Definition | "A death-inducing signaling complex in human that is composed of one molecule of caspase-8, three molecules of TNF receptor-associated factor 2, initiator methionine removed form, two molecules of FAS-associated death domain protein, one molecule of receptor-interacting serine/threonine-protein kinase 1, and three molecules of tumor necrosis factor receptor type 1-associated DEATH domain protein." [PRO:DAN, PRO:PDE, Reactome:R-HSA-140976] |