gene 
  ParentPR:000001784 interleukin-1 receptor-associated kinase 3
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:17020 IRAK3 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9Y616
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q9Y616

interleukin-1 receptor-associated kinase 3 (human)

hIRAK3


"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y616]


organism-sequence



PR:Q9Y616-1

interleukin-1 receptor-associated kinase 3 isoform 1 (human)

hIRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 isoform 1 that is encoded in the genome of human." [GenBank:AF113136, PMID:10383454, PRO:CNA]

Yes

organism-sequence



PR:Q9Y616-2

interleukin-1 receptor-associated kinase 3 isoform h2 (human)

hIRAK3/iso:h2


"An interleukin-1 receptor-associated kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y616-2." [PRO:DNx, UniProtKB:Q9Y616]


organism-modification



PR:000073219

interleukin-1 receptor-associated kinase 3 phosphorylated 1 (human)

hIRAK3/Phos:1


"An interleukin-1 receptor-associated kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-335 of the amino acid sequence represented by UniProtKB:Q9Y616-1. Example: UniProtKB:Q9Y616-1, Ser-335, MOD:00046." [IEDB_epitope:912152, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9Y616-1 hIRAK3/iso:1 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454